Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

Histone Acetylation Facilitates Rapid and Robust Memory CD8 T Cell Response through Differential Expression of Effector Molecules (Eomesodermin and Its Targets: Perforin and Granzyme B)

(2014) Y. Araki et al.   JOURNAL OF IMMUNOLOGY

Cell Death Mechanisms Induced by Cytotoxic Lymphocytes

(2010) L Chávez-Galán et al.   Cellular & Molecular Immunology

Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation

(2010) Kirsten M.L. Hertoghs et al.   JOURNAL OF CLINICAL INVESTIGATION

Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control

(2010) Adam R. Hersperger et al.   PLoS Pathogens

Perforin and IL-2 Upregulation Define Qualitative Differences among Highly Functional Virus-Specific Human CD8+ T Cells

(2010) George Makedonas et al.   PLoS Pathogens

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

(2009) Fernando Cruz-Guilloty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid Up-Regulation and Granule-Independent Transport of Perforin to the Immunological Synapse Define a Novel Mechanism of Antigen-Specific CD8+ T Cell Cytotoxic Activity

(2009) G. Makedonas et al.   JOURNAL OF IMMUNOLOGY

Distinct Profiles of Cytotoxic Granules in Memory CD8 T Cells Correlate with Function, Differentiation Stage, and Antigen Exposure

(2009) A. Harari et al.   JOURNAL OF VIROLOGY

Role of Natural Killer Cells in a Cohort of Elite Suppressors: Low Frequency of the Protective KIR3DS1 Allele and Limited Inhibition of Human Immunodeficiency Virus Type 1 Replication In Vitro

(2009) K. A. O'Connell et al.   JOURNAL OF VIROLOGY

Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes

(2009) H. Chen et al.   JOURNAL OF VIROLOGY

Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy

(2009) S. A. Migueles et al.   JOURNAL OF VIROLOGY

The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation

(2009) Julián Pardo et al.   MICROBES AND INFECTION

Biology and clinical relevance of granulysin

(2009) A. M. Krensky et al.   TISSUE ANTIGENS

Elucidating the elite: mechanisms of control in HIV-1 infection

(2009) Karen A. O’Connell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

Flow cytometric detection of perforin upregulation in human CD8 T cells

(2008) Adam R. Hersperger et al.   CYTOMETRY PART A

Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control

(2008) Stephen A. Migueles et al.   IMMUNITY

The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression

(2008) P. K. Chattopadhyay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HLA Class I-Restricted T-Cell Responses May Contribute to the Control of Human Immunodeficiency Virus Infection, but Such Responses Are Not Always Necessary for Long-Term Virus Control

(2008) B. Emu et al.   JOURNAL OF VIROLOGY