Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca2+-dependent NF-κB and MAPK pathways

Primary genotoxicity in the liver following pulmonary exposure to carbon black nanoparticles in mice

(2018) Justyna Modrzynska et al.   Particle and Fibre Toxicology

Impact of anatase titanium dioxide nanoparticles on mutagenic and genotoxic response in Chinese hamster lung fibroblast cells (V-79): The role of cellular uptake

(2017) Abhishek Kumar Jain et al.   FOOD AND CHEMICAL TOXICOLOGY

A critical role of TRPM2 channel in Aβ42 -induced microglial activation and generation of tumor necrosis factor-α

(2017) Sharifah Alawieyah Syed Mortadza et al.   GLIA

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

Involvement of PINK1/parkin-mediated mitophagy in ZnO nanoparticle-induced toxicity in BV-2 cells

(2017) Limin Wei et al.   International Journal of Nanomedicine

Systemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intravenous 28 days repeated dose toxicity study

(2017) Ting Zhang et al.   International Journal of Nanomedicine

Combustion-Derived Nanoparticles in Key Brain Target Cells and Organelles in Young Urbanites: Culprit Hidden in Plain Sight in Alzheimer’s Disease Development

(2017) Angélica González-Maciel et al.   JOURNAL OF ALZHEIMERS DISEASE

Toxicity of inhaled particulate matter on the central nervous system: neuroinflammation, neuropsychological effects and neurodegenerative disease

(2017) Yan Wang et al.   JOURNAL OF APPLIED TOXICOLOGY

Neuronal P2X7 Receptor: Involvement in Neuronal Physiology and Pathology

(2017) M. Teresa Miras-Portugal et al.   JOURNAL OF NEUROSCIENCE

Prenatal exposure to nanosized zinc oxide in rats: neurotoxicity and postnatal impaired learning and memory ability

(2017) Feng Xiaoli et al.   Nanomedicine

Central neurotoxicity induced by the instillation of ZnO and TiO2 nanoparticles through the taste nerve pathway

(2017) Chen Aijie et al.   Nanomedicine

Evidence of nose-to-brain delivery of nanoemulsions: cargoes but not vehicles

(2017) Ejaj Ahmad et al.   Nanoscale

Oral subchronic exposure to silver nanoparticles causes renal damage through apoptotic impairment and necrotic cell death

(2017) Ratnakar Tiwari et al.   Nanotoxicology

In situ quantification of diverse titanium dioxide nanoparticles unveils selective endoplasmic reticulum stress-dependent toxicity

(2017) Marina Simon et al.   Nanotoxicology

March, 2017 Look Inside ToxSci

(2017)   TOXICOLOGICAL SCIENCES

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

(2017) Farraj Albalawi et al.   Frontiers in Cellular Neuroscience

Uniform TiO2 nanoparticles induce apoptosis in epithelial cell lines in a size-dependent manner

(2017) Qingqing Sun et al.   Biomaterials Science

Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis

(2017) Susanna Amadio et al.   Frontiers in Immunology

Lipopolysaccharide Adsorbed to the Bio-Corona of TiO2 Nanoparticles Powerfully Activates Selected Pro-inflammatory Transduction Pathways

(2017) Massimiliano G. Bianchi et al.   Frontiers in Immunology

Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation

(2016) Ming Xu et al.   ACS Nano

Nanoscale effects in dendrimer-mediated targeting of neuroinflammation

(2016) Elizabeth Nance et al.   BIOMATERIALS

Size-Dependent Deposition, Translocation, and Microglial Activation of Inhaled Silver Nanoparticles in the Rodent Nose and Brain

(2016) Esther Shin Patchin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Iron oxide nanoparticles modulate lipopolysaccharide-induced inflammatory responses in primary human monocytes

(2016) Susan Grosse et al.   International Journal of Nanomedicine

Metal oxide nanoparticles interact with immune cells and activate different cellular responses

(2016) Rosana Simón-Vázquez et al.   International Journal of Nanomedicine

Nanosized titanium dioxide resulted in the activation of TGF-β/Smads/p38MAPK pathway in renal inflammation and fibration of mice

(2016) F Hong et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Inflammatory MAPK and NF-κB signaling pathways differentiated hepatitis potential of two agglomerated titanium dioxide particles

(2016) Jin Chen et al.   JOURNAL OF HAZARDOUS MATERIALS

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Store-Operated Ca2+ Entry (SOCE) and Purinergic Receptor-Mediated Ca2+ Homeostasis in Murine bv2 Microglia Cells: Early Cellular Responses to ATP-Mediated Microglia Activation

(2016) Daniel F. Gilbert et al.   Frontiers in Molecular Neuroscience

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling

(2015) Ji-Won Park et al.   Nanotoxicology

Neurotoxicity induced by zinc oxide nanoparticles: age-related differences and interaction

(2015) Lei Tian et al.   Scientific Reports

Investigating the immunomodulatory nature of zinc oxide nanoparticles at sub-cytotoxic levels in vitro and after intranasal instillation in vivo

(2015) Shruti R Saptarshi et al.   JOURNAL OF NANOBIOTECHNOLOGY

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

(2014) Chu-Hsin Shieh et al.   GLIA

Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants

(2014) Kaveh Memarzadeh et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Ca 2+ spiking activity caused by the activation of store-operated Ca 2+ channels mediates TNF-α release from microglial cells under chronic purinergic stimulation

(2013) Masayuki Ikeda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A systems toxicology approach to the surface functionality control of graphene–cell interactions

(2013) Nivedita Chatterjee et al.   BIOMATERIALS

Effects of sub-acute exposure to TiO2, ZnO and Al2O3nanoparticles on oxidative stress and histological changes in mouse liver and brain

(2013) Rupal Shrivastava et al.   DRUG AND CHEMICAL TOXICOLOGY

Angiotensin-(1–7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling

(2013) Elizabeth D. Moore et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute toxicity of zinc oxide nanoparticles to the rat olfactory system after intranasal instillation

(2013) Lifeng Gao et al.   JOURNAL OF APPLIED TOXICOLOGY

Differential Toxicity of Rod and Spherical Zinc Oxide Nanoparticles on Human Peripheral Blood Mononuclear Cells

(2013) Debalina Bhattacharya et al.   Journal of Biomedical Nanotechnology

Selective Impairment of P2Y Signaling by Prostaglandin E2 in Macrophages: Implications for Ca2+-Dependent Responses

(2013) P. G. Traves et al.   JOURNAL OF IMMUNOLOGY

Prenatal exposure to zinc oxide particles alters monoaminergic neurotransmitter levels in the brain of mouse offspring

(2013) Yuka Okada et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Modulation of the pharmacokinetics of zinc oxide nanoparticles and their fates in vivo

(2013) Hee-Jeong Paek et al.   Nanoscale

Cardiopulmonary toxicity of pulmonary exposure to occupationally relevant zinc oxide nanoparticles

(2013) Hsiao-Chi Chuang et al.   Nanotoxicology

Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration

(2013) Wan-Seob Cho et al.   Particle and Fibre Toxicology

Mechanism of Photogenerated Reactive Oxygen Species and Correlation with the Antibacterial Properties of Engineered Metal-Oxide Nanoparticles

(2012) Yang Li et al.   ACS Nano

Association of zinc ion release and oxidative stress induced by intratracheal instillation of ZnO nanoparticles to rat lung

(2012) Hiroko Fukui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Brain Protection from Stroke with Intravenous TNFα Decoy Receptor-Trojan Horse Fusion Protein

(2012) Rachita K Sumbria et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Demonstration of an Olfactory Bulb–Brain Translocation Pathway for ZnO Nanoparticles in Rodent Cells In Vitro and In Vivo

(2012) Yi-Yun Kao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status

(2012) Morag Prach et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

(2012) Yosuke Kurashima et al.   Nature Communications

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Quantum dots trigger immunomodulation of the NFκB pathway in human skin cells

(2011) Amelia A. Romoser et al.   MOLECULAR IMMUNOLOGY

The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles

(2011) Lili Zhang et al.   Nanotoxicology

Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice

(2011) Ching-Hao Li et al.   Nanotoxicology

Inflammatory responses of RAW 264.7 macrophages upon exposure to nanoparticles: Role of ROS-NFκB signaling pathway

(2011) Reddy P. Nishanth et al.   Nanotoxicology

Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms

(2011) Agnes M Scherbart et al.   Particle and Fibre Toxicology

Nose-to-Brain Transport Pathways of Wheat Germ Agglutinin Conjugated PEG-PLA Nanoparticles

(2011) Qingfeng Liu et al.   PHARMACEUTICAL RESEARCH

Models for oral uptake of nanoparticles in consumer products

(2011) Eleonore Fröhlich et al.   TOXICOLOGY

Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure

(2011) Yun Wang et al.   TOXICOLOGY LETTERS

Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping

(2010) Saji George et al.   ACS Nano

Phosphorylation of p65 Is Required for Zinc Oxide Nanoparticle–Induced Interleukin 8 Expression in Human Bronchial Epithelial Cells

(2010) Weidong Wu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

(2010) Miho Shiratori et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles

(2009) Chuan-Chin Huang et al.   TOXICOLOGY IN VITRO

Mechanisms of unmodified CdSe quantum dot-induced elevation of cytoplasmic calcium levels in primary cultures of rat hippocampal neurons

(2008) Mingliang Tang et al.   BIOMATERIALS

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE

Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles

(2008) Jiangxue Wang et al.   TOXICOLOGY

Expression and function of the P2X7 receptor in rat C6 glioma cells

(2007) Wei Wei et al.   CANCER LETTERS