The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

The P2X7 receptor links mechanical strain to cytokine IL-6 up-regulation and release in neurons and astrocytes

(2017) Wennan Lu et al.   JOURNAL OF NEUROCHEMISTRY

Inflammasome Priming in Sterile Inflammatory Disease

(2017) Meghana N. Patel et al.   TRENDS IN MOLECULAR MEDICINE

Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective

(2016) Jason C. Lim et al.   Frontiers in Cellular Neuroscience

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

Astrocyte Structural and Molecular Response to Elevated Intraocular Pressure Occurs Rapidly and Precedes Axonal Tubulin Rearrangement within the Optic Nerve Head in a Rat Model

(2016) Shandiz Tehrani et al.   PLoS One

Involvement of P2X7 receptor in neuronal degeneration triggered by traumatic injury

(2016) Francisco M. Nadal-Nicolás et al.   Scientific Reports

NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes

(2015) Sorina Georgiana Boaru et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse

(2015) Jonathan G. Crowston et al.   EXPERIMENTAL EYE RESEARCH

K+Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+Signaling

(2015) Michael A. Katsnelson et al.   JOURNAL OF IMMUNOLOGY

The pathogenic role of the inflammasome in neurodegenerative diseases

(2015) Leslie C. Freeman et al.   JOURNAL OF NEUROCHEMISTRY

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

(2015) Wei Chi et al.   Journal of Neuroinflammation

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity

(2015) Özlem Yilmaz et al.   PERIODONTOLOGY 2000

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Role of P2X7 and P2Y 2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation “ in vivo ” by P2X7 receptor

(2015) M. Teresa Miras-Portugal et al.   Computational and Structural Biotechnology Journal

Purines in the eye: Recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland

(2014) Julie Sanderson et al.   EXPERIMENTAL EYE RESEARCH

Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain

(2014) Jonathan M. Beckel et al.   GLIA

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP

(2014) E.E. Coffey et al.   NEUROSCIENCE

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X7 receptor: an emerging target in central nervous system diseases

(2014) Beáta Sperlágh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Purinergic regulation of inflammasome activation after central nervous system injury

(2012) Louis-Philippe Bernier   JOURNAL OF GENERAL PHYSIOLOGY

Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris

(2012) Sonia Guha et al.   JOURNAL OF NEUROCHEMISTRY

Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7receptors

(2012) Jingsheng Xia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis

(2012) Deepak Kumar Kaushik et al.   PLoS One

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

(2012) Donald E. Kimbler et al.   PLoS One

Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts

(2011) Marianela Masin et al.   BRITISH JOURNAL OF PHARMACOLOGY

P2X7 receptor positively regulates MyD88-dependent NF-κB activation

(2011) Yanhui Liu et al.   CYTOKINE

Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma

(2011) Ang Li et al.   EXPERIMENTAL EYE RESEARCH

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

(2011) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo

(2010) Huiling Hu et al.   EXPERIMENTAL EYE RESEARCH

Elevated hydrostatic pressure activates sodium/hydrogen exchanger-1 in rat optic nerve head astrocytes

(2009) Amritlal Mandal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice

(2009) Prisca Honore et al.   BEHAVIOURAL BRAIN RESEARCH

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors

(2009) Diana L Donnelly-Roberts et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Friend or Foe? Resolving the Impact of Glial Responses in Glaucoma

(2009) Elaine C. Johnson et al.   JOURNAL OF GLAUCOMA

The P2X7 receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance

(2009) Claire H. Mitchell et al.   Purinergic Signalling

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels

(2008) D. Reigada et al.   NEUROSCIENCE

Mechanical Environment of the Optic Nerve Head in Glaucoma

(2008) J CRAWFORD DOWNS et al.   OPTOMETRY AND VISION SCIENCE