Mechanisms underlying UCP1 dependent and independent adipocyte thermogenesis

Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study

(2018) Alexander W. Fischer et al.   Molecular Metabolism

The Diverse Metabolic Roles of Peripheral Serotonin

(2017) Alyce M. Martin et al.   ENDOCRINOLOGY

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

(2017) Kenji Ikeda et al.   NATURE MEDICINE

Warming the mouse to model human diseases

(2017) Kirthana Ganeshan et al.   Nature Reviews Endocrinology

Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease

(2017) Matthias J. Betz et al.   Nature Reviews Endocrinology

Reconstitution ofUCP1using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity

(2017) Qiantao Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Regulation of the Thermogenic Adipose Program

(2017) Audrey Sambeat et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice

(2016) Marika Zietak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice

(2016) Joseph F. Pierre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

(2016) Jonathan Z. Long et al.   CELL

Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice

(2016) Lavanya Vishvanath et al.   Cell Metabolism

Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

(2016) Lynne E. Ramage et al.   Cell Metabolism

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

(2016) Takeshi Inagaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance

(2016) Mayte Alvarez-Crespo et al.   Molecular Metabolism

Myocardin-Related Transcription Factor A Regulates Conversion of Progenitors to Beige Adipocytes

(2015) Meghan E. McDonald et al.   CELL

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption

(2015) Xunde Wang et al.   Cell Metabolism

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Human Brown Adipose Tissue: What We Have Learned So Far

(2015) Matthias J. Betz et al.   DIABETES

Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations

(2015) Kristin I. Stanford et al.   DIABETES

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans

(2015) Mark J.W. Hanssen et al.   DIABETES

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

Regulation of systemic energy homeostasis by serotonin in adipose tissues

(2015) Chang-Myung Oh et al.   Nature Communications

Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat

(2015) Jean Z. Lin et al.   Cell Reports

Mitochondrial Retrograde Signaling Mediated by UCP2 Inhibits Cancer Cell Proliferation and Tumorigenesis

(2014) P. Esteves et al.   CANCER RESEARCH

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation

(2014) Emilio P. Mottillo et al.   JOURNAL OF LIPID RESEARCH

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

(2014) You-Ying Chau et al.   NATURE CELL BIOLOGY

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

(2014) Justin D Crane et al.   NATURE MEDICINE

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

Thyroid Hormone Regulation of Metabolism

(2014) Rashmi Mullur et al.   PHYSIOLOGICAL REVIEWS

Independent Stem Cell Lineages Regulate Adipose Organogenesis and Adipose Homeostasis

(2014) Yuwei Jiang et al.   Cell Reports

Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas

(2013) Robin P. da Silva et al.   BRITISH JOURNAL OF NUTRITION

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

(2013) Rachel J. Perry et al.   Cell Metabolism

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown adipose tissue dynamics in wild-type and UCP1-knockout mice: in vivo insights with magnetic resonance

(2013) Kirsten Grimpo et al.   JOURNAL OF LIPID RESEARCH

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Energy balance regulation by thyroid hormones at central level

(2013) Miguel López et al.   TRENDS IN MOLECULAR MEDICINE

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

(2012) Joan Sanchez-Gurmaches et al.   Cell Metabolism

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

(2012) A. Vitali et al.   JOURNAL OF LIPID RESEARCH

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

(2012) Naresh C Bal et al.   NATURE MEDICINE

Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction

(2012) David B. Ramsden et al.   Brain and Behavior

The metabolic burden of creatine synthesis

(2011) John T. Brosnan et al.   AMINO ACIDS

The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications

(2011) Bianca Marmontel de Souza et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Brown Adipose Tissue in Morbidly Obese Subjects

(2011) Guy H. E. J. Vijgen et al.   PLoS One

Adipose Acyl-CoA Synthetase-1 Directs Fatty Acids toward β-Oxidation and Is Required for Cold Thermogenesis

(2010) Jessica M. Ellis et al.   Cell Metabolism

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells

(2010) Christoph Lepper et al.   GENESIS

Brown Adipose Tissue, Whole-Body Energy Expenditure, and Thermogenesis in Healthy Adult Men

(2010) Takeshi Yoneshiro et al.   Obesity

Uncoupling protein 3 expression levels influence insulin sensitivity, fatty acid oxidation, and related signaling pathways

(2010) Rosalba Senese et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

(2010) T. J. Schulz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Expression of Uncoupling Protein 1 in Mouse Brown Adipose Tissue Is Thyroid Hormone Receptor-β Isoform Specific and Required for Adaptive Thermogenesis

(2009) Miriam O. Ribeiro et al.   ENDOCRINOLOGY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

(2008) Camille C. Caldeira da Silva et al.   AGING CELL

BMP7 influences proliferation, migration, and invasion of breast cancer cells

(2008) Emma-Leena Alarmo et al.   CANCER LETTERS

Global burden of obesity in 2005 and projections to 2030

(2008) T Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY

Inactivation of UCP1 and the Glycerol Phosphate Cycle Synergistically Increases Energy Expenditure to Resist Diet-induced Obesity

(2008) Rea Anunciado-Koza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T3-mediated expression of PGC-1α via a far upstream located thyroid hormone response element

(2008) Anne Wulf et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE