Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice

Bile Routing Modification Reproduces Key Features of Gastric Bypass in Rat

(2015) Daisy Goncalves et al.   ANNALS OF SURGERY

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Abdominal obesity: a marker of ectopic fat accumulation

(2015) Ulf Smith   JOURNAL OF CLINICAL INVESTIGATION

Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery

(2015) Charles Robb Flynn et al.   Nature Communications

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

(2015) Marc Schneeberger et al.   Scientific Reports

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

The different shades of fat

(2014) Vivian Peirce et al.   NATURE

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes

(2014) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

A Surgical Model in Male Obese Rats Uncovers Protective Effects of Bile Acids Post-Bariatric Surgery

(2013) Rohit Kohli et al.   ENDOCRINOLOGY

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity

(2013) N N Ahmad et al.   INTERNATIONAL JOURNAL OF OBESITY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Increased expression of oxidative enzymes in adipose tissue following PPARα-activation

(2013) Adaliene Versiani Matos Ferreira et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

Reprogramming of Intestinal Glucose Metabolism and Glycemic Control in Rats After Gastric Bypass

(2013) N. Saeidi et al.   SCIENCE

Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity

(2013) A. P. Liou et al.   Science Translational Medicine

The origin and definition of brite versus white and classical brown adipocytes

(2013) Matthias Rosenwald et al.   Adipocyte

Bile acids: From digestion to cancers

(2012) Marine Baptissart et al.   BIOCHIMIE

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Bile Acids Acutely Stimulate Insulin Secretion of Mouse  -Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition

(2012) M. Dufer et al.   DIABETES

The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

(2012) Dimitri J. Pournaras et al.   ENDOCRINOLOGY

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

(2012) Emilio P. Mottillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local and systemic response to intramammary lipopolysaccharide challenge during long-term manipulated plasma glucose and insulin concentrations in dairy cows

(2012) M.C.M.B. Vernay et al.   JOURNAL OF DAIRY SCIENCE

The importance of the gut microbiota after bariatric surgery

(2012) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

Groundtruthing Next-Gen Sequencing for Microbial Ecology–Biases and Errors in Community Structure Estimates from PCR Amplicon Pyrosequencing

(2012) Charles K. Lee et al.   PLoS One

Antibody-Mediated Inhibition of Fibroblast Growth Factor 19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys

(2012) Rama Pai et al.   TOXICOLOGICAL SCIENCES

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

(2012) Taoufiq Harach et al.   Scientific Reports

Assessment of Different Bariatric Surgeries in the Treatment of Obesity and Insulin Resistance in Mice

(2011) Deng Ping Yin et al.   ANNALS OF SURGERY

Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells

(2011) Juan Ignacio Barrasa et al.   APOPTOSIS

Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion

(2011) HE Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

(2011) J. Prawitt et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure

(2011) Mitsuhiro Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Effects of Laparoscopic Gastric Band Applications on Plasma and Fundic Acylated Ghrelin Levels in Morbidly Obese Patients

(2011) Remise Gelisgen et al.   OBESITY SURGERY

Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?

(2010) Filip K. Knop   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities

(2010) Rohit Kohli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut Hypertrophy After Gastric Bypass Is Associated With Increased Glucagon-Like Peptide 2 and Intestinal Crypt Cell Proliferation

(2010) Carel W. le Roux et al.   ANNALS OF SURGERY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Human gut microbiota in obesity and after gastric bypass

(2009) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent Correlation of Ghrelin Plasma Levels with Body Mass Index Both in Stable Weight Conditions and during Gastric-bypass-induced Weight Loss

(2008) J. Ybarra et al.   OBESITY SURGERY

Plasma Ghrelin Modulation in Gastric Band Operation and Sleeve Gastrectomy

(2008) Yong Wang et al.   OBESITY SURGERY