ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models

AMPK Phosphorylation of ACE2 in Endothelium Mitigates Pulmonary Hypertension

(2018) Jiao Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response

(2018) Friederike Klempin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Excessive Glutamate Stimulation Impairs ACE2 Activity Through ADAM17-Mediated Shedding in Cultured Cortical Neurons

(2018) Jiaxi Xu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Angiotensin-converting enzyme 2 and renal disease

(2018) Vanessa R. Williams et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Neuroprotection by post-stroke administration of an oral formulation of angiotensin-(1-7) in ischaemic stroke

(2018) Douglas M. Bennion et al.   EXPERIMENTAL PHYSIOLOGY

Coupling corticotropin-releasing-hormone and angiotensin converting enzyme 2 dampens stress responsiveness in male mice

(2018) Lei A. Wang et al.   NEUROPHARMACOLOGY

The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

(2018) Robson Augusto Souza Santos et al.   PHYSIOLOGICAL REVIEWS

Chronic overexpression of angiotensin-(1-7) in rats reduces cardiac reactivity to acute stress and dampens anxious behavior

(2017) Danielle Moura Santos et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

(2016) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes

(2016) Kashyap A. Patel et al.   DIABETES

Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise

(2016) Daisy Motta-Santos et al.   HYPERTENSION RESEARCH

Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors

(2016) Lei Wang et al.   NEUROPHARMACOLOGY

Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress

(2016) Luiza A. Rabelo et al.   PLoS One

Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress

(2015) Huijing Xia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Neuroprotective Mechanisms of the ACE2–Angiotensin-(1-7)–Mas Axis in Stroke

(2015) Douglas M. Bennion et al.   CURRENT HYPERTENSION REPORTS

Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia

(2015) Yan Fei Qi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Angiotensin-Converting Enzyme 2 Decreases Formation and Severity of Angiotensin II–Induced Abdominal Aortic Aneurysms

(2014) Sean E. Thatcher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiotensin Converting Enzyme 2/Ang-(1-7)/Mas Axis Protects Brain from Ischemic Injury with a Tendency of Age-dependence

(2014) Jiao-Lin Zheng et al.   CNS Neuroscience & Therapeutics

The ACE2/Ang-(1–7)/Mas axis can inhibit hepatic insulin resistance

(2014) Xi Cao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neuronal over-expression of ACE2 protects brain from ischemia-induced damage

(2014) Ji Chen et al.   NEUROPHARMACOLOGY

Activation of the ACE2/Ang-(1–7)/Mas pathway reduces oxygen–glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction

(2014) J. Zheng et al.   NEUROSCIENCE

Generation of outbred Ace2 knockout mice by RNA transfection of TALENs displaying colitis reminiscent pathophysiology and inflammation

(2014) Chuxin Liu et al.   TRANSGENIC RESEARCH

Angiotensin-(1-7) attenuates the anxiety and depression-like behaviors in transgenic rats with low brain angiotensinogen

(2013) Lucas M. Kangussu et al.   BEHAVIOURAL BRAIN RESEARCH

Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation

(2013) Makoto Sahara et al.   CARDIOVASCULAR RESEARCH

Brain Angiotensin-Converting Enzyme Type 2 Shedding Contributes to the Development of Neurogenic Hypertension

(2013) Huijing Xia et al.   CIRCULATION RESEARCH

Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats

(2013) Robert W. Regenhardt et al.   EXPERIMENTAL PHYSIOLOGY

Serotonin Is Required for Exercise-Induced Adult Hippocampal Neurogenesis

(2013) F. Klempin et al.   JOURNAL OF NEUROSCIENCE

Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke

(2013) Robert W. Regenhardt et al.   NEUROPHARMACOLOGY

Loss of ACE2 Exacerbates Murine Renal Ischemia-Reperfusion Injury

(2013) Fei Fang et al.   PLoS One

Defective intestinal amino acid absorption in Ace2 null mice

(2012) Dustin Singer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Suppressing inflammation by inhibiting the NF-κB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia

(2012) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system

(2012) Robson A S Santos et al.   JOURNAL OF ENDOCRINOLOGY

Emergence and evolution of the renin–angiotensin–aldosterone system

(2012) David Fournier et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice

(2012) Renisha Nadarajah et al.   KIDNEY INTERNATIONAL

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

Role of angiotensin-converting enzyme (ACE and ACE2) imbalance on tourniquet-induced remote kidney injury in a mouse hindlimb ischemia–reperfusion model

(2012) Xiu-hong Yang et al.   PEPTIDES

Angiotensin-Converting Enzyme 2 Over-Expression in the Central Nervous System Reduces Angiotensin-II-Mediated Cardiac Hypertrophy

(2012) Yumei Feng et al.   PLoS One

Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke

(2011) Adam P. Mecca et al.   EXPERIMENTAL PHYSIOLOGY

Brain-Selective Overexpression of Angiotensin-Converting Enzyme 2 Attenuates Sympathetic Nerve Activity and Enhances Baroreflex Function in Chronic Heart Failure

(2011) Liang Xiao et al.   HYPERTENSION

Angiotensin-(1–7)/Mas axis integrity is required for the expression of object recognition memory

(2011) Thiago L.N. Lazaroni et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

ACE2-Mediated Reduction of Oxidative Stress in the Central Nervous System Is Associated with Improvement of Autonomic Function

(2011) Huijing Xia et al.   PLoS One

Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy

(2010) Michael Bader   Annual Review of Pharmacology and Toxicology

Genetic Ace2 Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the ApoE Knockout Mouse

(2010) Merlin C. Thomas et al.   CIRCULATION RESEARCH

Brain-Selective Overexpression of Human Angiotensin-Converting Enzyme Type 2 Attenuates Neurogenic Hypertension

(2009) Yumei Feng et al.   CIRCULATION RESEARCH

Genetically altered animals in the study of the metabolic functions of peptide hormone systems

(2009) Marcelo Alves-da-Silva Mori et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis

(2008) Fina Lovren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Transgenic Angiotensin-Converting Enzyme 2 Overexpression in Vessels of SHRSP Rats Reduces Blood Pressure and Improves Endothelial Function

(2008) Brit Rentzsch et al.   HYPERTENSION

Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2

(2008) J. Netland et al.   JOURNAL OF VIROLOGY

Angiotensin-converting enzyme 2 and new insights into the renin–angiotensin system

(2007) Daniel W. Lambert et al.   BIOCHEMICAL PHARMACOLOGY

Genetically altered animal models for Mas and angiotensin-(1-7)

(2007) Natalia Alenina et al.   EXPERIMENTAL PHYSIOLOGY