Neuroprotective Mechanisms of the ACE2–Angiotensin-(1-7)–Mas Axis in Stroke

Direct evidence of intracrine angiotensin II signaling in neurons

(2014) Elena Deliu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Promising neuroprotective effects of the angiotensin-(1-7)-angiotensin-converting enzyme 2-Mas axis in stroke

(2014) Ricardo A. Peña Silva et al.   EXPERIMENTAL PHYSIOLOGY

Diminazene aceturate (Berenil), a new use for an old compound?

(2014) Shiby Kuriakose et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke

(2014) Jason P. Joseph et al.   NEUROPHARMACOLOGY

Neuronal over-expression of ACE2 protects brain from ischemia-induced damage

(2014) Ji Chen et al.   NEUROPHARMACOLOGY

Activation of the ACE2/Ang-(1–7)/Mas pathway reduces oxygen–glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction

(2014) J. Zheng et al.   NEUROSCIENCE

Direct Angiotensin AT2 Receptor Stimulation Using a Novel AT2 Receptor Agonist, Compound 21, Evokes Neuroprotection in Conscious Hypertensive Rats

(2014) Claudia A. McCarthy et al.   PLoS One

ACE2/Ang-(1–7) signaling and vascular remodeling

(2014) ZhenZhou Zhang et al.   Science China-Life Sciences

Cerebroprotective action of angiotensin peptides in stroke

(2013) Robert W. Regenhardt et al.   CLINICAL SCIENCE

ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke

(2013) Teng Jiang et al.   Current Neuropharmacology

Angiotensin-(1–7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling

(2013) Elizabeth D. Moore et al.   FREE RADICAL BIOLOGY AND MEDICINE

Angiotensin-Converting Enzyme 2 Activation Improves Endothelial Function

(2013) Rodrigo A. Fraga-Silva et al.   HYPERTENSION

Possible Role of Angiotensin-Converting Enzyme 2 and Activation of Angiotensin II Type 2 Receptor by Angiotensin-(1–7) in Improvement of Vascular Remodeling by Angiotensin II Type 1 Receptor Blockade

(2013) Kousei Ohshima et al.   HYPERTENSION

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS

(2013) Vaibhav B. Patel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas

(2013) Concepción Peiró et al.   JOURNAL OF PHYSIOLOGY-LONDON

ACE2 Activation Confers Endothelial Protection and Attenuates Neointimal Lesions in Prevention of Severe Pulmonary Arterial Hypertension in Rats

(2013) Gang Li et al.   LUNG

Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke

(2013) Robert W. Regenhardt et al.   NEUROPHARMACOLOGY

Oral Angiotensin-(1–7) prevented obesity and hepatic inflammation by inhibition of resistin/TLR4/MAPK/NF-κB in rats fed with high-fat diet

(2013) Sérgio Henrique Sousa Santos et al.   PEPTIDES

Angiotensin-(1-7) inhibits vascular calcification in rats

(2013) Yu-Bin Sui et al.   PEPTIDES

Preclinical Stroke Research: Gains and Gaps

(2013) D. A. Greenberg   STROKE

Guidelines for the Early Management of Patients With Acute Ischemic Stroke

(2013) Edward C. Jauch et al.   STROKE

Angiotensin converting enzyme 2 and atherosclerosis

(2012) Yutang Wang et al.   ATHEROSCLEROSIS

Angiotensin-(1–7) regulates Angiotensin II-induced VCAM-1 expression on vascular endothelial cells

(2012) Feng Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiotensin-(1-7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1/2- and NF-κB-dependent pathways

(2012) Ahmed Z El-Hashim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Suppressing inflammation by inhibiting the NF-κB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia

(2012) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Angiotensin-(1–7): beyond the cardio-renal actions

(2012) Danielle G. Passos-Silva et al.   CLINICAL SCIENCE

Angiotensin II Type 2 Receptor Stimulation Initiated After Stroke Causes Neuroprotection in Conscious Rats

(2012) Claudia A. McCarthy et al.   HYPERTENSION

Angiotensin-Converting Enzyme 2 Priming Enhances the Function of Endothelial Progenitor Cells and Their Therapeutic Efficacy

(2012) Ji Chen et al.   HYPERTENSION

Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors

(2012) Florian Gembardt et al.   HYPERTENSION RESEARCH

Angiotensin-(1-7) modulates renin–angiotensin system associated with reducing oxidative stress and attenuating neuronal apoptosis in the brain of hypertensive rats

(2012) Teng Jiang et al.   PHARMACOLOGICAL RESEARCH

Reducing the Global Burden of Ischemic Heart Disease and Stroke

(2011) Sidney C. Smith   CIRCULATION

Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist

(2011) Roelie M Wösten-van Asperen et al.   JOURNAL OF PATHOLOGY

Differential Mechanisms of Ang (1-7)-Mediated Vasodepressor Effect in Adult and Aged Candesartan-Treated Rats

(2011) S. Bosnyak et al.   International Journal of Hypertension

Angiotensin-(1-7) and low-dose angiotensin II infusion reverse salt-induced endothelial dysfunction via different mechanisms in rat middle cerebral arteries

(2010) Matthew J. Durand et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin-(1–7) upregulates cardiac nitric oxide synthase in spontaneously hypertensive rats

(2010) María A. Costa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

ACE2/ANG-(1–7)/Mas pathway in the brain: the axis of good

(2010) Ping Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Vasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E–Deficient Mice

(2010) Sonja Tesanovic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiotensin type 1 receptor antagonist inhibits lipopolysaccharide-induced stimulation of rat microglial cells by suppressing nuclear factor κB and activator protein-1 activation

(2010) Michio Miyoshi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Angiotensin II sustains brain inflammation in mice via TGF-β

(2010) Tobias V. Lanz et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Inflammatory Effects of the Activation of the Angiotensin-(1-7) Receptor, Mas, in Experimental Models of Arthritis

(2010) K. D. da Silveira et al.   JOURNAL OF IMMUNOLOGY

Evidence for Angiotensin-converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension

(2009) Anderson J. Ferreira et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phase I and Pharmacokinetic Study of Angiotensin-(1-7), an Endogenous Antiangiogenic Hormone

(2009) W. J. Petty et al.   CLINICAL CANCER RESEARCH

Candesartan pretreatment is cerebroprotective in a rat model of endothelin-1-induced middle cerebral artery occlusion

(2009) Adam P. Mecca et al.   EXPERIMENTAL PHYSIOLOGY

Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage

(2009) Paolo Gelosa et al.   JOURNAL OF HYPERTENSION

Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway

(2008) Vijay Koka et al.   AMERICAN JOURNAL OF PATHOLOGY

MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides

(2008) Patricia E. Gallagher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effects of intracerebroventricular infusion of angiotensin-(1–7) on bradykinin formation and the kinin receptor expression after focal cerebral ischemia–reperfusion in rats

(2008) Jie Lu et al.   BRAIN RESEARCH

Transgenic Angiotensin-Converting Enzyme 2 Overexpression in Vessels of SHRSP Rats Reduces Blood Pressure and Improves Endothelial Function

(2008) Brit Rentzsch et al.   HYPERTENSION

Central administration of angiotensin-(1–7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia/reperfusion in rats

(2008) Yingdong Zhang et al.   NEUROPEPTIDES

Neuroprotection for ischemic stroke: Past, present and future

(2008) Myron D. Ginsberg   NEUROPHARMACOLOGY