Article
Food Science & Technology
Yaozhong Hu, Jiaxin Gu, Jing Lin, Yi Wang, Feier Yang, Jia Yin, Zhenting Yu, Sihao Wu, Huan Lv, Xuemeng Ji, Shuo Wang
Summary: The intervention of EGCG on macrophage polarization was found to promote M2 polarization and inhibit M1 polarization, particularly in liver, colon, spleen, and brain.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Hua-Yu Hsu, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Huey-Ling You, Yu-Chih Lin, Wei-Ting Liao, Yi-Ching Lin
Summary: Arsenic can promote macrophage polarization to M2 type, resulting in the epithelial-mesenchymal transition of lung epithelial cells. This study found that arsenic induces repolarization of M1 macrophages to M2 macrophages through the autophagy/mitophagy pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Guang-Ping Lang, Can Li, Ying-Ying Han
Summary: Pretreatment with rutin can promote the phenotypic switch of microglia from M1 to M2 by inhibiting the Toll-like receptor 4/nuclear factor-κB signaling pathway to alleviate lipopolysaccharide-induced neuroinflammation.
NEURAL REGENERATION RESEARCH
(2021)
Article
Immunology
Minni Zhang, Kun Liu, Qiuyue Zhang, Junnv Xu, Jinchen Liu, Haifeng Lin, Bo Lin, Mingyue Zhu, Mengsen Li
Summary: The role of AFP in regulating macrophage function and phagocytosis is still unclear. This study explored the correlation between AFP regulation of macrophages and the possible regulatory mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Patricia Figueiredo, Anni Lepland, Pablo Scodeller, Flavia Fontana, Giulia Torrieri, Mattia Tiboni, Mohammad-Ali Shahbazi, Luca Casettari, Mauri A. Kostiainen, Jouni Hirvonen, Tambet Teesalu, Helder A. Santos
Summary: Nanomedicines are innovative technologies that improve the therapeutic effects of drugs for cancer treatment by targeting M2-like tumor-associated macrophages and modulating the tumor microenvironment.
ACTA BIOMATERIALIA
(2021)
Article
Immunology
Peiwu Ding, Jie Liu, Yidi Meng, Hongfei Wang, Yun Huang, Guanhua Su, Chaorui Xia, Xinling Du, Nianguo Dong, Tianpen Cui, Jiaming Zhang, Jingdong Li
Summary: The study found that MFG-E8 and CaMKII may collaboratively regulate myocardial remodeling and M1/M2 macrophage polarization after MI. MFG-E8 can inhibit the polarization of M1 macrophages and promote the polarization of M2 macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Qi Lv, Yao Xing, Yijun Liu, Qingzhu Chen, Jingyi Xu, Lihong Hu, Yinan Zhang
Summary: Our study demonstrates that didymin can alleviate clinical symptoms of colitis in mice by modulating macrophage phenotypes. Mechanistic studies reveal that didymin induces the conversion of pro-inflammatory M1-like macrophages to anti-inflammatory M2-like macrophages through enhancing fatty acid oxidation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Xiaoran Ma, Shuang Wang, Chenglin Li, Xihui Jia, Tiantian Wang, Zhe Leng, Ran Lu, Xiaowen Kong, Jinyu Zhang, Ling Li
Summary: Baicalein (BAI), a natural flavonoid, has been found to alleviate clinical symptoms, demyelination, and inflammatory response in EAE mice. It inhibits M1 microglia/macrophage activation, decreases the expression of proinflammatory cytokines, and targets STAT1 to inhibit polarization. These findings suggest the potential use of BAI in the treatment of MS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Sri Murugan Poongkavithai Vadevoo, Gowri Rangaswamy Gunassekaran, Jae Do Yoo, Tae-Hwan Kwon, Keun Hur, Sehyun Chae, Byungheon Lee
Summary: This study demonstrates the reprogramming of M2-type tumor-associated macrophages into an M1-like phenotype using epigenetic therapy, specifically the combination of 5-aza-2'-deoxycytidine and trichostatin A. This combination treatment decreases M2 macrophage cytokines and increases M1 macrophage cytokines, sensitizing tumor cells to paclitaxel and inhibiting tumor growth. miR-7083-5p is identified as a key player in this reprogramming process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ryoka Uchiyama, Eriko Toyoda, Miki Maehara, Shiho Wasai, Haruka Omura, Masahiko Watanabe, Masato Sato
Summary: PRP purified using commercial kits can affect macrophage polarization, with APS having a higher concentration of M1 and M2 macrophage related factors. When PRP supernatants were added to monocyte-derived macrophages and M1 polarized macrophages, it was observed that PRPs suppressed M1 macrophage polarization and promoted M2 macrophage polarization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ruyi Qu, Mengxian Zhou, Yan Qiu, Yuan Peng, Xuewei Yin, Bin Liu, Hongsheng Bi, Yan'e Gao, Dadong Guo
Summary: Research has shown that glucocorticoids can modulate the balance of M1/M2 macrophage polarization through the p38MAPK-MEF2C axis in experimental autoimmune uveitis, leading to the suppression of ocular inflammation. This study elucidates the mechanism of glucocorticoids in treating uveitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Jia Li, Shanshan Yu, Xi Lu, Kaixuan Cui, Xiaoyu Tang, Yue Xu, Xiaoling Liang
Summary: This study investigated the role and regulatory mechanism of M1/M2 microglia/macrophage in oxygen-induced retinopathy (OIR). The results showed that M1 microglia/macrophage were activated in neovascularization tufts in both central and peripheral retina during the early phase of OIR, while M2 phenotype took over during the late phase, leading to the regression of neovascular tufts.
INFLAMMATION RESEARCH
(2021)
Review
Immunology
Maurizio Cutolo, Rosanna Campitiello, Emanuele Gotelli, Stefano Soldano
Summary: This article discusses the balance between innate and adaptive immunity in autoimmune rheumatic diseases, specifically rheumatoid arthritis, and its impact on the inflammatory process and clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Kejun Peng, Nianhua Deng, Yao Meng, Qianchuan He, Hao Meng, Ting Luo, Yanru Wei, Yue Kang, Xiaodong Zhou, Fubing Shen
Summary: Alpha-MMC can regulate the immune system by inhibiting the expression of inflammatory cytokines without affecting anti-inflammatory cytokines. The findings suggest that Alpha-MMC may be a potential treatment for severe inflammation and autoimmune diseases characterized by cytokine storms.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Engineering, Biomedical
Claire E. Witherel, Kimheak Sao, Becky K. Brisson, Biao Han, Susan W. Volk, Ryan J. Petrie, Lin Han, Kara L. Spiller
Summary: This study investigates the role of macrophages in ECM assembly, showing that the phenotype of macrophages influences the formation and characteristics of fibrous tissues. By designing gelatin hydrogels containing cytokines, the shift in macrophage phenotype was promoted to affect the ECM composition and architecture.