Cdt1 variants reveal unanticipated aspects of interactions with cyclin/CDK and MCM important for normal genome replication

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

(2017) Yuanliang Zhai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

(2017) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cdt1 stabilizes an open MCM ring for helicase loading

(2017) Jordi Frigola et al.   Nature Communications

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

(2017) Yuanliang Zhai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

(2017) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rapid DNA replication origin licensing protects stem cell pluripotency

(2017) Jacob Peter Matson et al.   eLife

Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex

(2016) Zhiying You et al.   CELL CYCLE

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells

(2016) Alberto Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability

(2016) Pedro Pozo et al.   Genes

De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome

(2015) Lindsay C. Burrage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Simultaneous measurement of passage through the restriction point and MCM loading in single cells

(2015) T. W. Håland et al.   NUCLEIC ACIDS RESEARCH

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally

(2013) M. Yekezare et al.   JOURNAL OF CELL SCIENCE

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

(2013) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing

(2013) Philippe Coulombe et al.   Nature Communications

Meier–Gorlin syndrome genotype–phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis

(2012) Sonja A de Munnik et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

(2012) D. McIntosh et al.   Cold Spring Harbor Perspectives in Biology

Replication licensing promotes cyclin D1 expression and G1progression in untransformed human cells

(2011) Peijun Liu et al.   CELL CYCLE

Origin licensing and p53 status regulate Cdk2 activity during G1

(2011) Kathleen R. Nevis et al.   CELL CYCLE

CRL4Cdt2

(2011) Tarek Abbas et al.   CELL CYCLE

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

(2011) C. G. Havens et al.   GENES & DEVELOPMENT

Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome

(2011) Duane L Guernsey et al.   NATURE GENETICS

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

Mutations in the pre-replication complex cause Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

How dormant origins promote complete genome replication

(2011) J. Julian Blow et al.   TRENDS IN BIOCHEMICAL SCIENCES

Prevention of DNA re-replication in eukaryotic cells

(2011) L. N. Truong et al.   Journal of Molecular Cell Biology

Replication licensing and the DNA damage checkpoint

(2010) Jeanette Gowen Cook   Frontiers in Bioscience-Landmark

Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins

(2010) JunGoo Jee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA replication licensing control and rereplication prevention

(2010) Chonghua Li et al.   Protein & Cell

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

(2009) V. De Marco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factors

(2009) Bulat I. Khayrutdinov et al.   PROTEIN SCIENCE

Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage

(2008) Jonathan R. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY