Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability

Mutations in CDC45 , Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis

(2016) Aimee L. Fenwick et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex

(2016) Zhiying You et al.   CELL CYCLE

Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA

(2016) Jasminka Boskovic et al.   CELL CYCLE

MCM: one ring to rule them all

(2016) Tom D Deegan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

DNA replication origins—where do we begin?

(2016) Marie-Noëlle Prioleau et al.   GENES & DEVELOPMENT

RB1: a prototype tumor suppressor and an enigma

(2016) Nicholas J. Dyson   GENES & DEVELOPMENT

USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication

(2016) Santiago Hernández-Pérez et al.   Molecular Oncology

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

(2016) Panagiotis Galanos et al.   NATURE CELL BIOLOGY

Targeting the RB-E2F pathway in breast cancer

(2016) J Johnson et al.   ONCOGENE

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells

(2016) Alberto Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing

(2016) Ruowen Zhang et al.   Oncotarget

De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome

(2015) Lindsay C. Burrage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

(2015) Simina Ticau et al.   CELL

Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle

(2015) S. K. Powell et al.   EMBO JOURNAL

Sequential replication-coupled destruction at G1/S ensures genome stability

(2015) Kate E. Coleman et al.   GENES & DEVELOPMENT

Overexpression of CDT1 Is a Predictor of Poor Survival in Patients with Hepatocellular Carcinoma

(2015) Dimitrios Karavias et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA

(2015) Julien Gros et al.   MOLECULAR CELL

Structure of the eukaryotic MCM complex at 3.8 Å

(2015) Ningning Li et al.   NATURE

High-throughput prediction of RNA, DNA and protein binding regions mediated by intrinsic disorder

(2015) Zhenling Peng et al.   NUCLEIC ACIDS RESEARCH

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture

(2015) Nozomi Sugimoto et al.   NUCLEIC ACIDS RESEARCH

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA

(2014) Stefan A. Samel et al.   GENES & DEVELOPMENT

CDK1-dependent Inhibition of the E3 Ubiquitin Ligase CRL4CDT2Ensures Robust Transition from S Phase to Mitosis

(2014) Lindsay F. Rizzardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prereplication-complex formation: a molecular double take?

(2014) Hasan Yardimci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Seeing is believing: The MCM2–7 helicase trapped in complex with its DNA loader

(2013) Alberto Riera et al.   CELL CYCLE

Multi-step Loading of Human Minichromosome Maintenance Proteins in Live Human Cells

(2013) Ioanna-Eleni Symeonidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally

(2013) M. Yekezare et al.   JOURNAL OF CELL SCIENCE

An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly

(2013) Alejandra Fernández-Cid et al.   MOLECULAR CELL

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

(2013) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Minichromosome Maintenance Replicative Helicase

(2013) S. D. Bell et al.   Cold Spring Harbor Perspectives in Biology

Chromatin and DNA Replication

(2013) D. M. MacAlpine et al.   Cold Spring Harbor Perspectives in Biology

Helicase Activation and Establishment of Replication Forks at Chromosomal Origins of Replication

(2013) S. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

DNA Replication Origins

(2013) A. C. Leonard et al.   Cold Spring Harbor Perspectives in Biology

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

Signaling Pathways that Control Cell Proliferation

(2013) R. J. Duronio et al.   Cold Spring Harbor Perspectives in Biology

A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing

(2013) Philippe Coulombe et al.   Nature Communications

Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis

(2013) Takaaki Tsunematsu et al.   Nature Communications

Transcriptional control of DNA replication licensing by Myc

(2013) Taras Valovka et al.   Scientific Reports

Activation of the replicative DNA helicase: breaking up is hard to do

(2012) Dominik Boos et al.   CURRENT OPINION IN CELL BIOLOGY

Endoreplication and polyploidy: insights into development and disease

(2012) D. T. Fox et al.   DEVELOPMENT

Regulation of DNA replication during development

(2012) J. Nordman et al.   DEVELOPMENT

Meier–Gorlin syndrome genotype–phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis

(2012) Sonja A de Munnik et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

(2012) Tina M. Thornton et al.   International Journal of Biological Sciences

Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

(2012) K. Klotz-Noack et al.   JOURNAL OF CELL SCIENCE

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

(2012) Alex J. Kuo et al.   NATURE

Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore–microtubule attachment

(2012) Dileep Varma et al.   NATURE CELL BIOLOGY

Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs

(2012) Emilie Besnard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate targeting by the ubiquitin–proteasome system in mitosis

(2012) Mingwei Min et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

(2012) D. McIntosh et al.   Cold Spring Harbor Perspectives in Biology

Origin licensing and p53 status regulate Cdk2 activity during G1

(2011) Kathleen R. Nevis et al.   CELL CYCLE

The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells 

(2011) Jingjing Zhang et al.   CELL CYCLE

CRL4Cdt2

(2011) Tarek Abbas et al.   CELL CYCLE

State of the APC/C: Organization, function, and structure

(2011) Janel R. McLean et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Geminin Escapes Degradation in G1 of Mouse Pluripotent Cells and Mediates the Expression of Oct4, Sox2, and Nanog

(2011) Valerie S. Yang et al.   CURRENT BIOLOGY

Nucleosomes in the neighborhood

(2011) Elizabeth Suzanne Dorn et al.   Epigenetics

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

(2011) C. G. Havens et al.   GENES & DEVELOPMENT

CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6

(2011) S. Chen et al.   GENES & DEVELOPMENT

Chromatin Remodeler Sucrose Nonfermenting 2 Homolog (SNF2H) Is Recruited onto DNA Replication Origins through Interaction with Cdc10 Protein-dependent Transcript 1 (Cdt1) and Promotes Pre-replication Complex Formation

(2011) Nozomi Sugimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-Stimulated Mitogen-Activated Protein Kinases Control the Stability and Activity of the Cdt1 DNA Replication Licensing Factor

(2011) S. Chandrasekaran et al.   MOLECULAR AND CELLULAR BIOLOGY

JNK1 Phosphorylation of Cdt1 Inhibits Recruitment of HBO1 Histone Acetylase and Blocks Replication Licensing in Response to Stress

(2011) Benoit Miotto et al.   MOLECULAR CELL

Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome

(2011) Duane L Guernsey et al.   NATURE GENETICS

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

Mutations in the pre-replication complex cause Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

Structural insights into the Cdt1-mediated MCM2–7 chromatin loading

(2011) Changdong Liu et al.   NUCLEIC ACIDS RESEARCH

Evolution of networks and sequences in eukaryotic cell cycle control

(2011) F. R. Cross et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

How dormant origins promote complete genome replication

(2011) J. Julian Blow et al.   TRENDS IN BIOCHEMICAL SCIENCES

Prevention of DNA re-replication in eukaryotic cells

(2011) L. N. Truong et al.   Journal of Molecular Cell Biology

Eukaryotic Chromosome DNA Replication: Where, When, and How?

(2010) Hisao Masai et al.   Annual Review of Biochemistry

Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin

(2010) Philip G. Wong et al.   CELL CYCLE

The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin

(2010) P. Muller et al.   GENES & DEVELOPMENT

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

(2010) K. Labib   GENES & DEVELOPMENT

Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins

(2010) JunGoo Jee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization and Structure Determination of the Cdt1 Binding Domain of Human Minichromosome Maintenance (Mcm) 6

(2010) Zhun Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

(2010) Gregory M. Alushin et al.   NATURE

Eukaryotic DNA replication origins: many choices for appropriate answers

(2010) Marcel Méchali   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 ‘gate’

(2010) Matthew L. Bochman et al.   NUCLEIC ACIDS RESEARCH

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Loss of DNA Replication Control Is a Potent Inducer of Gene Amplification

(2010) B. M. Green et al.   SCIENCE

Diversity of Eukaryotic DNA Replication Origins Revealed by Genome-Wide Analysis of Chromatin Structure

(2010) Nicolas M. Berbenetz et al.   PLoS Genetics

DNA replication licensing control and rereplication prevention

(2010) Chonghua Li et al.   Protein & Cell

Protein Architecture of the Human Kinetochore Microtubule Attachment Site

(2009) Xiaohu Wan et al.   CELL

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

Endoreplication: polyploidy with purpose

(2009) H. O. Lee et al.   GENES & DEVELOPMENT

Acetylation/Deacetylation Modulates the Stability of DNA Replication Licensing Factor Cdt1

(2009) Michele A. Glozak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail

(2009) Nehmé Saksouk et al.   MOLECULAR CELL

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

(2009) V. De Marco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factors

(2009) Bulat I. Khayrutdinov et al.   PROTEIN SCIENCE

Orc1 Controls Centriole and Centrosome Copy Number in Human Cells

(2009) A. S. Hemerly et al.   SCIENCE

Cdt1 and Geminin in cancer: markers or triggers of malignant transformation?

(2008) Chariklia Petropoulou   Frontiers in Bioscience-Landmark

HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1

(2008) B. Miotto et al.   GENES & DEVELOPMENT

Linkage between Phosphorylation of the Origin Recognition Complex and Its ATP Binding Activity inSaccharomyces cerevisiae

(2008) Masaki Makise et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage

(2008) Jonathan R. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture and Flexibility of the Yeast Ndc80 Kinetochore Complex

(2008) Hong-Wei Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast

(2008) Y. Zou et al.   NUCLEIC ACIDS RESEARCH

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

(2008) Arkaitz Ibarra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA