Anti-Neuroinflammatory Property of Phlorotannins from Ecklonia cava on Aβ25-35-Induced Damage in PC12 Cells

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease

(2018) Bushra Shal et al.   Frontiers in Pharmacology

Orally Administered Phlorotannins from Eisenia arborea Suppress Chemical Mediator Release and Cyclooxygenase-2 Signaling to Alleviate Mouse Ear Swelling

(2018) Yoshimasa Sugiura et al.   Marine Drugs

Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease

(2018) Luca Piemontese et al.   MOLECULES

Flavonoids of Kudzu Root Fermented by Eurtotium cristatum Protected Rat Pheochromocytoma Line 12 (PC12) Cells against H2O2-Induced Apoptosis

(2017) Bo Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Mechanisms of Action of Curcumin in Alzheimer’s Disease

(2017) Mengxi Tang et al.   JOURNAL OF ALZHEIMERS DISEASE

Kinetics and Molecular Docking Studies of 6-Formyl Umbelliferone Isolated from Angelica decursiva as an Inhibitor of Cholinesterase and BACE1

(2017) Md Ali et al.   MOLECULES

Antioxidant properties of phlorotannins from brown seaweed Cystoseira trinodis (Forsskål) C. Agardh

(2017) R. Sathya et al.   Arabian Journal of Chemistry

The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer’s disease: an overview of pre-clinical studies and translational perspectives in clinical practice

(2017) Marco Cascella et al.   Infectious Agents and Cancer

Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease

(2017) Charlene Supnet et al.   JOURNAL OF ALZHEIMERS DISEASE

Anthoxanthin Polyphenols Attenuate AβOligomer-induced Neuronal Responses Associated with Alzheimer's Disease

(2016) Kayla M. Pate et al.   CNS Neuroscience & Therapeutics

Protective Effect of Brown Alga Phlorotannins against Hyper-inflammatory Responses in Lipopolysaccharide-Induced Sepsis Models

(2016) Yeong-In Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cholinesterase inhibitor (Altenuene) from an endophytic fungusAlternaria alternata: optimization, purification and characterization

(2016) J. Bhagat et al.   JOURNAL OF APPLIED MICROBIOLOGY

Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors

(2015) Jong Hwan Kwak et al.   BIOMATERIALS

Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes

(2015) Na-Jin Kang et al.   Biomolecules & Therapeutics

Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways

(2015) Yanji Cui et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Dieckol, a major phlorotannin inEcklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell-cycle arrest and AMPKα activation

(2015) Hyeon-Son Choi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Advances in algal drug research with emphasis on enzyme inhibitors

(2014) Kannan R.R. Rengasamy et al.   BIOTECHNOLOGY ADVANCES

8,8′-Bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of NF-κB signaling and ROS production in LPS-stimulated macrophages

(2014) Yeong-In Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

p-Coumaric Acid and Ursolic Acid from Corni fructus Attenuated β-Amyloid25–35-Induced Toxicity through Regulation of the NF-κB Signaling Pathway in PC12 Cells

(2014) Jeong-Hyun Yoon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth

(2014) Ji-Hye Ahn et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

β-amyloid Peptides and Amyloid Plaques in Alzheimer’s Disease

(2014) Gunnar K. Gouras et al.   Neurotherapeutics

Neuroprotective effects of resveratrol in Alzheimer disease pathology

(2014) Shraddha D. Rege et al.   Frontiers in Aging Neuroscience

Polyphenol-rich fraction from Ecklonia cava (a brown alga) processing by-product reduces LPS-induced inflammation in vitro and in vivo in a zebrafish model

(2014) Seo-Young Kim et al.   ALGAE

Cytoprotective effect of dieckol on human endothelial progenitor cells (hEPCs) from oxidative stress-induced apoptosis

(2013) S. H. Lee et al.   FREE RADICAL RESEARCH

Preparation and Chromatographic Analysis of Phlorotannins

(2013) José Hipólito Isaza Martínez et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Undifferentiated and Differentiated PC12 Cells Protected by Huprines Against Injury Induced by Hydrogen Peroxide

(2013) Marta Pera et al.   PLoS One

Neuroprotective Effect of Phlorotannin Isolated from Ishige okamurae Against H2O2-Induced Oxidative Stress in Murine Hippocampal Neuronal Cells, HT22

(2012) Soo-Jin Heo et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells

(2012) Sung-Myung Kang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity

(2012) Il-Jun Kang et al.   NEUROTOXICOLOGY

Neuroprotective properties of resveratrol and derivatives

(2011) Tristan Richard et al.   Annals of the New York Academy of Sciences

Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death

(2011) Il-Jun Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

A Peptide That Binds Specifically to the β-Amyloid of Alzheimer's Disease: Selection and Assessment of Anti-β-Amyloid Neurotoxic Effects

(2011) Fang Wang et al.   PLoS One

Protective effect of diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF-α expression

(2011) Sanjay L. Dholakiya et al.   TOXICOLOGY IN VITRO

Phlorotannins from Ecklonia cava (Phaeophyceae): Biological activities and potential health benefits

(2010) Isuru Wijesekara et al.   BIOFACTORS

Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity

(2010) Hyun Ah Jung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ethanol and PTZ effects on siRNA-mediated GABAB1receptor: Down regulation of intracellular signaling pathway in prenatal rat cortical and hippocampal neurons

(2009) M.I. Naseer et al.   SYNAPSE

Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-κB pathways

(2008) Won-Kyo Jung et al.   FOOD AND CHEMICAL TOXICOLOGY

Immunomodulatory Effects of an Enzymatic Extract from Ecklonia cava on Murine Splenocytes

(2008) Ginnae Ahn et al.   MARINE BIOTECHNOLOGY

Effects of Ecklonia cava ethanolic extracts on airway hyperresponsiveness and inflammation in a murine asthma model: Role of suppressor of cytokine signaling

(2007) Se-Kwon Kim et al.   BIOMEDICINE & PHARMACOTHERAPY