Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1’(R), 6’(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax

Cytostatic hydroxycoumarin OT52 induces ER/Golgi stress and STAT3 inhibition triggering non-canonical cell death and synergy with BH3 mimetics in lung cancer

(2018) Jin-Young Lee et al.   CANCER LETTERS

Advances in treatment formulations for acute myeloid leukemia

(2018) Thomas Briot et al.   DRUG DISCOVERY TODAY

The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition

(2018) Michael Schnekenburger et al.   MOLECULES

Heteronemin, a marine natural product, sensitizes acute myeloid leukemia cells towards cytarabine chemotherapy by regulating farnesylation of Ras

(2018) Minakshi Saikia et al.   Oncotarget

Venetoclax for the treatment of chronic lymphocytic leukemia

(2017) Massimo Gentile et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges

(2017) Karen J. Nicacio et al.   JOURNAL OF NATURAL PRODUCTS

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

(2017) T-C Teh et al.   LEUKEMIA

Rational combination strategies to enhance venetoclax activity and overcome resistance in hematologic malignancies

(2017) Steven Grant   LEUKEMIA & LYMPHOMA

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

The Natural Antiangiogenic Compound AD0157 Induces Caspase-Dependent Apoptosis in Human Myeloid Leukemia Cells

(2017) Melissa García-Caballero et al.   Frontiers in Pharmacology

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise

(2016) Kristopher A. Sarosiek et al.   FEBS Journal

Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia

(2016) C Cerella et al.   LEUKEMIA

ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies

(2016) Jo Ishizawa et al.   Science Signaling

Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

(2016) Cristina Florean et al.   Oncotarget

ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies

(2016) Jo Ishizawa et al.   Science Signaling

Effects of Natural Products on Mcl-1 Expression and Function

(2015) Florian Muller et al.   CURRENT MEDICINAL CHEMISTRY

Oximoaspergillimide, a Fungal Derivative from a Marine Isolate ofAspergillussp.

(2015) Faviola Cardoso-Martínez et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Crystal Structure of Human DNA Methyltransferase 1

(2015) Zhi-Min Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

(2015) Guy J. Leclerc et al.   LEUKEMIA RESEARCH

Epipolythiodiketopiperazines from the Marine Derived Fungus Dichotomomyces cejpii with NF-κB Inhibitory Potential

(2015) Henrik Harms et al.   Marine Drugs

Tanzawaic acids isolated from a marine-derived fungus of the genus Penicillium with cytotoxic activities

(2015) Faviola Cardoso-Martínez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450

(2015) C Cerella et al.   Cell Death & Disease

Epigenetic modulators from “The Big Blue”: A treasure to fight against cancer

(2014) Michael Schnekenburger et al.   CANCER LETTERS

Recent Advances in Computer-Aided Drug Design as Applied to Anti-Influenza Drug Discovery

(2014) Prema Mallipeddi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

An Increase in Reactive Oxygen Species by Deregulation of ARNT Enhances Chemotherapeutic Drug-Induced Cancer Cell Death

(2014) Jiunn-Min Shieh et al.   PLoS One

Decitabine Rescues Cisplatin Resistance in Head and Neck Squamous Cell Carcinoma

(2014) Chi T. Viet et al.   PLoS One

5-aza-2′-deoxycytidine-mediated c-myc Down-regulation Triggers Telomere-dependent Senescence by Regulating Human Telomerase Reverse Transcriptase in Chronic Myeloid Leukemia

(2014) Cindy Grandjenette et al.   NEOPLASIA

In vitro characterisation of the anti-intravasative properties of the marine product heteronemin

(2013) Sabine Kopf et al.   ARCHIVES OF TOXICOLOGY

ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection

(2013) Hannah K. Long et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases

(2013) Carole Seidel et al.   CANCER LETTERS

Cyclic versus Hemi-Bastadins. Pleiotropic Anti-Cancer Effects: from Apoptosis to Anti-Angiogenic and Anti-Migratory Effects

(2013) Véronique Mathieu et al.   MOLECULES

A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2011

(2013) Wamtinga Sawadogo et al.   MOLECULES

Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

(2013) R. Pan et al.   Cancer Discovery

Cytotoxic effects of Fisturalin-3 and 11-Deoxyfisturalin-3 on Jurkat and U937 cell lines

(2012) Michael Rodney Mijares et al.   BIOMEDICAL PAPERS-OLOMOUC

Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer

(2011) Marc Schumacher et al.   BIOTECHNOLOGY ADVANCES

Antiparasitic Bromotyrosine Derivatives from the Marine Sponge Verongula rigida

(2011) Elkin Galeano et al.   Marine Drugs

A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2010

(2011) Marc Schumacher et al.   MOLECULES

Marine natural products targeting phospholipases A2

(2010) Florence Folmer et al.   BIOCHEMICAL PHARMACOLOGY

Sustained exposure to the DNA demethylating agent, 2′-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

(2010) Michael Schnekenburger et al.   BIOCHEMICAL PHARMACOLOGY

Chemotherapeutic sensitization by endoplasmic reticulum stress: Increasing the efficacy of taxane against prostate cancer

(2010) Yue Wu et al.   CANCER BIOLOGY & THERAPY

Photosynthetic marine organisms as a source of anticancer compounds

(2010) F. Folmer et al.   PHYTOCHEMISTRY REVIEWS

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

(2010) J. Song et al.   SCIENCE

Heteronemin, a spongean sesterterpene, inhibits TNFα-induced NF-κB activation through proteasome inhibition and induces apoptotic cell death

(2009) Marc Schumacher et al.   BIOCHEMICAL PHARMACOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Bioactive Diterpene Derivatives from the Marine SpongeSpongionellasp.

(2009) Mostafa E. Rateb et al.   JOURNAL OF NATURAL PRODUCTS

CXXC Domain of Human DNMT1 Is Essential for Enzymatic Activity

(2008) Mihika Pradhan et al.   BIOCHEMISTRY

Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis

(2008) M. Kraus et al.   MOLECULAR CANCER THERAPEUTICS

FireDock: a web server for fast interaction refinement in molecular docking

(2008) E. Mashiach et al.   NUCLEIC ACIDS RESEARCH

Marine natural products as targeted modulators of the transcription factor NF-κB

(2007) Florence Folmer et al.   BIOCHEMICAL PHARMACOLOGY