Increased α2δ-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain

α2δ-1 Is Essential for Sympathetic Output and NMDA Receptor Activity Potentiated by Angiotensin II in the Hypothalamus

(2018) Huijie Ma (马会杰) et al.   JOURNAL OF NEUROSCIENCE

The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions

(2018) Jinjun Chen et al.   Cell Reports

Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons

(2018) Li Wang et al.   JOURNAL OF NEUROCHEMISTRY

Focal Cerebral Ischemia and Reperfusion Induce Brain Injury Through α2δ-1–Bound NMDA Receptors

(2018) Yi Luo et al.   STROKE

Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord

(2017) Jing-Dun Xie et al.   NEUROPHARMACOLOGY

Alpha2delta-1 in SF1 + Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis

(2017) Jennifer A. Felsted et al.   Cell Reports

PresynapticN-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain

(2016) Jing-Dun Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity

(2016) Marie-Philippe Tétreault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain

(2016) Lingyong Li et al.   Cell Reports

Thrombospondin-4 reduces binding affinity of [3H]-gabapentin to calcium-channel α2δ-1-subunit but does not interact with α2δ-1 on the cell-surface when co-expressed

(2016) Beatrice Lana et al.   Scientific Reports

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition

(2015) Geoffroy Laumet et al.   NATURE NEUROSCIENCE

Increased Spinal Cord Na+-K+-2Cl−Cotransporter-1 (NKCC1) Activity Contributes to Impairment of Synaptic Inhibition in Paclitaxel-induced Neuropathic Pain

(2014) Shao-Rui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain

(2014) Marco Sisignano et al.   Nature Reviews Neurology

Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP

(2014) Hyungju Park et al.   NEURON

 2 -1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage

(2013) R. Patel et al.   JOURNAL OF NEUROSCIENCE

Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords

(2013) Shao-Rui Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

The α2δ subunits of voltage-gated calcium channels

(2012) Annette C. Dolphin   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Chronic Opioid Potentiates Presynaptic but Impairs PostsynapticN-Methyl-d-aspartic Acid Receptor Activity in Spinal Cords

(2012) Yi-Lin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Methyl-d-aspartate Receptor- and Calpain-mediated Proteolytic Cleavage of K+-Cl−Cotransporter-2 Impairs Spinal Chloride Homeostasis in Neuropathic Pain

(2012) Hong-Yi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α2δ expression sets presynaptic calcium channel abundance and release probability

(2012) Michael B. Hoppa et al.   NATURE

Pregabalin is a potent and selective ligand for α2δ-1 and α2δ-2 calcium channel subunits

(2011) Zheng Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protein Kinase CK2 Increases Glutamatergic Input in the Hypothalamus and Sympathetic Vasomotor Tone in Hypertension

(2011) Z.-Y. Ye et al.   JOURNAL OF NEUROSCIENCE

Opioid-Induced Long-Term Potentiation in the Spinal Cord Is a Presynaptic Event

(2010) H.-Y. Zhou et al.   JOURNAL OF NEUROSCIENCE

Presynaptic NMDARs in the Hippocampus Facilitate Transmitter Release at Theta Frequency

(2010) Lindsay McGuinness et al.   NEURON

Selective knockdown of NMDA receptors in primary afferent neurons decreases pain during phase 2 of the formalin test

(2010) J.A. McRoberts et al.   NEUROSCIENCE

Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain

(2010) C. S. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted disruption of the voltage-dependent calcium channel α2/δ-1-subunit

(2009) Geraldine A. Fuller-Bicer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanical Allodynia Induced by Paclitaxel, Oxaliplatin and Vincristine: Different Effectiveness of Gabapentin and Different Expression of Voltage-Dependent Calcium Channel α2δ-1 Subunit

(2009) Punam Gauchan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

(2009) Çagla Eroglu et al.   CELL

Sustained Inhibition of Neurotransmitter Release from Nontransient Receptor Potential Vanilloid Type 1-Expressing Primary Afferents by  -Opioid Receptor Activation-Enkephalin in the Spinal Cord

(2008) H.-Y. Zhou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Immunostaining of rat brain, spinal cord, sensory neurons and skeletal muscle for calcium channel alpha2-delta (α2-δ) type 1 protein

(2008) C.P. Taylor et al.   NEUROSCIENCE

Gabapentin Monotherapy for the Treatment of Chemotherapy-Induced Neuropathic Pain: A Pilot Study

(2008) Nicolas Tsavaris et al.   PAIN MEDICINE