The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma
出版年份 2018 全文链接
标题
The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma
作者
关键词
Mesothelioma, Focal adhesion kinase, Tyrosine kinase inhibitor, Angiogenesis, Spheroid formation, Orthotopic xenograft
出版物
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2018-12-12
DOI
10.1007/s00109-018-1725-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma
- (2018) Rajani Kanteti et al. CANCER BIOLOGY & THERAPY
- Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning
- (2018) Sigrid A. Langhans Frontiers in Pharmacology
- Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
- (2018) Ulrich A. Hirt et al. Oncogenesis
- A review of bevacizumab in the treatment of malignant pleural mesothelioma
- (2017) Solenn Brosseau et al. Future Oncology
- E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in Merlin-negative malignant mesothelioma cells
- (2017) T Kato et al. ONCOGENE
- IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks
- (2017) Bryan Serrels et al. Science Signaling
- Focal adhesion kinases crucially regulate TGFβ-induced migration and invasion of bladder cancer cells via Src kinase and E-cadherin
- (2017) De-Bo Kong et al. OncoTargets and Therapy
- IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks
- (2017) Bryan Serrels et al. Science Signaling
- Stem Cell Factor-Based Identification and Functional Properties of In Vitro-Selected Subpopulations of Malignant Mesothelioma Cells
- (2017) Walter Blum et al. Stem Cell Reports
- A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors
- (2016) J. C. Soria et al. ANNALS OF ONCOLOGY
- A first-in-Asian phase 1 study to evaluate safety, pharmacokinetics and clinical activity of VS-6063, a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced solid tumors
- (2016) Toshio Shimizu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Molecular Pathways: Endothelial Cell FAK--A Target for Cancer Treatment
- (2016) M. Roy-Luzarraga et al. CLINICAL CANCER RESEARCH
- FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal
- (2016) Monika Haemmerle et al. JOURNAL OF CLINICAL INVESTIGATION
- Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial
- (2016) Gérard Zalcman et al. LANCET
- Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
- (2016) Hong Jiang et al. NATURE MEDICINE
- Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: a multicenter study
- (2015) B Ghanim et al. BRITISH JOURNAL OF CANCER
- Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors
- (2015) Ingrid Moen et al. CLINICAL & EXPERIMENTAL METASTASIS
- Epigenetic down-regulation of integrin α7 increases migratory potential and confers poor prognosis in malignant pleural mesothelioma
- (2015) Viktoria Laszlo et al. JOURNAL OF PATHOLOGY
- FAK signaling in human cancer as a target for therapeutics
- (2015) Brian Y. Lee et al. PHARMACOLOGY & THERAPEUTICS
- Characterisation of Mesothelioma-Initiating Cells and Their Susceptibility to Anti-Cancer Agents
- (2015) Elham Alizadeh Pasdar et al. PLoS One
- Fibroblast Growth Factor Receptor Inhibition Is Active against Mesothelioma and Synergizes with Radio- and Chemotherapy
- (2014) Karin Schelch et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Inhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activities
- (2014) Pascal Dao et al. CANCER LETTERS
- Focal adhesion kinase inhibitors in the treatment of metastatic cancer: a patent review
- (2014) Ekambaram Shanthi et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer
- (2014) Nina R. Shah et al. GYNECOLOGIC ONCOLOGY
- Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship
- (2014) I. M. Shapiro et al. Science Translational Medicine
- Cell migration or cytokinesis and proliferation? – Revisiting the “go or grow” hypothesis in cancer cells in vitro
- (2013) Tamás Garay et al. EXPERIMENTAL CELL RESEARCH
- Role of Focal Adhesion Kinase in Regulating YB–1–Mediated Paclitaxel Resistance in Ovarian Cancer
- (2013) Yu Kang et al. JNCI-Journal of the National Cancer Institute
- Differential Expression of Extracellular Matrix Constituents and Cell Adhesion Molecules between Malignant Pleural Mesothelioma and Mesothelial Hyperplasia
- (2013) Greta Alì et al. Journal of Thoracic Oncology
- Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus
- (2012) Wei Li et al. EMBO REPORTS
- Abstract A249: BI 853520, a potent and highly selective inhibitor of protein tyrosine kinase 2 (focal adhesion kinase), shows efficacy in multiple xenograft models of human cancer.
- (2012) U. A. Hirt et al. MOLECULAR CANCER THERAPEUTICS
- Evolving Therapies and FAK Inhibitors for the Treatment of Cancer
- (2011) Kelli Bullard Dunn et al. Anti-Cancer Agents in Medicinal Chemistry
- PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments
- (2010) Isabelle Tanjoni et al. CANCER BIOLOGY & THERAPY
- Multicellular tumor spheroids: An underestimated tool is catching up again
- (2010) Franziska Hirschhaeuser et al. JOURNAL OF BIOTECHNOLOGY
- Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
- (2010) Carol Kilkenny et al. PLOS BIOLOGY
- Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells
- (2009) M. Luo et al. CANCER RESEARCH
- Malignant pleural mesothelioma cells resist anoikis as quiescent pluricellular aggregates
- (2009) J Daubriac et al. CELL DEATH AND DIFFERENTIATION
- A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth
- (2008) Vita M. Golubovskaya et al. JOURNAL OF MEDICINAL CHEMISTRY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now