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Cell Biology
Yu He, Xixi Wang, Weiliang Lu, Dan Zhang, Lan Huang, Yang Luo, Li Xiong, Haocheng Li, Peng Zhang, Qiu Li, Shufang Liang
Summary: This study comprehensively explores the molecular mechanisms of PGK1 in the progression and sorafenib resistance of KIRC. The upregulation of PGK1 is associated with poor prognosis in KIRC patients. Furthermore, PGK1 promotes tumor growth and sorafenib resistance in KIRC through regulating glycolysis and the CXCR4/ERK signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Teekaraman Dhanaraj, Manju Mohan, Jagadeesan Arunakaran
Summary: Research has shown that quercetin inhibits the survival and proliferation of human metastatic ovarian cancer cells by inactivating PI3K/Akt, Ras/Raf pathways, and EGFR expression. It also alters N-cadherin expression, decreases gelatinase secretion and MMP-2/-9 gene expression, and inhibits migration and adhesion of the cancer cells. These findings suggest that quercetin could be a valuable therapeutic drug for the treatment and prevention of metastatic ovarian cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Pharmacology & Pharmacy
Qian Zhang, Mengyun Shi, Ruiling Zheng, Haoyi Han, Xin Zhang, Feng Lin
Summary: This study demonstrates that C1632 can inhibit the proliferation and migration of ovarian cancer cells by concurrently inhibiting the LIN28B/let-7/FAK signaling pathway and FAK phosphorylation, and it also exhibits a significant inhibitory effect on ovarian cancer xenograft tumors in mice. Therefore, C1632 is a promising onco-therapeutic agent for the treatment of ovarian cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Sayantanee Biswas, Michelle R. Emond, Kurtis P. Chenoweth, James D. Jontes
Summary: The study found that lesions in delta-protocadherins increase cell divisions of neural progenitors in the hindbrain due to mis-regulation of the Wnt/beta-catenin signaling pathway. Additionally, delta-protocadherins can form a complex with the Wnt receptor Ryk, which is required for the increased proliferation in protocadherin mutants. This suggests that delta-protocadherins are novel regulators of Wnt/beta-catenin signaling in the development of neural circuits.
Article
Cell Biology
Zhiqin Fang, Yutong Wang, Bo Huang, Xiang Chen, Rundong Jiang, Mingzhu Yin
Summary: G9A, an important methyltransferase, is highly expressed in psoriasis. Inhibition of G9A can improve psoriatic dermatitis by regulating cell proliferation and apoptosis rather than inflammatory processes.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Xiaochen Li, Xiaopei Cao, Hanqiu Zhao, Mingzhou Guo, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Xiansheng Liu
Summary: Hypoxia activates the Notch4-ERK/JNK/P38 MAPK signaling pathway to promote the proliferation, migration, and anti-apoptotic effects of LUAD cells. Notch4 plays a key role in the growth and metastasis of LUAD. Inhibitors of ERK, JNK, and P38 can partially reverse the effects of Notch4.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ru Wang, Yuxing Wang, Xiaohe Liu, Menghao Liu, Lili Sun, Xiaohua Pan, Huili Hu, Baichun Jiang, Yongxin Zou, Qiao Liu, Yaoqin Gong, Molin Wang, Gongping Sun
Summary: Chemotherapy is commonly used to treat cancer, but acquired resistance and metastasis are major challenges. This study reveals that colorectal cancer cells can undergo anastasis after exposure to chemotherapy, leading to enhanced migration, metastasis, and chemoresistance. Mechanistically, chemotherapeutic drugs induce the upregulation of cIAP2 and activation of NFκB, which are crucial for cells to survive caspase activation and promote cancer progression.
CELL DEATH & DISEASE
(2023)
Article
Microbiology
Courtney M. Klappenbach, Nicholas M. Negretti, Jesse Aaron, Teng-Leong Chew, Michael E. Konkel
Summary: Our study reveals that C. jejuni infection alters the size and topology of focal adhesions in epithelial cells, leading to changes in cell adhesion strength and motility. The increased phosphorylation of paxillin and altered turnover at focal adhesions may contribute to the effects on cell behavior. Additionally, inhibiting protein synthesis or using specific mutants of C. jejuni can partially reverse these effects, suggesting a potential mechanism for the observed restricted intestinal repair in infected animals.
Article
Biochemistry & Molecular Biology
Yonglu Li, Xin Yu, Yaxuan Wang, Xiaodong Zheng, Qiang Chu
Summary: The study demonstrated that Tetrastigma hemsleyanum tuber flavonoids (THTF) could effectively suppress lung adenocarcinoma cell viability by inducing apoptosis through cytoskeleton collapse, mitochondrial dysfunction, and calcium overload. Proteomic analysis supported the in vitro findings, suggesting THTF and its major component kaempferol-3-O-rutinoside (K3R) as promising anti-cancer agents for lung cancer prevention and therapy.
Article
Cell Biology
Xinning Liu, Yanan Jiang, Hao Zhou, Xiaokun Zhao, Mingzhu Li, Zhuo Bao, Zitong Wang, Chenyang Zhang, Zhenliang Xie, Jimin Zhao, Zigang Dong, Kangdong Liu, Zhiping Guo
Summary: Esophageal squamous cell carcinoma (ESCC), a highly fatal upper gastrointestinal cancer, can be suppressed by dasabuvir, an FDA-approved drug for hepatitis C virus (HCV) treatment. Dasabuvir inhibits ESCC cell growth in a dose and time-dependent manner, arresting cell cycle progression. In vivo validation using patient-derived xenograft tumor models further confirmed the anti-tumor activity. Mechanistically, dasabuvir acts as a ROCK1 inhibitor, blocking the ROCK1/ERK signaling pathway and downregulating CDK4 and cyclin D1 expression.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Yun Liu, Jia Cao, Linqi Zhu, Wenjun Zhao, Yong Zhou, Chen Shao, Shihe Shao
Summary: circPGD promotes proliferation and migration of gastric cancer cells by interacting with miR-16-5p and ABL2, thereby modulating the SMAD2/3 and YAP signaling pathways.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Fu-Chun Huo, Zhi-Man Zhu, Wen-Tao Zhu, Qiu-Ying Du, Jia Liang, Jie Mou
Summary: The study demonstrates that high expression of SPHK2 in gastric cancer patients is associated with poor prognosis, and SPHK2 promotes proliferation, migration, and invasion of GC cells by inhibiting KLF2 expression, providing insights into the role of METTL3-mediated m(6)A modification of SPHK2 in GC progression and suggesting a potential therapeutic target for GC.
Article
Medicine, Research & Experimental
Jiali Shi, Shanshan Sun, Shuqiao Xing, Changgang Huang, Yuqian Huang, Qian Wang, Xiumin Xue, Zhichao Chen, Yongjie Wang, Zhihui Huang
Summary: Fraxinellone was found to inhibit the proliferation and growth of GBM cells in vitro, as well as suppress their migration and induce apoptosis. The mechanism of action involved the downregulation of SIRT3 signaling and the inhibition of GBM tumorigenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Ayon A. Hassan, Margarita Artemenko, Maggie K. S. Tang, Zeyu Shi, Lin-Yu Chen, Hung-Cheng Lai, Zhenyu Yang, Ho-Cheung Shum, Alice S. T. Wong
Summary: This study investigates the role of shear stress in ovarian cancer and the regulation of miR-199a-3p. The findings suggest that hepatocyte growth factor can downregulate miR-199a-3p expression, leading to increased cancer stemness and drug resistance. Additionally, low expression of miR-199a-3p is associated with enhanced drug resistance and poor prognosis in ovarian cancer patients. MiR-199a-3p mimics may serve as a novel targeted therapy for enhancing chemosensitivity.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Xitao Zhang, Tianlai Liu, Jinlin Huang, Jianping He
Summary: This study revealed that PICALM promotes CRC progression through the ERK/MAPK signaling pathway, highlighting its potential as a therapeutic target in clinical applications.
CANCER CELL INTERNATIONAL
(2022)