Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

(2018) Peng Zhao et al.   CELL

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism

(2017) Maroof Hasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles for motor neuron autophagy early and late in the SOD1G93Amouse model of ALS

(2017) Noam D. Rudnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression markers of Tumor Infiltrating Leukocytes

(2017) Patrick Danaher et al.   Journal for ImmunoTherapy of Cancer

Human TBK1: A Gatekeeper of Neuroinflammation

(2016) Liyana Ahmad et al.   TRENDS IN MOLECULAR MEDICINE

Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase

(2016) Eiichi Tokuda et al.   Acta Neuropathologica Communications

From animal models to human disease: a genetic approach for personalized medicine in ALS

(2016) Vincent Picher-Martel et al.   Acta Neuropathologica Communications

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

(2015) Cyril Pottier et al.   ACTA NEUROPATHOLOGICA

Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice

(2015) Maroof Hasan et al.   JOURNAL OF IMMUNOLOGY

TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes

(2015) Christine V. Möser et al.   Journal of Neuroinflammation

Serum microRNAs in sporadic amyotrophic lateral sclerosis

(2015) Axel Freischmidt et al.   NEUROBIOLOGY OF AGING

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis

(2015) Smitha Pillai et al.   Nature Communications

Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation

(2015) Jiayi Yu et al.   Nature Communications

A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis

(2015) Shannon M. Reilly et al.   Nature Communications

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

(2014) Melissa Nassif et al.   Autophagy

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

Specific Distribution of the Autophagic Protein GABARAPL1/GEC1 in the Developing and Adult Mouse Brain and Identification of Neuronal Populations Expressing GABARAPL1/GEC1

(2013) Jaclyn Nicole Le Grand et al.   PLoS One

Fumaric Acid Esters Stimulate Astrocytic VEGF Expression through HIF-1α and Nrf2

(2013) Diana Wiesner et al.   PLoS One

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling

(2012) Jin Jin et al.   NATURE IMMUNOLOGY

Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse model

(2011) Rengang Wang et al.   GLIA

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

(2011) Yi-Hung Ou et al.   MOLECULAR CELL

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

TBK1 Mediates Crosstalk Between the Innate Immune Response and Autophagy

(2011) H. Weidberg et al.   Science Signaling

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos

(2009) Stefan Wiese et al.   Nature Protocols

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE