Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation

Energy Metabolism of the Osteoblast: Implications for Osteoporosis

(2017) Wen-Chih Lee et al.   ENDOCRINE REVIEWS

Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome

(2017) Stefano Zanotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool

(2017) Rialnat A Lawal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton

(2016) Timur Yorgan et al.   BONE

Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle

(2016) Vera Slaninova et al.   Open Biology

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

(2015) Jianwen Wei et al.   CELL

Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption

(2015) Ernesto Canalis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTH Promotes Bone Anabolism by Stimulating Aerobic Glycolysis via IGF Signaling

(2015) Emel Esen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation

(2015) Jun Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast

(2015) Julie L. Frey et al.   MOLECULAR AND CELLULAR BIOLOGY

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

(2015) Peter C. Hart et al.   Nature Communications

Alteration of Mitochondrial Proteome Due to Activation of Notch1 Signaling Pathway

(2014) Nandini Pal Basak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB

(2014) Hengwei Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased glutamine catabolism mediates bone anabolism in response to WNT signaling

(2014) Courtney M. Karner et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

(2013) Emel Esen et al.   Cell Metabolism

Treatment Trends and Outcomes of Small-Cell Carcinoma of the Bladder: In Regard to Koay et al. (Int J Radiat Oncol Biol Phys 2011 Oct 20)

(2012) Nabil Ismaili   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

(2012) Xiaolin Tu et al.   PLoS Genetics

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

(2011) Bertrand Isidor et al.   NATURE GENETICS

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

(2011) Michael A Simpson et al.   NATURE GENETICS

Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms

(2011) S. K.- J. Landor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch2 Activation in the Embryonic Kidney Depletes Nephron Progenitors

(2010) S. Fujimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch Inhibits Osteoblast Differentiation and Causes Osteopenia

(2008) Stefano Zanotti et al.   ENDOCRINOLOGY

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

(2008) B. Clem et al.   MOLECULAR CANCER THERAPEUTICS

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE