Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation

Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness

(2018) Shan Wan et al.   HEPATOLOGY

Drosophila melanogasterGuk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large

(2018) Sofia Caria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cell fate determinant Scribble is required for maintenance of hematopoietic stem cell function

(2018) Juliane Mohr et al.   LEUKEMIA

Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture

(2018) Colin D. Donohoe et al.   PLoS Genetics

Proteome‐wide analysis of phospho‐regulated PDZ domain interactions

(2018) Gustav N Sundell et al.   Molecular Systems Biology

E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo

(2018) Xue Wang et al.   PLoS Genetics

An alternative mode of epithelial polarity in the Drosophila midgut

(2018) Jia Chen et al.   PLOS BIOLOGY

Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization

(2017) Fares Kharfallah et al.   HUMAN MOLECULAR GENETICS

The neuronal protein Neurexin directly interacts with the Scribble–Pix complex to stimulate F-actin assembly for synaptic vesicle clustering

(2017) Menglong Rui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX

(2017) Krystle Y. B. Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling

(2017) Hang Liu et al.   JOURNAL OF CELL BIOLOGY

Development and dynamics of cell polarity at a glance

(2017) Joseph P. Campanale et al.   JOURNAL OF CELL SCIENCE

The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition

(2017) Masatoshi Yamamoto et al.   NATURE

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation

(2017) Christina B. Wölwer et al.   PLoS One

From Planar Cell Polarity to Ciliogenesis and Back: The Curious Tale of the PPE and CPLANE proteins

(2017) Paul N. Adler et al.   TRENDS IN CELL BIOLOGY

Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway

(2017) Jie Liu et al.   Scientific Reports

Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse

(2016) Muna L Hilal et al.   CEREBRAL CORTEX

SnoN Antagonizes the Hippo Kinase Complex to Promote TAZ Signaling during Breast Carcinogenesis

(2016) Qingwei Zhu et al.   DEVELOPMENTAL CELL

Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia

(2016) John Vaughen et al.   DEVELOPMENTAL CELL

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib

(2016) Tianliang Sun et al.   JOURNAL OF CELL BIOLOGY

The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling

(2016) Janina Hendrick et al.   JOURNAL OF CELL SCIENCE

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

(2016) Weiyue Zheng et al.   NATURE CELL BIOLOGY

ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity

(2016) Baoen Chen et al.   Nature Chemical Biology

Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling

(2016) Jinwei Zhu et al.   NATURE REVIEWS NEUROSCIENCE

Scribble Scaffolds a Signalosome for Active Forgetting

(2016) Isaac Cervantes-Sandoval et al.   NEURON

A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons

(2016) Yu-Chih Lin et al.   Frontiers in Cellular Neuroscience

Scribbled Optimizes BMP Signaling through Its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis

(2016) Jinghua Gui et al.   PLoS Genetics

Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt)

(2015) Yingzi Yang et al.   Annual Review of Cell and Developmental Biology

Asymmetric cell division during T cell development controls downstream fate

(2015) Kim Pham et al.   JOURNAL OF CELL BIOLOGY

The Rho-specific GAP protein DLC3 coordinates endocytic membrane trafficking

(2015) A. C. Braun et al.   JOURNAL OF CELL SCIENCE

NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling

(2015) Leanne Clattenburg et al.   MOLECULAR AND CELLULAR BIOLOGY

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

(2015) Helen B. Pearson et al.   Molecular Cancer

Differential regulation of the Hippo pathway by adherens junctions and apical–basal cell polarity modules

(2015) Chih-Chao Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cadherins and catenins in dendrite and synapse morphogenesis

(2015) Eunju Seong et al.   Cell Adhesion & Migration

The Polarity Protein Scribble Regulates Myelination and Remyelination in the Central Nervous System

(2015) Andrew A. Jarjour et al.   PLOS BIOLOGY

Spectrin binding motifs regulate Scribble cortical dynamics and polarity function

(2015) Batiste Boëda et al.   eLife

The transcriptional response to tumorigenic polarity loss in Drosophila

(2015) Brandon D Bunker et al.   eLife

Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules

(2015) Nathan D Camp et al.   Cell Discovery

Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer

(2014) M. E. Feigin et al.   CANCER RESEARCH

The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization

(2014) Geert de Vreede et al.   DEVELOPMENT

The cell biology of planar cell polarity

(2014) Danelle Devenport   JOURNAL OF CELL BIOLOGY

A Structural Portrait of the PDZ Domain Family

(2014) Andreas Ernst et al.   JOURNAL OF MOLECULAR BIOLOGY

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

(2014) Y. Ivarsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scribble1/AP2 Complex Coordinates NMDA Receptor Endocytic Recycling

(2014) Nicolas H. Piguel et al.   Cell Reports

Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland

(2014) Nathan J. Godde et al.   PLoS Genetics

Discovery and Confirmation of Ligand Binding Specificities of the Schistosoma japonicum Polarity Protein Scribble

(2014) Pengfei Cai et al.   PLoS Neglected Tropical Diseases

The Polarity Protein Scrib Is Essential for Directed Endothelial Cell Migration

(2013) U. Ruth Michaelis et al.   CIRCULATION RESEARCH

Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse

(2013) Idella F. Yamben et al.   DEVELOPMENTAL BIOLOGY

Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation

(2013) I. A. Elsum et al.   JOURNAL OF CELL SCIENCE

Epithelial junctions maintain tissue architecture by directing planar spindle orientation

(2013) Yu-ichiro Nakajima et al.   NATURE

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

Shaping the nervous system: role of the core planar cell polarity genes

(2013) Fadel Tissir et al.   NATURE REVIEWS NEUROSCIENCE

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo

(2013) I A Elsum et al.   ONCOGENE

A Novel Interaction between hScrib and PP1γ Downregulates ERK Signaling and Suppresses Oncogene-Induced Cell Transformation

(2013) Kazunori Nagasaka et al.   PLoS One

Shaping up for action

(2013) Barry Denholm   Organogenesis

Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear

(2012) A. P. Giese et al.   DEVELOPMENT

Drosophila neuroblasts: a model for stem cell biology

(2012) C. C. F. Homem et al.   DEVELOPMENT

Scribble is required for normal epithelial cell–cell contacts and lumen morphogenesis in the mammalian lung

(2012) Laura L. Yates et al.   DEVELOPMENTAL BIOLOGY

Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1–HSP90

(2012) Dennis J. Eastburn et al.   JOURNAL OF CELL SCIENCE

Loss of Scribble causes cell competition in mammalian cells

(2012) M. Norman et al.   JOURNAL OF CELL SCIENCE

Role of the Polarity Protein Scribble for Podocyte Differentiation and Maintenance

(2012) Björn Hartleben et al.   PLoS One

Scribble Acts in the Drosophila Fat-Hippo Pathway to Regulate Warts Activity

(2012) Shilpi Verghese et al.   PLoS One

The Scribble Polarity Protein Stabilizes E-Cadherin/p120-Catenin Binding and Blocks Retrieval of E-Cadherin to the Golgi

(2012) Madhura Lohia et al.   PLoS One

The Hippo pathway and apico–basal cell polarity

(2011) Alice Genevet et al.   BIOCHEMICAL JOURNAL

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

(2011) Karen Doggett et al.   BMC DEVELOPMENTAL BIOLOGY

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration

(2011) G. S. Walsh et al.   DEVELOPMENT

Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila

(2011) Shizue Ohsawa et al.   DEVELOPMENTAL CELL

Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt

(2011) Xin Li et al.   EMBO REPORTS

Mutations in the planar cell polarity genesCELSR1andSCRIBare associated with the severe neural tube defect craniorachischisis

(2011) Alexis Robinson et al.   HUMAN MUTATION

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

(2011) Helen B. Pearson et al.   JOURNAL OF CLINICAL INVESTIGATION

 -Pix Modulates Actin-Mediated Recruitment of Synaptic Vesicles to Synapses

(2011) Y. Sun et al.   JOURNAL OF NEUROSCIENCE

Emerging Theme: Cellular PDZ Proteins as Common Targets of Pathogenic Viruses

(2011) R. T. Javier et al.   JOURNAL OF VIROLOGY

The multiple-specificity landscape of modular peptide recognition domains

(2011) D. Gfeller et al.   Molecular Systems Biology

Tumor suppression by cell competition through regulation of the Hippo pathway

(2011) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocytic Internalization Routes Required for Delta/Notch Signaling

(2010) Sarah L. Windler et al.   CURRENT BIOLOGY

Zebrafish Neural Tube Morphogenesis Requires Scribble-Dependent Oriented Cell Divisions

(2010) Mihaela Žigman et al.   CURRENT BIOLOGY

Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b

(2010) C. Wansleeben et al.   DEVELOPMENT

Phosphorylation state regulates the localization of Scribble at adherens junctions and its association with E-cadherin–catenin complexes

(2010) Ken Yoshihara et al.   EXPERIMENTAL CELL RESEARCH

NOS1AP Associates with Scribble and Regulates Dendritic Spine Development

(2010) L. Richier et al.   JOURNAL OF NEUROSCIENCE

The Planar Polarity Protein Scribble1 Is Essential for Neuronal Plasticity and Brain Function

(2010) M. M. Moreau et al.   JOURNAL OF NEUROSCIENCE

The ESEV PDZ-Binding Motif of the Avian Influenza A Virus NS1 Protein Protects Infected Cells from Apoptosis by Directly Targeting Scribble

(2010) H. Liu et al.   JOURNAL OF VIROLOGY

Interaction between Ras V12 and scribbled clones induces tumour growth and invasion

(2010) Ming Wu et al.   NATURE

The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

(2010) K Nagasaka et al.   ONCOGENE

Tumor Suppressor Scribble Regulates Assembly of Tight Junctions in the Intestinal Epithelium

(2009) Andrei I. Ivanov et al.   AMERICAN JOURNAL OF PATHOLOGY

The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors

(2009) Jean-Remy Courbard et al.   DEVELOPMENTAL BIOLOGY

Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling

(2009) Michael Hoffmann et al.   DEVELOPMENTAL BIOLOGY

Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila

(2009) Tatsushi Igaki et al.   DEVELOPMENTAL CELL

MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells

(2009) Camille Arnaud et al.   FEBS LETTERS

Crumbs stabilises epithelial polarity during tissue remodelling

(2009) K. Campbell et al.   JOURNAL OF CELL SCIENCE

Scribble Interacts with β-Catenin to Localize Synaptic Vesicles to Synapses

(2009) Yu Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Vimentin Regulates Scribble Activity by Protecting It from Proteasomal Degradation

(2009) Dominic C.Y. Phua et al.   MOLECULAR BIOLOGY OF THE CELL

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

(2009) K. Skouloudaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

(2008) Lixing Zhan et al.   CELL

Scrib regulates PAK activity during the cell migration process

(2008) Sébastien Nola et al.   HUMAN MOLECULAR GENETICS

Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing

(2008) C. A. Lockwood et al.   JOURNAL OF CELL SCIENCE

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

(2008) L E Dow et al.   ONCOGENE