Article
Pharmacology & Pharmacy
Yang Zhao, Zhao Ding, Wenhao Ge, Junhao Liu, Xi Xu, Rui Cheng, Jianfa Zhang
Summary: Riclinoctaose, an immunomodulatory octasaccharide, showed protective effects against renal ischemia-reperfusion injury in mice by inhibiting M1 macrophage polarization and promoting M2 macrophage recruitment. The therapeutic potential of Riclinoctaose in preventing renal ischemia-reperfusion injury was highlighted by its ability to modulate macrophage polarization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shuang-Quan Yu, Shuangtao Ma, Donna H. Wang
Summary: The degeneration of TRPV1-positive nerves exacerbates salt-induced hypertension and renal injury after I/R by enhancing renal macrophage infiltration. Depleting macrophages can abolish these effects.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Biotechnology & Applied Microbiology
Shengjie Tang, Xiangcheng Xie, Ming Wang, Lili Yang, Wei Wei
Summary: Asiaticoside has a protective effect on renal ischemia-reperfusion injury (IRI) by inhibiting inflammatory mediators and promoting macrophage polarization.
Article
Cell Biology
Zhaohui Liu, Yanli Meng, Yu Miao, Lili Yu, Qianjie Wei, Yuqing Li, Bing Zhang, Qiannan Yu
Summary: Propofol offers renoprotection against renal ischemia/reperfusion injury by stimulating PPAR gamma/STAT3-dependent macrophage conversion to the M2 phenotype.
Article
Physiology
Wararat Kittikulsuth, Daisuke Nakano, Kento Kitada, Norio Suzuki, Masayuki Yamamoto, Akira Nishiyama
Summary: This study reveals that NG2(+) cells in injured kidneys show macrophage-like activities, express anti-inflammatory cytokine genes, and play a crucial role in facilitating the recovery process after renal injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Immunology
Xiao Hu, Yanan Xu, Zhaoqi Zhang, Zuofu Tang, Jinhua Zhang, You Luo, Weiming Deng, Zhanwen Dong, Yong Zhao, Ning Na
Summary: The expression of TSC1 in macrophages plays an important role in the process of renal ischemia-reperfusion injury, acting as an inflammation suppressor during the early phase and a fibrosis promoter during the repair phase.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Zhizhi Hu, Juan Zhan, Guangchang Pei, Rui Zeng
Summary: Clodronate liposomes can alleviate renal fibrosis and tissue damage by inducing M1/M2 polarization and reducing the levels of inflammatory cytokines IL-10 and TGF-beta.
Article
Nutrition & Dietetics
Douglas Ikedo Machado, Eloiza de Oliveira Silva, Sara Ventura, Maria de Fatima Fernandes Vattimo
Summary: Chronic kidney disease (CKD) and acute kidney injury (AKI) are global health problems that affect over 850 million people. Diabetes mellitus (DM) increases the susceptibility to AKI. Curcumin has shown positive effects in diabetic rats with AKI, improving renal function and reducing oxidative stress.
Article
Pharmacology & Pharmacy
Lin Zhou, Shuhui Yang, Xiaoming Zou
Summary: This study found that farrerol (FA) has a protective effect against myocardial ischemia/reperfusion (I/R) injury by alleviating myocardial damage, reducing inflammation, and regulating oxidative stress. The study also revealed that FA inhibits NLRP3 inflammasome activation by interfering with NLRP3 and NEK7. These findings suggest the potential use of FA as an immunomodulator in clinical therapy for myocardial I/R, and support the targeted macrophage therapy for myocardial I/R.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Gaomin Huang, Qiu Yao, Zhenfeng Ye, Yawei Huang, Chiyu Zhang, Yi Jiang, Xiaoqing Xi
Summary: There are gender differences in renal ischemia-reperfusion injury, with male mice being more susceptible. Inhibiting AR expression or regulating miR-21 levels can promote the expression of PDCD4 and apoptosis protein caspase3, thereby exacerbating ischemia-reperfusion injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jamie Francisco, Dominic P. Del Re
Summary: Acute myocardial infarction (MI) is a condition that causes cardiac damage and cell loss. Restoring coronary flow is the standard treatment for MI, but reperfusion triggers inflammation and worsens heart injury. The immune response plays a crucial role in the pathogenesis and resolution of ischemia/reperfusion (I/R) injury, but our understanding is still incomplete.
Article
Multidisciplinary Sciences
Eva Vonbrunn, Tajana Ries, Stefan Soellner, Janina Mueller-Deile, Maike Buettner-Herold, Kerstin Amann, Christoph Daniel
Summary: This study discovered that in renal transplantation, the expression levels of multiple complement-related genes associated with rejection pathology were correlated with cold ischemia time and markers of inflammation. Multiplex mRNA analysis may be a valuable method for refining diagnosis and exploring new rejection pathways.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Jinyan Zhang, Liwei Liu, Zhen Dong, Xicun Lu, Wenxuan Hong, Jin Liu, Xiaoyi Zou, Jinfeng Gao, Hao Jiang, Xiaolei Sun, Kai Hu, Youjun Yang, Junbo Ge, Xiao Luo, Aijun Sun
Summary: This study utilizes a peroxynitrite-triggered carbon monoxide donor to generate a biomimetic carbon monoxide nanogenerator, which is coated with macrophage membrane for targeted delivery to the ischemic area and neutralization of proinflammatory cytokines, effectively improving myocardial ischemia-reperfusion injury. This research provides a new perspective on the safe therapeutic use of carbon monoxide for myocardial ischemia-reperfusion injury by utilizing a novel carbon monoxide donor combined with biomimetic technology. The M/PCOD@PLGA nanogenerator offers targeted delivery of carbon monoxide to the ischemic area, minimizing potential toxicity and enhancing therapeutic efficacy.
BIOACTIVE MATERIALS
(2023)
Article
Immunology
Jiong Zhang, Qing Li, Yu-Rong Zou, Shu-kun Wu, Xiang-heng Lu, Gui-sen Li, Jia Wang
Summary: The study revealed that the HMGB1-TLR4-IL-23-IL-17A axis plays a crucial role in renal ischemia-reperfusion injury by promoting neutrophil activation and regulating inflammation, oxidative stress, apoptosis, and kidney injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ling Gao, Fan Qiu, Hao Cao, Hao Li, Gonghua Dai, Teng Ma, Yanshan Gong, Wei Luo, Dongling Zhu, Zhixuan Qiu, Ping Zhu, Shuguang Chu, Huangtian Yang, Zhongmin Liu
Summary: This study found that altering the levels of a specific miRNA (miR-125a-5p) in the heart can replicate the cardioprotective effects of mesenchymal stem cells and their secreted exosomes, increasing cardiac function and limiting adverse remodeling. In addition, miR-125a-5p treatment can promote angiogenesis, inhibit fibroblast proliferation and activation, and change the function of macrophages and endothelial cells through regulation of specific genes.