期刊
HORMONE AND METABOLIC RESEARCH
卷 41, 期 2, 页码 159-163出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1119408
关键词
beta-cells; diabetes mellitus type 2; insulin secretion; Wnt
The Wnt-signalling pathway plays a well-established role in embryogenesis and tumourigenesis. However, recent data puts Wnt-signalling in the context of metabolic disease. In vitro and in vivo data characterised the role of Wnt-signalling molecules in the regulation of adipocyte differentiation (adipogenesis). Furthermore, Writs play a pivotal role in regulating pancreatic beta-cell function and mass. In addition, studies found polymorphisms within the gene encoding TCF7L2, a Wnt-regulated transcription factor, to contribute an increased risk to develop type 2 diabetes mellitus in humans. This review will summarise recent aspects of Wnt-signilling in these pathophysiologic events and discuss the contributions of dysregulation in Wnt-signalling to features of the metabolic syndrome.
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