标题
Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 5, Pages 1543
出版商
MDPI AG
发表日期
2018-05-23
DOI
10.3390/ijms19051543
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cell growth inhibition and apoptosis in breast cancer cells induced by anti-FZD7 scFvs: involvement of bioinformatics-based design of novel epitopes
- (2018) Neda Zarei et al. BREAST CANCER RESEARCH AND TREATMENT
- APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway
- (2018) Kenyi Saito-Diaz et al. DEVELOPMENTAL CELL
- Frizzled7 Promotes Epithelial-to-mesenchymal Transition and Stemness Via Activating Canonical Wnt/β-catenin Pathway in Gastric Cancer
- (2018) Guanman Li et al. International Journal of Biological Sciences
- A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells
- (2018) Aaron H. Nile et al. Nature Chemical Biology
- SOX8 regulates cancer stem-like properties and cisplatin-induced EMT in tongue squamous cell carcinoma by acting on the Wnt/β-catenin pathway
- (2017) S.-L. Xie et al. INTERNATIONAL JOURNAL OF CANCER
- Molecular genetics and targeted therapy of WNT-related human diseases (Review)
- (2017) Masuko Katoh et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Therapeutic Potential of Targeting Wnt/β-Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress
- (2017) Afsane Bahrami et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- MicroRNA-520b Suppresses Proliferation, Migration, and Invasion of Spinal Osteosarcoma Cells via Downregulation of Frizzled-8
- (2017) Jin Wang et al. ONCOLOGY RESEARCH
- Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding
- (2017) Aaron H. Nile et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Frizzled7 Antibody-Functionalized Nanoshells Enable Multivalent Binding for Wnt Signaling Inhibition in Triple Negative Breast Cancer Cells
- (2017) Rachel S. Riley et al. Small
- FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma
- (2017) Ting-Ting Cao et al. Oncotarget
- Involvement of c-Fos in cell proliferation, migration, and invasion in osteosarcoma cells accompanied by altered expression of Wnt2 and Fzd9
- (2017) Qiaozhen Wang et al. PLoS One
- Correction: FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells
- (2017) Shweta Tiwary et al. PLoS One
- miR-135b reverses chemoresistance of non-small cell lung cancer cells by downregulation of FZD1
- (2016) Wenmei Su et al. BIOMEDICINE & PHARMACOTHERAPY
- Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6 ) in breast cancer
- (2016) Gabriele Corda et al. JOURNAL OF PATHOLOGY
- Methylation status of the promoter region of the human frizzled 9 gene in acute myeloid leukemia
- (2016) Yingjie Zhang et al. Molecular Medicine Reports
- Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
- (2016) Zachary Steinhart et al. NATURE MEDICINE
- Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer
- (2016) Yiding Bian et al. ONCOLOGY REPORTS
- MicroRNA-27b suppresses Helicobacter pylori-induced gastric tumorigenesis through negatively regulating Frizzled7
- (2016) YAN GENG et al. ONCOLOGY REPORTS
- Long noncoding RNA AK126698 inhibits proliferation and migration of non-small cell lung cancer cells by targeting Frizzled-8 and suppressing Wnt/β-catenin signaling pathway
- (2016) Xiao Fu et al. OncoTargets and Therapy
- A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways
- (2016) Tianzhi Huang et al. Nature Communications
- Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways
- (2016) Karin Zins et al. Oncotarget
- Overexpression of FZD7 promotes glioma cell proliferation by upregulating TAZ
- (2016) Xia Qiu et al. Oncotarget
- Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling
- (2016) Carmen Oi-Ning Leung et al. Oncotarget
- Developing and characterization of single chain variable fragment (scFv) antibody against frizzled 7 (Fzd7) receptor
- (2016) Hamid Nickho et al. Bioengineered
- Suppression of multidrug resistance by rosiglitazone treatment in human ovarian cancer cells through downregulation of FZD1 and MDR1 genes
- (2015) Hui Zhang et al. ANTI-CANCER DRUGS
- FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer
- (2015) Bong-Kyu Kim et al. BMB Reports
- K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling
- (2015) Man-Tzu Wang et al. CELL
- WNT5A Has Anti-Prostate Cancer Effects In Vitro and Reduces Tumor Growth in the Skeleton In Vivo
- (2015) Stefanie Thiele et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development
- (2015) F. Morello et al. JOURNAL OF NEUROSCIENCE
- Down-regulation of Frizzled-7 expression inhibits migration, invasion, and epithelial–mesenchymal transition of cervical cancer cell lines
- (2015) Boya Deng et al. MEDICAL ONCOLOGY
- FZD2 inhibits the cell growth and migration of salivary adenoid cystic carcinomas
- (2015) LIN-CAN DING et al. ONCOLOGY REPORTS
- Frizzled2 mediates the migration and invasion of human oral squamous cell carcinoma cells through the regulation of the signal transducer and activator of transcription-3 signaling pathway
- (2015) ENJIAO ZHANG et al. ONCOLOGY REPORTS
- Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28
- (2015) Phuong N. Le et al. PHARMACOLOGY & THERAPEUTICS
- MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/β-catenin signaling pathway
- (2015) Qian Jiang et al. TUMOR BIOLOGY
- miR-124 represses FZD5 to attenuate P-glycoprotein-mediated chemo-resistance in renal cell carcinoma
- (2015) Qing-Zhi Long et al. TUMOR BIOLOGY
- MicroRNA-142-3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7
- (2015) Boya Deng et al. TUMOR BIOLOGY
- Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells
- (2015) Dustin J. Flanagan et al. Stem Cell Reports
- ARID3B Directly Regulates Ovarian Cancer Promoting Genes
- (2015) Alexander Bobbs et al. PLoS One
- SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier
- (2015) Sakura Tamaki et al. PLoS One
- Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.
- (2015) Sandra Cantilena et al. Oncotarget
- Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem-like Cells in Head and Neck Squamous Carcinomas
- (2014) S. Sun et al. CANCER RESEARCH
- A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis
- (2014) Taranjit S. Gujral et al. CELL
- ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling
- (2014) Rumela Chakrabarti et al. NATURE CELL BIOLOGY
- The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells
- (2014) A. Fernandez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape
- (2014) R. S. Kadzik et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung
- (2014) Rosaria Piga et al. TOXICOLOGY
- FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway
- (2014) M Asad et al. Cell Death & Disease
- BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10
- (2014) Chang Gong et al. Nature Communications
- Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer
- (2013) Dawn T Bravo et al. BMC CANCER
- WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3
- (2013) J P Dijksterhuis et al. BRITISH JOURNAL OF PHARMACOLOGY
- Tankyrases as drug targets
- (2013) Lari Lehtiö et al. FEBS Journal
- Wnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs
- (2013) Floriane Pez et al. JOURNAL OF HEPATOLOGY
- Frizzled6 Deficiency Disrupts the Differentiation Process of Nail Development
- (2013) Chang-Yi Cui et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Tumor-Initiating Cells and FZD8 Play a Major Role in Drug Resistance in Triple-Negative Breast Cancer
- (2013) S. Yin et al. MOLECULAR CANCER THERAPEUTICS
- Clinical Significance of Frizzled Homolog 3 Protein in Colorectal Cancer Patients
- (2013) Sze Chuen Cesar Wong et al. PLoS One
- Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons
- (2013) Zhong L Hua et al. eLife
- FZD1 Regulates Cumulus Expansion Genes and Is Required for Normal Female Fertility in Mice1
- (2012) Evelyne Lapointe et al. BIOLOGY OF REPRODUCTION
- Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway
- (2012) Hui Zhang et al. CANCER LETTERS
- Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
- (2012) A. Gurney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Frizzled-8 as a putative therapeutic target in human lung cancer
- (2011) Hua-qing Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation
- (2011) X. Jin et al. CANCER RESEARCH
- Frizzled7 as an emerging target for cancer therapy
- (2011) Taj D. King et al. CELLULAR SIGNALLING
- Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin
- (2011) Wei Wei et al. Molecular Cancer
- Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
- (2011) K. Ueno et al. MOLECULAR CANCER THERAPEUTICS
- Resistance or sensitivity of Wilms’ tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target
- (2011) N Pode-Shakked et al. ONCOGENE
- FZD7 has a critical role in cell proliferation in triple negative breast cancer
- (2011) L Yang et al. ONCOGENE
- FZD4 as a Mediator of ERG Oncogene-Induced WNT Signaling and Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells
- (2010) S. Gupta et al. CANCER RESEARCH
- Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma
- (2010) Sarah Beseme Nambotin et al. JOURNAL OF HEPATOLOGY
- International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors
- (2010) G. Schulte PHARMACOLOGICAL REVIEWS
- Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells
- (2009) K Ueno et al. BRITISH JOURNAL OF CANCER
- Inverse correlation of the up-regulation of FZD10 expression and the activation of β-catenin in synchronous colorectal tumors
- (2009) Satoshi Nagayama et al. CANCER SCIENCE
- Wnt-5a-induced Phosphorylation of DARPP-32 Inhibits Breast Cancer Cell Migration in a CREB-dependent Manner
- (2009) Christian Hansen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
- (2009) Baozhi Chen et al. Nature Chemical Biology
- Activation of the non-canonical Dvl–Rac1–JNK pathway by Frizzled homologue 10 in human synovial sarcoma
- (2009) C Fukukawa et al. ONCOGENE
- The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/β-catenin pathway
- (2009) M Flahaut et al. ONCOGENE
- Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10
- (2008) Chikako Fukukawa et al. CANCER SCIENCE
- Investigation of Frizzled-5 during embryonic neural development in mouse
- (2008) Carole J. Burns et al. DEVELOPMENTAL DYNAMICS
- Wnt-3a and Dickkopf-1 Stimulate Neurite Outgrowth in Ewing Tumor Cells via a Frizzled3- and c-Jun N-Terminal Kinase-Dependent Mechanism
- (2008) Y. Endo et al. MOLECULAR AND CELLULAR BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started