Combining Radiotherapy and Immunotherapy in Lung Cancer: Can We Expect Limitations Due to Altered Normal Tissue Toxicity?

Mechanisms of resistance to immune checkpoint inhibitors

(2018) Russell W Jenkins et al.   BRITISH JOURNAL OF CANCER

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cytosolic DNA Sensing in Organismal Tumor Control

(2018) Claire Vanpouille-Box et al.   CANCER CELL

Immunopharmacogenomics towards personalized cancer immunotherapy targeting neoantigens

(2018) Kazuma Kiyotani et al.   CANCER SCIENCE

The Integration of Radiotherapy With Immunotherapy for the Treatment of Non-Small Cell Lung Cancer

(2018) Eric C. Ko et al.   CLINICAL CANCER RESEARCH

Evaluation of normal lung tissue complication probability in gated and conventional radiotherapy using the 4D XCAT digital phantom

(2018) Sara Shahzadeh et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Immune Checkpoint Inhibitors and Cardiac Toxicity: An Emerging Issue

(2018) Gilda Varricchi et al.   CURRENT MEDICINAL CHEMISTRY

Targeting immune checkpoints in non small cell lung cancer

(2018) Andrea Bianco et al.   CURRENT OPINION IN PHARMACOLOGY

Immunotherapy and pulmonary toxicities: can concomitant immune-checkpoint inhibitors with radiotherapy increase the risk of radiation pneumonitis?

(2018) Guillaume Louvel et al.   EUROPEAN RESPIRATORY JOURNAL

Normal Tissue Complication Probability Modeling of Pulmonary Toxicity After Stereotactic and Hypofractionated Radiation Therapy for Central Lung Tumors

(2018) H. Tekatli et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Safety of combining radiotherapy with immune-checkpoint inhibition

(2018) William L. Hwang et al.   Nature Reviews Clinical Oncology

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

(2018) Matthew D. Hellmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bispecific antibodies for cancer therapy: A review

(2018) Anuradha Krishnamurthy et al.   PHARMACOLOGY & THERAPEUTICS

Normalgewebe: Strahlenempfindlichkeit, Toxizität, Konsequenzen für die Planung

(2018) A. Rühle et al.   RADIOLOGE

A targeted transforming growth factor-beta (TGF-β) blocker, TTB, inhibits tumor growth and metastasis

(2018) Changhua Zhou et al.   Oncotarget

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

(2018) Julie M. Diamond et al.   Cancer Immunology Research

Identifying and managing the adverse effects of immune checkpoint blockade

(2018) Arthur Winer et al.   Journal of Thoracic Disease

Combining immunotherapy and radiotherapy in lung cancer

(2018) Neeraj Bhalla et al.   Journal of Thoracic Disease

Immune checkpoint blockade for advanced non-small cell lung cancer: challenging clinical scenarios

(2018) Rebecca Tay et al.   Journal of Thoracic Disease

Next generation immune-checkpoints for cancer therapy

(2018) Chiara Donini et al.   Journal of Thoracic Disease

Targeting VEGF/VEGFR to Modulate Antitumor Immunity

(2018) Ju Yang et al.   Frontiers in Immunology

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

(2018) Judith A. Seidel et al.   Frontiers in Oncology

Combining radiation therapy and cancer immune therapies: From preclinical findings to clinical applications

(2018) S. Bockel et al.   Cancer Radiotherapie

Targeting the PD-1/PD-L1 axis for the treatment of non-small-cell lung cancer

(2018) D.E. Meyers et al.   Current Oncology

Immune-related adverse events from combination immunotherapy in cancer patients: A comprehensive meta-analysis of randomized controlled trials

(2018) Bo Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Radiation, inflammation and the immune response in cancer

(2018) Kelly J. McKelvey et al.   MAMMALIAN GENOME

The utility of quantitative CT radiomics features for improved prediction of radiation pneumonitis

(2018) Shane P. Krafft et al.   MEDICAL PHYSICS

Toxicité des inhibiteurs de points de contrôle immunitaires

(2018) M. Delaunay et al.   REVUE DES MALADIES RESPIRATOIRES

Strategies for Predicting Response to Checkpoint Inhibitors

(2018) Roberta Zappasodi et al.   Current Hematologic Malignancy Reports

Immune-Related Adverse Events in Cancer Patients Treated With Immune Checkpoint Inhibitors

(2018) Sabina Sandigursky et al.   Current Rheumatology Reports

Combining immunotherapy with radiation therapy in thoracic oncology

(2018) Shahed N. Badiyan et al.   Journal of Thoracic Disease

Not All Immune Checkpoints Are Created Equal

(2018) Annika De Sousa Linhares et al.   Frontiers in Immunology

The Tumor Vascular Endothelium as Decision Maker in Cancer Therapy

(2018) Diana Klein   Frontiers in Oncology

Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring in- and out-of-field

(2018) Mihaela Ghita et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Tumour cell-intrinsic CTLA4 regulates PD-L1 expression in non-small cell lung cancer

(2018) Huijun Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

(2018) Silvia C. Formenti et al.   NATURE MEDICINE

Comparison of predictive powers of functional and anatomic dosimetric parameters for radiation-induced lung toxicity in locally advanced non-small cell lung cancer

(2018) Linlin Xiao et al.   RADIOTHERAPY AND ONCOLOGY

Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again

(2018) Samantha L. Bucktrout et al.   Genome Medicine

Predicting Outcomes From Radical Radiotherapy for Non-small Cell Lung Cancer: A Systematic Review of the Existing Literature

(2018) Gerard M. Walls et al.   Frontiers in Oncology

Immune checkpoint inhibitor-associated interstitial lung diseases: some progress but still many issues

(2017) David Montani et al.   EUROPEAN RESPIRATORY JOURNAL

Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of prefibrotic macrophage clusters in irradiated lungs

(2017) Simone de Leve et al.   FASEB JOURNAL

Can radiotherapy potentiate the effectiveness of immune checkpoint inhibitors in lung cancer?

(2017) Monica Cheng et al.   Future Oncology

Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and preclinical experiences

(2017) Nikko Brix et al.   IMMUNOLOGICAL REVIEWS

Immunomodulation by ionizing radiation-impact for design of radio-immunotherapies and for treatment of inflammatory diseases

(2017) Benjamin Frey et al.   IMMUNOLOGICAL REVIEWS

Systemic effects of ionizing radiation at the proteome and metabolome levels in the blood of cancer patients treated with radiotherapy: the influence of inflammation and radiation toxicity

(2017) Karol Jelonek et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

National Cancer Database Analysis of Proton Versus Photon Radiation Therapy in Non-Small Cell Lung Cancer

(2017) Kristin A. Higgins et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Impact of Intensity-Modulated Radiation Therapy Technique for Locally Advanced Non–Small-Cell Lung Cancer: A Secondary Analysis of the NRG Oncology RTOG 0617 Randomized Clinical Trial

(2017) Stephen G. Chun et al.   JOURNAL OF CLINICAL ONCOLOGY

Outcomes targeting the PD-1/PD-L1 axis in conjunction with stereotactic radiation for patients with non-small cell lung cancer brain metastases

(2017) Kamran A. Ahmed et al.   JOURNAL OF NEURO-ONCOLOGY

Radiotherapy Rescue of a Nivolumab-Refractory Immune Response in a Patient with PD-L1–Negative Metastatic Squamous Cell Carcinoma of the Lung

(2017) Zhigang Yuan et al.   Journal of Thoracic Oncology

Abscopal Effect of Nivolumab in a Patient with Primary Lung Cancer

(2017) Tetsuya Komatsu et al.   Journal of Thoracic Oncology

Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial

(2017) Narek Shaverdian et al.   LANCET ONCOLOGY

Optimal management of EGFR -mutant non-small cell lung cancer with disease progression on first-line tyrosine kinase inhibitor therapy

(2017) Bin-Chi Liao et al.   LUNG CANCER

Cancer immunotherapy — immune checkpoint blockade and associated endocrinopathies

(2017) David J. Byun et al.   Nature Reviews Endocrinology

Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer

(2017) Scott J. Antonia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune‐Related Adverse Events as a Biomarker in Non‐Melanoma Patients Treated with Programmed Cell Death 1 Inhibitors

(2017) Julia Judd et al.   ONCOLOGIST

Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades

(2017) Florian Wirsdörfer et al.   Radiation Oncology

Emerging biomarkers for the combination of radiotherapy and immune checkpoint blockers

(2017) Claire Lhuillier et al.   SEMINARS IN CANCER BIOLOGY

Thoracic Radiation Normal Tissue Injury

(2017) Charles B. Simone   SEMINARS IN RADIATION ONCOLOGY

CAR T-cell therapy for lung cancer and malignant pleural mesothelioma

(2017) Masha Zeltsman et al.   Translational Research

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells

(2017) Nils-Petter Rudqvist et al.   Cancer Immunology Research

Immunological Aspect of Radiation-Induced Pneumonitis, Current Treatment Strategies, and Future Prospects

(2017) Anup Kainthola et al.   Frontiers in Immunology

Barriers to Radiation-Induced In Situ Tumor Vaccination

(2017) Erik Wennerberg et al.   Frontiers in Immunology

TREX1 dictates the immune fate of irradiated cancer cells

(2017) Claire Vanpouille-Box et al.   OncoImmunology

Radiotherapy Dosing for Locally Advanced Non-Small Cell Lung Carcinoma: “MTD” or “ALARA”?

(2017) Nitin Ohri   Frontiers in Oncology

Following the Preclinical Data: Leveraging the Abscopal Effect More Efficaciously

(2017) Wilfred Ngwa et al.   Frontiers in Oncology

CTLA-4 and PD-1 Pathways

(2016) Elizabeth I. Buchbinder et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Radiotherapy combination opportunities leveraging immunity for the next oncology practice

(2016) Fernanda G. Herrera et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis

(2016) F. Wirsdo rfer et al.   CANCER RESEARCH

The Emerging Role of B Cells in Tumor Immunity

(2016) Peiling Tsou et al.   CANCER RESEARCH

Stereotactic ablative radiotherapy for early stage non-small cell lung cancer: A critical literature review of predictive factors of relapse

(2016) Gokoulakrichenane Loganadane et al.   CANCER TREATMENT REVIEWS

Systematic review of case reports on the abscopal effect

(2016) Yazan Abuodeh et al.   CURRENT PROBLEMS IN CANCER

Immune-related adverse events with immune checkpoint blockade: a comprehensive review

(2016) J.M. Michot et al.   EUROPEAN JOURNAL OF CANCER

Current mechanism of acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors and updated therapy strategies in human nonsmall cell lung cancer

(2016) Kaixian Zhang et al.   Journal of Cancer Research and Therapeutics

Therapy-induced microenvironmental changes in cancer

(2016) Yuting Ma et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Damage-associated molecular patterns in cancer: a double-edged sword

(2016) C Hernandez et al.   ONCOGENE

A critical review of recent developments in radiotherapy for non-small cell lung cancer

(2016) Sarah Baker et al.   Radiation Oncology

Advances in personalized cancer immunotherapy

(2016) Kazuhiro Kakimi et al.   Breast Cancer

Key mechanisms involved in ionizing radiation-induced systemic effects. A current review

(2016) Ifigeneia V. Mavragani et al.   Toxicology Research

Mechanisms of immune evasion and current status of checkpoint inhibitors in non-small cell lung cancer

(2016) Angel Qin et al.   Cancer Medicine

The Role of Lymphocytes in Radiotherapy-Induced Adverse Late Effects in the Lung

(2016) Florian Wirsdörfer et al.   Frontiers in Immunology

Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?

(2016) Yu-Ling Li et al.   Cancer Biology & Medicine

Radiation Induced Lung Injury: Prediction, Assessment and Management

(2015) Prashanth Giridhar et al.   Asian Pacific Journal of Cancer Prevention

Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors

(2015) Anja Derer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The impact of radiation therapy on the antitumor immunity: Local effects and systemic consequences

(2015) Katalin Lumniczky et al.   CANCER LETTERS

Radiation takes its Toll

(2015) Josephine A. Ratikan et al.   CANCER LETTERS

Radiation triggering immune response and inflammation

(2015) Nezih Hekim et al.   CANCER LETTERS

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

(2015) Claire Vanpouille-Box et al.   CANCER RESEARCH

Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study

(2015) Jeffrey D Bradley et al.   LANCET ONCOLOGY

Opportunities and challenges of radiotherapy for treating cancer

(2015) Dörthe Schaue et al.   Nature Reviews Clinical Oncology

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

(2015) Dass S. Vinay et al.   SEMINARS IN CANCER BIOLOGY

The Next Hurdle in Cancer Immunotherapy: Overcoming the Non–T-Cell–Inflamed Tumor Microenvironment

(2015) Thomas F. Gajewski   SEMINARS IN ONCOLOGY

Radiation and Inflammation

(2015) Dörthe Schaue et al.   SEMINARS IN RADIATION ONCOLOGY

Balancing the innate immune system in tumor development

(2015) Catharina Hagerling et al.   TRENDS IN CELL BIOLOGY

EGFR Regulates the Development and Microarchitecture of Intratumoral Angiogenic Vasculature Capable of Sustaining Cancer Cell Intravasation

(2015) Petra Minder et al.   NEOPLASIA

Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy

(2015) Kristina Iribarren et al.   OncoImmunology

Antitumor activity and safety of combination therapy with the Toll-like receptor 9 agonist IMO-2055, erlotinib, and bevacizumab in advanced or metastatic non-small cell lung cancer patients who have progressed following chemotherapy

(2014) David A. Smith et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

No Clinically Significant Changes in Pulmonary Function Following Stereotactic Body Radiation Therapy for Early- Stage Peripheral Non-Small Cell Lung Cancer: An Analysis of RTOG 0236

(2014) Sinisa Stanic et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The systemic immune response to trauma: an overview of pathophysiology and treatment

(2014) Janet M Lord et al.   LANCET

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells

(2014) Florian Wirsdörfer et al.   Radiation Oncology

The Roles of CD73 in Cancer

(2014) Zhao-wei Gao et al.   Biomed Research International

Organizing Pneumonia as a Side Effect of Ipilimumab Treatment of Melanoma

(2013) Igor Z. Barjaktarevic et al.   CHEST

Ipilimumab associated hepatitis: imaging and clinicopathologic findings

(2013) Kyung Won Kim et al.   INVESTIGATIONAL NEW DRUGS

Adjuvant MAGE-A3 Immunotherapy in Resected Non–Small-Cell Lung Cancer: Phase II Randomized Study Results

(2013) Johan Vansteenkiste et al.   JOURNAL OF CLINICAL ONCOLOGY

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

(2013) Rikke B. Holmgaard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intensity modulated radiotherapy for stage III non-small cell lung cancer in the United States: Predictors of use and association with toxicities

(2013) Shervin M. Shirvani et al.   LUNG CANCER

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Development of radiation pneumopathy and generalised radiological changes after radiotherapy are independent negative prognostic factors for survival in non-small cell lung cancer patients

(2013) Katherina P. Farr et al.   RADIOTHERAPY AND ONCOLOGY

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

(2012) A. Facciabene et al.   CANCER RESEARCH

Autocrine VEGF–VEGFR2–Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

(2012) Petra Hamerlik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Radiotherapy Promotes Tumor-Specific Effector CD8+ T Cells via Dendritic Cell Activation

(2012) A. Gupta et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

The convergence of radiation and immunogenic cell death signaling pathways

(2012) Encouse B. Golden et al.   Frontiers in Oncology

CEACAM1 : modulateur central du métabolisme, de la progression tumorale,de l’angiogenèse et de l’immunité

(2011) Anne-Laure Nouvion et al.   M S-MEDECINE SCIENCES

Radiotherapy and "new" drugs-new side effects?

(2011) Maximilian Niyazi et al.   Radiation Oncology

Radiation Dose–Volume Effects in the Lung

(2010) Lawrence B. Marks et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Stereotactic Body Radiotherapy (SBRT) for Operable Stage I Non–Small-Cell Lung Cancer: Can SBRT Be Comparable to Surgery?

(2010) Hiroshi Onishi et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Stereotactic Body Radiation Therapy for Inoperable Early Stage Lung Cancer

(2010) Robert Timmerman   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Outcomes After Stereotactic Lung Radiotherapy or Wedge Resection for Stage I Non–Small-Cell Lung Cancer

(2010) Inga S. Grills et al.   JOURNAL OF CLINICAL ONCOLOGY

Meta-Analysis of Concomitant Versus Sequential Radiochemotherapy in Locally Advanced Non–Small-Cell Lung Cancer

(2010) Anne Aupérin et al.   JOURNAL OF CLINICAL ONCOLOGY

Adjuvant Therapy With Agonistic Antibodies to CD134 (OX40) Increases Local Control After Surgical or Radiation Therapy of Cancer in Mice

(2010) Michael J. Gough et al.   JOURNAL OF IMMUNOTHERAPY

Tumor Secretion of VEGF Induces Endothelial Cells to Suppress T cell Functions Through the Production of PGE2

(2010) Jennifer K. Mulligan et al.   JOURNAL OF IMMUNOTHERAPY

Stereotactic body radiation therapy versus surgical resection for stage I non–small cell lung cancer

(2010) Traves D. Crabtree et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

(2010) D. Citrin et al.   ONCOLOGIST

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

(2010) G.-O. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenetic mechanisms in radiation fibrosis

(2010) John Yarnold et al.   RADIOTHERAPY AND ONCOLOGY

Radiation Pulmonary Toxicity: From Mechanisms to Management

(2010) Paul R. Graves et al.   SEMINARS IN RADIATION ONCOLOGY

Systemic effects of local radiotherapy

(2009) Silvia C Formenti et al.   LANCET ONCOLOGY

Matrix Metalloproteinase-9 Is Required for Tumor Vasculogenesis but Not for Angiogenesis: Role of Bone Marrow-Derived Myelomonocytic Cells

(2008) G-One Ahn et al.   CANCER CELL

Cytotoxic T-Lymphocyte-Associated Antigen 4 Antibody-Induced Colitis and Its Management with Infliximab

(2008) R. L. Johnston et al.   DIGESTIVE DISEASES AND SCIENCES

Role of innate immune cells and their products in lung immunopathology

(2008) T SUZUKI et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY