期刊
ONCOIMMUNOLOGY
卷 6, 期 9, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2017.1339857
关键词
abscopal effect; cGAS; immune checkpoint blockers; nucleic acids sensing; radiotherapy; STING; type I interferon
资金
- NIH [R01 CA201246, S10 RR027619]
- Breast Cancer Research Foundation [BCRF-16-054]
- Chemotherapy Foundation
- DOD BCRP [W81XWH-13-1-0012]
- Anna-Maria and Stephen Kellen Foundation
The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA. TREX1 upregulation by radiation dose per fraction beyond a threshold of 10-12Gy results in poor synergy with immune checkpoint blockers.
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