Review
Pharmacology & Pharmacy
Pilar Abiega-Franyutti, Veronica Freyre-Fonseca
Summary: This study reveals a clear link between food additives and changes in the gut microbiota that lead to various chronic diseases, yet research on the effects of food additives on microbiota is still inadequate, indicating a need for further investigation in this area.
Review
Immunology
Yusuke Kinashi, Koji Hase
Summary: The intestinal surface is constantly exposed to various antigens, and intestinal epithelial cells play a crucial role in preventing the translocation of harmful antigens into the body. Disruption of the epithelial barrier can lead to increased intestinal permeability and leaky gut syndrome. The gut commensal microbiota is essential for regulating host immunity, and dysbiosis is associated with autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Angel Yun-Kuan Thye, Yi-Rou Bah, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Ya-Wen He, Sunny-Hei Wong, Sivakumar Thurairajasingam, Kok-Gan Chan, Learn-Han Lee, Vengadesh Letchumanan
Summary: Evidence suggests that the gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health, regulated through mechanisms such as inflammatory mediators and the immune system. Microbiota dysregulation has been observed in various inflammatory skin conditions, such as atopic dermatitis, rosacea, and psoriasis. Understanding the involvement of the gut microbiome in regulating skin health could lead to the development of novel therapies for these skin disorders, particularly psoriasis.
Review
Immunology
Marcela Mizuhira Gobbo, Marina Bocamino Bomfim, Wille Ygor Alves, Karen Cristina Oliveira, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: This review evaluates the effects of antibiotic therapy on gut microbiota and its impact on autoimmune diseases through preclinical studies. The findings suggest that antibiotic therapy can both improve and worsen autoimmune conditions, with the outcome being influenced by factors such as gender, IL-10, and Treg cells.
AUTOIMMUNITY REVIEWS
(2022)
Review
Immunology
Walaa K. Mousa, Fadia Chehadeh, Shannon Husband
Summary: The interaction between gut microbes and the immune system plays a crucial role in the development and treatment of systemic autoimmune diseases. Understanding how gut microbes can trigger or protect from these diseases can help us tackle them through dietary and lifestyle changes, microbiome-based therapies, identification of diagnostic biomarkers, and intervention with microbial population changes. Considering the microbiome signature as a key player in systemic autoimmune diseases holds promise in transforming these untreatable diseases into manageable or preventable ones.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Malin Holm Meyer-Myklestad, Asle Wilhelm Medhus, Kristina Berg Lorvik, Ingebjorg Seljeflot, Simen Hyll Hansen, Kristian Holm, Birgitte Stiksrud, Marius Troseid, Johannes Roksund Hov, Dag Kvale, Anne Margarita Dyrhol-Riise, Martin Kummen, Dag Henrik Reikvam
Summary: Restricted to the colon, enterocyte damage and mucosal immune dysfunction play a role for insufficient immune reconstitution in HIV infection independent of the gut microbiota.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Nutrition & Dietetics
Bianca Depieri Balmant, Danielle Cristina Fonseca, Ilanna Marques Rocha, Leticia Callado, Raquel Susana Matos de Miranda Torrinhas, Dan Linetzky Waitzberg
Summary: Practical and affordable tools to screen intestinal dysbiosis are necessary to support clinical decision making. This study aimed to design a new subjective screening tool, based on subjective and objective data, for the risk of intestinal dysbiosis. The new Dys-R questionnaire showed good performance in ruling out dysbiosis and identifying poor gut microbiota richness.
Review
Medicine, Research & Experimental
Xiaoyan Huang, Xiangyu Huang, Yi Huang, Jiarong Zheng, Ye Lu, Zizhao Mai, Xinyuan Zhao, Li Cui, Shaohong Huang
Summary: The human body is colonized by a diverse microbiome, including over 700 species of bacteria in the oral cavity. The balance between the oral microbiota and the immune system is crucial for maintaining a healthy state. Dysbiosis in the oral microbiome is involved in the development of autoimmune diseases through various mechanisms. Factors driving oral microbiota dysbiosis include genetics, diet, stress, smoking, antibiotics, tissue injury, and infection. Maintaining a balanced oral microbiome through good oral hygiene, diet, lifestyle, and microbial therapies may be beneficial in treating oral microbiota-mediated autoimmune diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Sisi Lin, Subhajit Mukherjee, Juanjuan Li, Weiliang Hou, Chao Pan, Jinyao Liu
Summary: The oral delivery of camouflaged probiotics can induce mucosal immune responses, regulate the gut microbiota, maintain gut homeostasis, and provide defense against external threats. Studies show that this approach effectively prevents intestinal barrier breakdown, bacterial translocation, and systemic inflammation.
Review
Medicine, Research & Experimental
Min'an Zhao, Jiayi Chu, Shiyao Feng, Chuanhao Guo, Baigong Xue, Kan He, Lisha Li
Summary: The gut microbiota plays a crucial role in maintaining host health by enhancing digestion, protecting the intestinal barrier, and interacting with the immune system. Dysbiosis of the gut microbiota, caused by various factors, is a major contributor to inflammatory diseases. The mechanisms underlying these diseases resulting from gut microbiota dysbiosis are not well categorized.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Lorenza Romani, Federica Del Chierico, Gabriele Macari, Stefania Pane, Maria Vittoria Ristori, Valerio Guarrasi, Simone Gardini, Giuseppe Rubens Pascucci, Nicola Cotugno, Carlo Federico Perno, Paolo Rossi, Alberto Villani, Stefania Bernardi, Andrea Campana, Paolo Palma, Lorenza Putignani
Summary: This study is the first to investigate the gut microbiota in children with COVID-19. The results showed that the gut microbiota of COVID-19 patients differs from that of healthy children and is associated with disease severity. The study also identified microbial markers that may be related to COVID-19. These findings are important for understanding the gut microbiota characteristics of pediatric COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Engineering, Environmental
Hua Zha, Jiawen Lv, Yiqing Lou, Wanlong Wo, Jiafeng Xia, Shengjie Li, Aoxiang Zhuge, Ruiqi Tang, Nian Si, Zhihao Hu, Haifeng Lu, Kevin Chang, Chenyu Wang, Guinian Si, Lanjuan Li
Summary: This study investigates the gut and oral microbiota alterations in individuals who frequently and occasionally consume food in disposable plastic containers and finds that reducing the size and amount of micro/nanoplastics cannot rectify the gut microbial dysbiosis caused by these containers.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Biology
Maria Jose Garcia-Bonete, Anandi Rajan, Francesco Suriano, Elena Layunta
Summary: The microbiota in the gastrointestinal tract is crucial for intestinal health and can regulate intestinal physiology. Disturbances in the microbiota, known as dysbiosis, can disrupt intestinal homeostasis and lead to disease development. This review aims to clarify the role of helminths, bacteriophages, fungi, and archaea in intestinal homeostasis and diseases, their interactions with bacteria, and their potential as therapeutic targets for intestinal disorders.
Article
Agriculture, Dairy & Animal Science
Javier Arenas-Montes, Pablo Perez-Martinez, Cristina Vals-Delgado, Juan Luis Romero-Cabrera, Magdalena P. Cardelo, Ana Leon-Acuna, Gracia M. Quintana-Navarro, Juan F. Alcala-Diaz, Jose Lopez-Miranda, Antonio Camargo, Francisco Perez-Jimenez
Summary: Pet ownership may reduce the risk of metabolic syndrome and obesity, with dog ownership showing more significant benefits. Having pets can alter the gut microbiota and contribute to the prevention of cardiometabolic diseases.
Review
Environmental Sciences
Laura Calero-Medina, Maria Jose Jimenez-Casquet, Leticia Heras-Gonzalez, Javier Conde-Pipo, Alejandro Lopez -Moro, Fatima Olea-Serrano, Miguel Mariscal-Arcas
Summary: Endocrine disrupting chemicals (EDCs) can interfere with hormonal actions and have been associated with a higher incidence of metabolic disorders. They affect numerous physiological, biochemical, and endocrinal activities, including reproduction, metabolism, immunity, and behavior. The purpose of this review was to elucidate the association of EDCs in food with the gut microbiota and with metabolic disorders. EDC exposure induces changes that can lead to microbial dysbiosis, and the microbial metabolites can affect the host metabolism.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Lucie Janeckova, Klara Kostovcikova, Jiri Svec, Monika Stastna, Hynek Strnad, Michal Kolar, Tomas Hudcovic, Jitka Stancikova, Jolana Tureckova, Nikol Baloghova, Eva Sloncova, Katerina Galuskova, Helena Tlaskalova-Hogenova, Vladimir Korinek
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Immunology
David P. Funda, Lenka Palova-Jelinkova, Jaroslav Golias, Zuzana Kroulikova, Alena Fajstova, Tomas Hudcovic, Radek Spisek
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Pharmacology & Pharmacy
Danica Michalickova, Tomas Hrncir, Nikolina Kutinova Canova, Ondrej Slanar
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Cell Biology
Alena Fajstova, Natalie Galanova, Stepan Coufal, Jana Malkova, Martin Kostovcik, Martina Cermakova, Helena Pelantova, Marek Kuzma, Blanka Sediva, Tomas Hudcovic, Tomas Hrncir, Helena Tlaskalova-Hogenova, Miloslav Kverka, Klara Kostovcikova
Article
Cell Biology
Otakar Dusek, Alena Fajstova, Aneta Klimova, Petra Svozilkova, Tomas Hrncir, Miloslav Kverka, Stepan Coufal, Johan Slemin, Helena Tlaskalova-Hogenova, John V. Forrester, Jarmila Heissigerova
Summary: The study showed that EcN can control inflammation and prevent EAU by regulating the immune response, suggesting that probiotics may play a role in regulating the gut-eye axis.
Review
Microbiology
Tomas Hrncir, Lucia Hrncirova, Miloslav Kverka, Robert Hromadka, Vladimira Machova, Eva Trckova, Klara Kostovcikova, Pavlina Kralickova, Jan Krejsek, Helena Tlaskalova-Hogenova
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, highly associated with metabolic syndrome. Dysbiosis of gut microbiota and disruption of intestinal permeability may play a role in its development. Therapeutic strategies include fecal microbiota transplantation, probiotics, prebiotics, and other approaches.
Article
Engineering, Biomedical
Danica Michalickova, Ivana Kramarikova, Hatice Kubra Ozturk, Tomas Kucera, Tomas Vacik, Tomas Hrncir, Nikolina Kutinova Canova, Martin Sima, Ondrej Slanar
Summary: This study investigates the involvement of the neuropeptide galanin in the pathophysiology of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis. The study examines the expression of galanin receptors (GalR1, GalR2, GalR3) in the spinal cords of EAE mice and identifies the cellular localization of GalR1 using qPCR analysis and immunohistochemistry. The results suggest that GalR1 may play a role in EAE, and further research is needed to fully understand its involvement.
BIOMEDICAL PAPERS-OLOMOUC
(2023)
Article
Physiology
Danica Michalickova, Hatice Kubra Ozturk, Jana Hroudova, Matej L'uptak, Tomas Kucera, Tomas Hrncir, Nikolina Kutinova Canova, Martin Sima, Ondrej Slanar
Summary: The aim of this study was to evaluate the therapeutic potential and mechanism of action of edaravone in a murine model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). The results showed that edaravone treatment ameliorated EAE severity, attenuated inflammation, decreased oxidative stress, increased the gene expression of Nrf2 and HO-1, increased the activity of the mitochondrial complex IV, and preserved ATP production in the spinal cords of EAE mice. These findings provide additional evidence of the potential of edaravone for the treatment of multiple sclerosis and expand our knowledge of its mechanism of action in the EAE model.
PHYSIOLOGICAL RESEARCH
(2022)
Editorial Material
Microbiology
Tomas Hrncir
Meeting Abstract
Immunology
A. F. Udoumoh, I. Benesova, Z. Jackova, T. Thon, M. Vavreckova, Z. Stehlikova, T. Hrncir, M. Kverka
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Jiraskova Z. Zakostelska, M. Kraus, S. Coufal, T. Thon, M. Mihula, Z. Reiss, T. Hrncir, P. Kleinova, Lizrova J. Preiningerova, V. Ticha, I. Kovarova, Kubala E. Havrdova, H. Tlaskalova-Hogenova, M. Kverka
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Allergy
H. Kozakova, M. Schwarzer, D. Srutkova, T. Hrncir, P. Hermanova, F. Leulier, I Schabussova
Meeting Abstract
Allergy
P. Hermanova, M. Schwarzer, D. Srutkova, T. Hudcovic, H. Kozakova, I Schabussova
Article
Immunology
Martin Schwarzer, Petra Hermanova, Dagmar Srutkova, Jaroslav Golias, Tomas Hudcovic, Christian Zwicker, Marek Sinkora, Johnnie Akguen, Ursula Wiedermann, Ludmila Tuckova, Hana Kozakova, Irma Schabussova
FRONTIERS IN IMMUNOLOGY
(2019)