The COX-2/prostanoid signaling cascades in seizure disorders

Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain

(2018) Amanda J. Morgan et al.   ACS Chemical Neuroscience

Discovery of novel Methylsulfonyl phenyl derivatives as potent human Cyclooxygenase-2 inhibitors with effective anticonvulsant action: Design, synthesis, in-silico, in-vitro and in-vivo evaluation

(2018) Chandra Bhushan Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy

(2018) Julia M. Post et al.   Frontiers in Molecular Neuroscience

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

(2017) Pavel Klein et al.   EPILEPSIA

Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet

(2017) Gaetano Terrone et al.   EPILEPSIA

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

(2017) Eleonora Aronica et al.   EPILEPSIA

EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis

(2017) Erin Greaves et al.   Scientific Reports

Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats

(2016) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Candidate Drug Targets for Prevention or Modification of Epilepsy

(2015) Nicholas H. Varvel et al.   Annual Review of Pharmacology and Toxicology

Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats

(2015) Rita Citraro et al.   BRAIN RESEARCH BULLETIN

Anticonvulsant activity of the cyclooxygenase-2 (COX-2) inhibitor etoricoxib in pentylenetetrazole-kindled rats is associated with memory impairment

(2015) Jatinder Katyal et al.   EPILEPSY & BEHAVIOR

A Large-Scale Study Indicates Increase in the Risk of Epilepsy in Patients With Different Risk Factors, Including Rheumatoid Arthritis

(2015) Kuang-Hsi Chang et al.   MEDICINE

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

(2015) Jianxiong Jiang et al.   NEUROBIOLOGY OF DISEASE

Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus

(2015) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Lead Optimization Studies of Cinnamic Amide EP2 Antagonists

(2014) Thota Ganesh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Central CRTH2, a Second Prostaglandin D2 Receptor, Mediates Emotional Impairment in the Lipopolysaccharide and Tumor-Induced Sickness Behavior Model

(2014) R. Haba et al.   JOURNAL OF NEUROSCIENCE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

(2014) Asheebo Rojas et al.   NEUROBIOLOGY OF DISEASE

COX-2-derived endocannabinoid metabolites as novel inflammatory mediators

(2014) Mireille Alhouayek et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cyclooxygenase-2 in epilepsy

(2013) Asheebo Rojas et al.   EPILEPSIA

Prostaglandin D2 is crucial for seizure suppression and postictal sleep

(2013) Mahesh K. Kaushik et al.   EXPERIMENTAL NEUROLOGY

Prostanoid Receptor EP2 as a Therapeutic Target

(2013) Thota Ganesh   JOURNAL OF MEDICINAL CHEMISTRY

Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury

(2013) Alexander V Glushakov et al.   Journal of Neuroinflammation

Oxidative Burst of Circulating Neutrophils Following Traumatic Brain Injury in Human

(2013) Yiliu Liao et al.   PLoS One

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

(2013) Jianxiong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

(2013) Jianxiong Jiang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Reduction in delayed mortality and subtle improvement in retrograde memory performance in pilocarpine-treated mice with conditional neuronal deletion of cyclooxygenase-2 gene

(2012) Jamie R. Levin et al.   EPILEPSIA

Aspirin Use in Sturge-Weber Syndrome

(2012) Eboni I. Lance et al.   JOURNAL OF CHILD NEUROLOGY

Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity

(2012) Yun Tai Kim et al.   NEUROBIOLOGY OF DISEASE

Immunohistochemical demonstration of increased prostaglandin F2α levels in the rat hippocampus following kainic acid-induced seizures

(2012) S. Takei et al.   NEUROSCIENCE

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

(2012) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals

(2011) Tsuyoshi Tajima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cyclooxygenase-2 inhibitors: a literature and patent review (2009 – 2010)

(2011) Baker Jawabrah Al-Hourani et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus

(2011) G. E. Serrano et al.   JOURNAL OF NEUROSCIENCE

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga

(2010) Tilo Grosser et al.   Annual Review of Medicine

Modulating P-glycoprotein regulation: Future perspectives for pharmacoresistant epilepsies?

(2010) Heidrun Potschka   EPILEPSIA

Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy

(2010) Linda Holtman et al.   EPILEPSY RESEARCH

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

(2010) Nadine Polascheck et al.   EXPERIMENTAL NEUROLOGY

Estimating risk for developing epilepsy: A population-based study in Rochester, Minnesota

(2010) D. C. Hesdorffer et al.   NEUROLOGY

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

(2009) L. Holtman et al.   EPILEPSY RESEARCH

Induction of COX-2/PGE2/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent NADPH oxidase activation

(2009) Chih-Chung Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Prostaglandin E2 EP1 Receptors Prevents Seizure-Associated P-glycoprotein Up-Regulation

(2009) A. Pekcec et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

(2009) Erwin A. van Vliet et al.   NEUROPHARMACOLOGY

PGF2α FP Receptor Contributes to Brain Damage Following Transient Focal Brain Ischemia

(2009) Sofiyan Saleem et al.   NEUROTOXICITY RESEARCH

Involvement of endogenous prostaglandin F2α on kainic acid-induced seizure activity through FP receptor: The mechanism of proconvulsant effects of COX-2 inhibitors

(2008) Hee-Jae Kim et al.   BRAIN RESEARCH

Acceleration of Cardiovascular Disease by a Dysfunctional Prostacyclin Receptor Mutation

(2008) Eric Arehart et al.   CIRCULATION RESEARCH

Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures

(2008) Mauro Schneider Oliveira et al.   EPILEPSY RESEARCH

Central prostaglandin D2stimulates food intake via the neuropeptide Y system in mice

(2008) Kousaku Ohinata et al.   FEBS LETTERS

Modulation of pentylenetetrazol-induced seizures by prostaglandin E2 receptors

(2008) M.S. Oliveira et al.   NEUROSCIENCE

Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: Possible involvement of adenosinergic mechanism

(2007) Kiran Kumar Akula et al.   EPILEPSY RESEARCH