Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs

Overexpressing dominant-negative FGFR2-IIIb impedes lung branching morphogenesis in pigs

(2018) Qin Chen et al.   Journal of Genetics and Genomics

The phenomenon of atherosclerosis reversal and regression: Lessons from animal models

(2017) Dimitry A. Chistiakov et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

CRISPR/Cas9-mediated ApoE-/- and LDLR-/- double gene knockout in pigs elevates serum LDL-C and TC levels

(2017) Lei Huang et al.   Oncotarget

Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting

(2017) Wei Zhang et al.   Scientific Reports

ApoE knockout rabbits: A novel model for the study of human hyperlipidemia

(2016) Manabu Niimi et al.   ATHEROSCLEROSIS

Development of Human‐Like Advanced Coronary Plaques in Low‐Density Lipoprotein Receptor Knockout Pigs and Justification for Statin Treatment Before Formation of Atherosclerotic Plaques

(2016) Yuxin Li et al.   Journal of the American Heart Association

Generation of B Cell-Deficient Pigs by Highly Efficient CRISPR/Cas9-Mediated Gene Targeting

(2015) Fengjiao Chen et al.   Journal of Genetics and Genomics

Acute and persistent platelet and coagulant activities in atherothrombosis

(2015) T. G. Mastenbroek et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Apolipoprotein E in Alzheimer's Disease: An Update

(2014) Jin-Tai Yu et al.   Annual Review of Neuroscience

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

(2014) Tang Hai et al.   CELL RESEARCH

Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease

(2014) Luz M. Reyes et al.   JOURNAL OF IMMUNOLOGY

Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs

(2014) Bryan T. Davis et al.   PLoS One

Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans

(2013) Peter Libby et al.   IMMUNITY

ApoE Production in Human Monocytes and Its Regulation by Inflammatory Cytokines

(2013) Sten Braesch-Andersen et al.   PLoS One

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant

(2013) R. H. Al-Mashhadi et al.   Science Translational Medicine

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing

(2012) G Davies et al.   MOLECULAR PSYCHIATRY

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia

(2011) Dimitra Georgiadou et al.   PLoS One

Atherosclerotic lesions in mouse and man: is it the same disease?

(2010) Jacob Fog Bentzon et al.   CURRENT OPINION IN LIPIDOLOGY

Transgenic pigs as models for translational biomedical research

(2010) Bernhard Aigner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM