标题
Aurora Kinase Inhibitors: Current Status and Outlook
作者
关键词
-
出版物
Frontiers in Oncology
Volume 5, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2015-12-21
DOI
10.3389/fonc.2015.00278
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy
- (2015) G. Borthakur et al. HAEMATOLOGICA
- Aurora Kinase Inhibition: A New Light in the Sky?
- (2015) Spiros Linardopoulos et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of N-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally Bioavailable Inhibitor of Aurora Kinases with Activity against Multidrug-Resistant Cancer Cell Lines
- (2015) Stephanie Geuns-Meyer et al. JOURNAL OF MEDICINAL CHEMISTRY
- MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
- (2015) Todd B. Sells et al. ACS Medicinal Chemistry Letters
- A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy
- (2015) G. Borthakur et al. HAEMATOLOGICA
- Efficacy and safety of biweekly i.v. administrations of the Aurora kinase inhibitor danusertib hydrochloride in independent cohorts of patients with advanced or metastatic breast, ovarian, colorectal, pancreatic, small-cell and non-small-cell lung cancer: a multi-tumour, multi-institutional phase II study
- (2014) P. Schoffski et al. ANNALS OF ONCOLOGY
- Drugging MYCN through an Allosteric Transition in Aurora Kinase A
- (2014) William Clay Gustafson et al. CANCER CELL
- The selective Aurora-A kinase inhibitor MLN8237 (alisertib) potently inhibits proliferation of glioblastoma neurosphere tumor stem-like cells and potentiates the effects of temozolomide and ionizing radiation
- (2014) Xin Hong et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- A Phase I Trial of AT9283 (a Selective Inhibitor of Aurora Kinases) in Children and Adolescents with Solid Tumors: A Cancer Research UK Study
- (2014) L. Moreno et al. CLINICAL CANCER RESEARCH
- Stage I of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia
- (2013) Hagop M. Kantarjian et al. CANCER
- Phase I Study Assessing the Safety and Tolerability of Barasertib (AZD1152) With Low-Dose Cytosine Arabinoside in Elderly Patients With AML
- (2013) Hagop M. Kantarjian et al. Clinical Lymphoma Myeloma & Leukemia
- A Phase I and Pharmacodynamic Study of AT9283, a Small-Molecule Inhibitor of Aurora Kinases in Patients With Relapsed/Refractory Leukemia or Myelofibrosis
- (2013) James Foran et al. Clinical Lymphoma Myeloma & Leukemia
- NCIC CTG IND.181: Phase I study of AT9283 given as a weekly 24 hour infusion in advanced malignancies
- (2013) S. F. Dent et al. INVESTIGATIONAL NEW DRUGS
- Phase I study of MLN8237—investigational Aurora A kinase inhibitor—in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia
- (2013) Kevin R. Kelly et al. INVESTIGATIONAL NEW DRUGS
- Phase II Study of Alisertib, a Selective Aurora A Kinase Inhibitor, in Relapsed and Refractory Aggressive B- and T-Cell Non-Hodgkin Lymphomas
- (2013) Jonathan W. Friedberg et al. JOURNAL OF CLINICAL ONCOLOGY
- AMG 900, a Small-Molecule Inhibitor of Aurora Kinases, Potentiates the Activity of Microtubule-Targeting Agents in Human Metastatic Breast Cancer Models
- (2013) Tammy L. Bush et al. MOLECULAR CANCER THERAPEUTICS
- Randomized phase II study of danusertib in patients with metastatic castration-resistant prostate cancer after docetaxel failure
- (2012) Hielke J. Meulenbeld et al. BJU INTERNATIONAL
- Phase I study of the Aurora B kinase inhibitor barasertib (AZD1152) to assess the pharmacokinetics, metabolism and excretion in patients with acute myeloid leukemia
- (2012) Mike Dennis et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Pediatric Phase I Trial and Pharmacokinetic Study of MLN8237, an Investigational Oral Selective Small-Molecule Inhibitor of Aurora Kinase A: A Children's Oncology Group Phase I Consortium Study
- (2012) Y. P. Mosse et al. CLINICAL CANCER RESEARCH
- Phase I Pharmacokinetic/Pharmacodynamic Study of MLN8237, an Investigational, Oral, Selective Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors
- (2012) A. Cervantes et al. CLINICAL CANCER RESEARCH
- Phase I Study of Aurora A Kinase Inhibitor MLN8237 in Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics, and Bioavailability of Two Oral Formulations
- (2012) E. C. Dees et al. CLINICAL CANCER RESEARCH
- Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma
- (2012) Ursula A. Matulonis et al. GYNECOLOGIC ONCOLOGY
- Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism
- (2012) Kevin R. Kelly et al. INTERNATIONAL JOURNAL OF CANCER
- Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors
- (2012) Gary K. Schwartz et al. INVESTIGATIONAL NEW DRUGS
- Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia
- (2012) Vassilios Bavetsias et al. JOURNAL OF MEDICINAL CHEMISTRY
- Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns
- (2012) A S Moore et al. LEUKEMIA
- The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
- (2012) Mar Carmena et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies
- (2011) H.- T. Arkenau et al. ANNALS OF ONCOLOGY
- Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia
- (2011) B. Lowenberg et al. BLOOD
- Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer
- (2011) Hernan Carol et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Aurora B kinase inhibition in mitosis: Strategies for optimizing the use of Aurora kinase inhibitors such as AT9283
- (2011) Jayne Curry et al. CELL CYCLE
- The Aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe
- (2011) Yungan Tao et al. CELL CYCLE
- Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays
- (2011) M. G. Manfredi et al. CLINICAL CANCER RESEARCH
- A Complex of Kif18b and MCAK Promotes Microtubule Depolymerization and Is Negatively Regulated by Aurora Kinases
- (2011) Marvin E. Tanenbaum et al. CURRENT BIOLOGY
- Phase I, open-label, multicentre, dose-escalation, pharmacokinetic and pharmacodynamic trial of the oral aurora kinase inhibitor PF-03814735 in advanced solid tumours
- (2011) Patrick Schöffski et al. EUROPEAN JOURNAL OF CANCER
- The clinical development of FLT3 inhibitors in acute myeloid leukemia
- (2011) Steven Knapper EXPERT OPINION ON INVESTIGATIONAL DRUGS
- AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas
- (2011) Wenqing Qi et al. INTERNATIONAL JOURNAL OF CANCER
- A Phase I study to assess the safety, pharmacokinetics and efficacy of barasertib (AZD1152), an Aurora B kinase inhibitor, in Japanese patients with advanced acute myeloid leukemia
- (2011) Kosuke Tsuboi et al. LEUKEMIA RESEARCH
- The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-Amplified Neuroblastoma In Vivo
- (2011) A. Faisal et al. MOLECULAR CANCER THERAPEUTICS
- Overexpression of Active Aurora-C Kinase Results in Cell Transformation and Tumour Formation
- (2011) Jabbar Khan et al. PLoS One
- Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors
- (2010) D. S. Boss et al. ANNALS OF ONCOLOGY
- Will newer tyrosine kinase inhibitors have an impact in AML?
- (2010) Mark J. Levis BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
- Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells
- (2010) R. Tanaka et al. BLOOD
- Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
- (2010) M. Payton et al. CANCER RESEARCH
- Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition
- (2010) Tony Sourisseau et al. EMBO Molecular Medicine
- The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib
- (2010) Kevin R. Kelly et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias
- (2010) A S Moore et al. LEUKEMIA
- Aurora-C Kinase Deficiency Causes Cytokinesis Failure in Meiosis I and Production of Large Polyploid Oocytes in Mice
- (2010) Kuo-Tai Yang et al. MOLECULAR BIOLOGY OF THE CELL
- The FLT3 Internal Tandem Duplication Mutation Is a Secondary Target of the Aurora B Kinase Inhibitor AZD1152-HQPA in Acute Myelogenous Leukemia Cells
- (2010) M. Grundy et al. MOLECULAR CANCER THERAPEUTICS
- PF-03814735, an Orally Bioavailable Small Molecule Aurora Kinase Inhibitor for Cancer Therapy
- (2010) Jitesh P. Jani et al. MOLECULAR CANCER THERAPEUTICS
- Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma
- (2009) Tobias Otto et al. CANCER CELL
- AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo
- (2009) A. Oke et al. CANCER RESEARCH
- A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors
- (2009) R. B. Cohen et al. CLINICAL CANCER RESEARCH
- Phase I Pharmacokinetic and Pharmacodynamic Study of the Aurora Kinase Inhibitor Danusertib in Patients With Advanced or Metastatic Solid Tumors
- (2009) Neeltje Steeghs et al. JOURNAL OF CLINICAL ONCOLOGY
- Determinants for the efficiency of anticancer drugs targeting either Aurora-A or Aurora-B kinases in human colon carcinoma cells
- (2009) P. Kaestner et al. MOLECULAR CANCER THERAPEUTICS
- Aurora Kinases as Anticancer Drug Targets
- (2008) O. Gautschi et al. CLINICAL CANCER RESEARCH
- Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts
- (2008) E. Walsby et al. HAEMATOLOGICA
- Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity†
- (2008) Steven Howard et al. JOURNAL OF MEDICINAL CHEMISTRY
- Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
- (2008) Libor Macůrek et al. NATURE
- Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry
- (2008) A. Seki et al. SCIENCE
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