Article
Oncology
Thomas J. Semrad, Edward J. Kim, I-Yeh Gong, Tianhong Li, Scott Christensen, Mili Arora, Jonathan W. Riess, David R. Gandara, Karen Kelly
Summary: This study aimed to evaluate the safety and tolerability of the Aurora A kinase inhibitor alisertib in combination with weekly irinotecan. The results showed that adult patients were unable to tolerate the combination treatment at clinically meaningful doses due to hematologic and gastrointestinal toxicities.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Oncology
Yaman Tayyar, Adi Idris, Josif Vidimce, Danyelle Assis Ferreira, Nigel A. J. McMillan
Summary: HPV E7 sensitizes cells to inhibition of aurora kinases, while HPV oncogenes sensitize cells to inhibition of phosphoinositide 3-kinases. Research has shown that treatment with Alisertib combined with radiotherapy or a PI3K inhibitor can improve tumor response, suggesting potential for further clinical development of these combinations.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Thiago L. Da Costa Almeida, Andressa R. Rodrigues, Mucio Cirino, Felipe A. Trevisan, Fernanda Peria, Daniela Tirapelli, Carlos Gilberto Carlotti Jr
Summary: This study evaluated the expression of genes and miRNAs in glioblastoma cell lines after treatment with temozolomide and ionizing radiation. The results showed changes in gene expression and miRNA profiles, with ionizing radiation being an independent and determining factor for radioresistance in neurospheres.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Carolin Seifert, Ellen Balz, Susann Herzog, Anna Korolev, Sebastian Gassmann, Heiko Paland, Matthias A. Fink, Markus Grube, Sascha Marx, Gabriele Jedlitschky, Mladen Tzvetkov, Bernhard H. Rauch, Henry W. S. Schroeder, Sandra Bien-Moeller
Summary: Research has shown that PIM1 kinase plays a significant role in the behavior of glioblastoma stem cells, and its inhibition can lead to the death of these stem-like cells, suggesting a potential approach for glioblastoma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jorge A. Benitez, Darren Finlay, Anthony Castanza, Alison D. Parisian, Jianhui Ma, Ciro Longobardi, Alex Campos, Raghavendra Vadla, Alejandro Izurieta, Gianluca Scerra, Tomoyuki Koga, Tao Long, Lukas Chavez, Jill P. Mesirov, Kristiina Vuori, Frank Furnari
Summary: The study identified a potential therapeutic strategy for GBM by targeting proteasome inhibition, which showed high sensitivity in GSCs due to their reliance on increased protein synthesis rate and loss of autophagy. Combinatorial inhibition of proteasome and autophagy resulted in enhanced cytotoxicity in PTEN-expressing GSCs, suggesting a synthetic lethal approach for this subset of GBM patients.
Editorial Material
Biochemistry & Molecular Biology
Kirit Singh, Kelly M. Hotchkiss, Ian F. Parney, John De Groot, Solmaz Sahebjam, Nader Sanai, Michael Platten, Evanthia Galanis, Michael Lim, Patrick Y. Wen, Giuseppe Minniti, Howard Colman, Timothy F. Cloughesy, Minesh P. Mehta, Marjolein Geurts, Isabel Arrillaga-Romany, Annick Desjardins, Kirk Tanner, Susan Short, David Arons, Elizabeth Duke, Wolfgang Wick, Stephen J. Bagley, David M. Ashley, Priya Kumthekar, Roel Verhaak, Anthony J. Chalmers, Anoop P. Patel, Colin Watts, Peter E. Fecci, Tracy T. Batchelor, Michael Weller, Michael A. Vogelbaum, Matthias Preusser, Mitchel S. Berger, Mustafa Khasraw
Summary: A breakthrough in drug discovery for glioblastoma necessitates the consecutive collection of central nervous system tissue through window of opportunity trials.
Article
Gastroenterology & Hepatology
Yuebo Zhang, Yong Ma, Ying Wang, Debabrata Mukhopadhyay, Yan Bi, Baoan Ji
Summary: This study found that Aurora kinase-A is overexpressed in PDAC, and its inhibitor MLN8237 can effectively inhibit the proliferation and migration of PDAC cells, as well as suppress tumor growth in animal models. This provides a new chemotherapy strategy for PDAC patients.
Article
Oncology
Kian-Huat Lim, Mateusz Opyrchal, Abhi Acharya, Nick Boice, Ningying Wu, Feng Gao, Jace Webster, Albert C. Lockhart, Saiama N. Waqar, Ramaswamy Govindan, Daniel Morgensztern, Joel Picus, Benjamin R. Tan, Maria Q. Baggstrom, Christopher A. Maher, Andrea Wang-Gillam
Summary: The study evaluated the efficacy and safety of the combination of AURKA inhibitor (alisertib) and paclitaxel in patients with refractory high-grade neuroendocrine tumors (NETs). The combination treatment demonstrated manageable side-effect profile and promising preliminary efficacy in high-grade NETs, warranting further testing.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Susanne Flor, Claudia R. Oliva, Md Yousuf Ali, Kristen L. Coleman, Jeremy D. Greenlee, Karra A. Jones, Varun Monga, Corinne E. Griguer
Summary: Glioblastoma, the deadliest form of brain cancer, often becomes resistant to standard treatments due to the upregulation of antioxidant catalase (CAT) which enhances resistance to chemotherapy and radiation, decreases survival rates, and enriches glioma stem cell populations.
Article
Oncology
Arvind Pandey, Satyendra C. Tripathi, Junhua Mai, Samir M. Hanash, Haifa Shen, Sankar Mitra, Robert C. Rostomily
Summary: New strategies are urgently needed to improve the dismal median survivals of only ~15-20 months for glioblastoma (GBM) patients after the current standard of care treatment. This study demonstrates the potential importance of PLK1 inhibitors as an adjunct to GBM therapy, with novel mechanisms of action identified for volasertib.
Article
Medicine, Research & Experimental
Dongjiang Chen, Son B. Le, Tarun E. Hutchinson, Anda-Alexandra Calinescu, Mathew Sebastian, Dan Jin, Tianyi Liu, Ashley Ghiaseddin, Maryam Rahman, David D. Tran
Summary: TTFields, a novel therapy for GBM and other solid tumors, disrupts mitotic spindle and induces inflammation to exert its anti-tumor effects. The study reveals that TTFields can activate DNA sensors and inflammasomes to produce immune response, leading to antitumor immunity and cure.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Hong Shik Yun, Jennifer Lee, Whoon Jong Kil, Tamalee R. Kramp, Philip J. Tofilon, Kevin Camphausen
Summary: AZD0530, a potent small-molecule inhibitor of the Src kinase family, enhances the radiosensitivity of glioblastoma cells and glioblastoma stem-like cells, showing potential as a clinical radiosensitizer for the treatment of glioblastoma.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Edikan A. Ogunnaike, Alain Valdivia, Mostafa Yazdimamaghani, Ernesto Leon, Seema Nandi, Hannah Hudson, Hongwei Du, Simon Khagi, Zhen Gu, Barbara Savoldo, Frances S. Ligler, Shawn Hingtgen, Gianpietro Dotti
Summary: The delivery of CAR-T cells within the surgical cavity using a fibrin-based gel demonstrates superior antitumor activity compared to direct inoculation into the tumor resection cavity in a model of subtotal glioblastoma resection.
Review
Medicine, Research & Experimental
A. M. Moras, J. G. Henn, L. Steffens Reinhardt, G. Lenz, D. J. Moura
Summary: Glioblastoma is a common and malignant brain tumor with a short survival period and low cure rate. Research on resistance mechanisms related to DNA damage repair pathways, glioma stem cells, blood-brain barrier, and systemic treatment, as well as the development of localized treatments, could improve survival rates and quality of life for patients.
Article
Oncology
Youri Hoogstrate, Kaspar Draaisma, Santoesha A. Ghisai, Levi van Hijfte, Nastaran Barin, Iris de Heer, Wouter Coppieters, Thierry P. P. van den Bosch, Anne Bolleboom, Zhenyu Gao, Arnaud J. P. E. Vincent, Latifa Karim, Manon Deckers, Martin J. B. Taphoorn, Melissa Kerkhof, Astrid Weyerbrock, Marc Sanson, Ann Hoeben, Slavka Lukacova, Giuseppe Lombardi, Sieger Leenstra, Monique Hanse, Ruth E. M. Fleischeuer, Colin Watts, Nicos Angelopoulos, Thierry Gorlia, Vassilis Golfinopoulos, Vincent Bours, Martin J. van den Bent, Pierre A. Robe, Pim J. French
Summary: A better understanding of the transcriptional evolution of IDH-wild-type glioblastoma is crucial for optimizing treatment. Through RNA sequencing, this study demonstrates that glioblastomas mainly evolve through microenvironmental reorganization rather than molecular evolution of tumor cells. The changes in tumor composition over time, including alterations in neuron and oligodendrocyte marker genes and an increase in tumor-associated macrophages, are confirmed by single-cell RNA-seq and immunohistochemistry.
Article
Biology
James Grutsch, William Hrushesky, Christopher Lis, Robert Levin, Tim Birdsall, Patricia Wood, Dinah Faith Huff, Justin Reynolds, Dennis Pearl, Xiaotong Shen, Digant Gupta, David Blask
Summary: Evening melatonin supplementation improved overall survival rates in advanced non-small cell lung cancer patients, especially those with self-reported normal sleep quality.
BIOLOGICAL RHYTHM RESEARCH
(2022)
Article
Education & Educational Research
Dennis K. Pearl, Lawrence M. Lesser
Summary: Using humor such as jokes and cartoons, as well as engaging mediums like songs and videos, can engage students and help them learn key concepts about polling in an interactive way.
TEACHING STATISTICS
(2021)
Article
Oncology
Belinda J. Petri, Kellianne M. Piell, Gordon C. South Whitt, Ali E. Wilt, Claire C. Poulton, Norman L. Lehman, Brian F. Clem, Matthew A. Nystoriak, Marcin Wysoczynski, Carolyn M. Klinge
Summary: The RNA binding protein and m6A reader HNRNPA2B1 is overexpressed in breast tumors compared to normal tissue. Overexpression of A2B1 leads to tamoxifen and fulvestrant resistance, while knockdown of A2B1 restores endocrine sensitivity. Targeting A2B1 could be a potential therapeutic strategy to overcome acquired endocrine resistance in breast cancer.
Article
Pathology
Khaled J. Alkhateeb, Jason E. Crane, Muge Sak, Caitlin J. Jorgensen, James P. O'Donnell, Cory T. Zumbar, Jason A. Wozniak, Clarence R. Salazar, Anil Parwani, Norman L. Lehman
Summary: Aurora-A kinase shows differential expression in normal Mullerian epithelium, benign and borderline serous and mucinous ovarian epithelial neoplasms, and malignant serous ovarian tumors. Nuclear expression of unphosphorylated Aurora-A is present in normal and benign neoplastic epithelium, but lost in malignant serous neoplasms. Further studies on the clinical implications and role of nuclear Aurora-A expression loss in ovarian tumors are warranted.
DIAGNOSTIC PATHOLOGY
(2021)
Article
Education & Educational Research
Lawrence M. Lesser, Dennis K. Pearl
Summary: Edutainment fun items have the potential to engage students in discussing and learning key concepts about probability.
TEACHING STATISTICS
(2022)
Article
Multidisciplinary Sciences
Norman L. Lehman, Nathalie Spassky, Muge Sak, Amy Webb, Cory T. Zumbar, Aisulu Usubalieva, Khaled J. Alkhateeb, Joseph P. McElroy, Kirsteen H. Maclean, Paolo Fadda, Tom Liu, Vineela Gangalapudi, Jamie Carver, Zied Abdullaev, Cynthia Timmers, John R. Parker, Christopher R. Pierson, Bret C. Mobley, Murat Gokden, Eyas M. Hattab, Timothy Parrett, Ralph X. Cooke, Trang D. Lehman, Stefan Costinean, Anil Parwani, Brian J. Williams, Randy L. Jensen, Kenneth Aldape, Akshitkumar M. Mistry
Summary: Astroblastomas (ABs) are rare brain tumors with unknown origin. Molecular analysis suggests that these tumors arise from neural progenitor cells and are associated with epigenetic and genetic changes occurring during brain development.
NATURE COMMUNICATIONS
(2022)
Article
Education & Educational Research
Dennis K. Pearl, Lawrence M. Lesser
Summary: Edutainment fun items can facilitate students' engagement in discussions and learning of key concepts in descriptive statistics.
TEACHING STATISTICS
(2022)
Editorial Material
Education & Educational Research
Lawrence M. Lesser, Dennis K. Pearl
Summary: Readers are invited to participate in a data collection exercise that will be used in the subsequent series.
TEACHING STATISTICS
(2022)
Review
Oncology
Norman L. Lehman
Summary: This article reviews the clinicopathologic and genetic features of early ependymal tumor with MN1-BEND2 fusion (EET MN1-BEND2), classical astroblastomas, and recently described related pediatric CNS tumors. The discovery of genomic DNA methylation profiling as a powerful tool for CNS tumor classification is also briefly discussed. The article concludes that although genomic DNA profiling has facilitated the discovery of new CNS tumor entities, traditional methods are still necessary for accurate classification and diagnosis.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Education & Educational Research
Dennis K. Pearl, Lawrence M. Lesser
Summary: The concepts of experimentation and measurement are examined using statistics educational fun items and demonstrated through the process of conducting an experiment on cartoon captions.
TEACHING STATISTICS
(2023)
Article
Education & Educational Research
Lawrence M. Lesser, Dennis K. Pearl
Summary: The concepts of data visualization are explored through the use of statistics educational fun items, and illustrated by sharing the results of our experiment on cartoon captions.
TEACHING STATISTICS
(2023)
Article
Education, Scientific Disciplines
Sabrina Luxin Wang, Anna Yinqi Zhang, Samuel Messer, Andrew Wiesner, Dennis K. Pearl
Summary: This article discusses a set of student-created Shiny apps designed for teaching statistics, with a field test to assess their short-term effectiveness. Over 50 Shiny apps have been developed along with accompanying lesson plans to enhance teaching in introductory and advanced statistics courses. The experimental testing of four of these apps showed positive short-term learning outcomes for students in an introductory statistical concepts course.
JOURNAL OF STATISTICS AND DATA SCIENCE EDUCATION
(2021)
Article
Education & Educational Research
Lawrence M. Lesser, Dennis K. Pearl
Summary: Engaging students in discussion and learning key concepts about hypothesis testing can be facilitated through the use of jokes, cartoons, songs, and games.
TEACHING STATISTICS
(2021)
Article
Education & Educational Research
Dennis K. Pearl, Lawrence M. Lesser
Summary: Using entertainment forms such as jokes, cartoons, and games can help students better engage in learning key concepts about regression.
TEACHING STATISTICS
(2021)
Article
Education & Educational Research
Lawrence M. Lesser, Dennis K. Pearl
TEACHING STATISTICS
(2020)
