Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation

Temperature-variable NMR Study of the keto-enol Tautomerism of Phenylpyruvic Acid

(2018) Toshiki YAMAJI et al.   ANALYTICAL SCIENCES

Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics

(2018) Florian Adanitsch et al.   Chemical Science

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

Proportion and Cost of Unplanned 30-Day Readmissions After Sepsis Compared With Other Medical Conditions

(2017) Florian B. Mayr et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Potential role of an antimicrobial peptide, KLK in inhibiting lipopolysaccharide-induced macrophage inflammation

(2017) Pornpimon Jantaruk et al.   PLoS One

Evidence of NI-0101 pharmacological activity, an anti-TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS

(2016) E Monnet et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Sepsis—The Final Common Pathway to Death From Multiple Organ Failure in Infection

(2016) Niranjan Kissoon et al.   CRITICAL CARE MEDICINE

Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy

(2016) Anders Perner et al.   INTENSIVE CARE MEDICINE

MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis

(2015) Yi Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation

(2015) Jing Li et al.   ChemMedChem

Rehospitalizations Following Sepsis

(2015) Dong W. Chang et al.   CRITICAL CARE MEDICINE

Species and mediator specific TLR4 antagonism in primary human and murine immune cells by βGlcN(1↔1)αGlc based lipid A mimetics

(2015) Chiranjeevi Chebrolu et al.   MOLECULAR IMMUNOLOGY

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance

(2015) Rajesh Rajaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kdo2-lipid A: structural diversity and impact on immunopharmacology

(2014) Xiaoyuan Wang et al.   BIOLOGICAL REVIEWS

Chemistry of Lipid A: At the Heart of Innate Immunity

(2014) Antonio Molinaro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold

(2014) Jose Antonio Garate et al.   Innate Immunity

Development of αGlcN(1↔1)αMan-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists

(2014) Florian Adanitsch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Strategies to improve drug development for sepsis

(2014) Mitchell P. Fink et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Key Residues That Confer Rhodobacter sphaeroides LPS Activity at Horse TLR4/MD-2

(2014) Katherine L. Irvine et al.   PLoS One

Conformationally Constrained Lipid A Mimetics for Exploration of Structural Basis of TLR4/MD-2 Activation by Lipopolysaccharide

(2013) Daniel Artner et al.   ACS Chemical Biology

Immunotherapy for the Adjunctive Treatment of Sepsis: From Immunosuppression to Immunostimulation. Time for a Paradigm Change?

(2013) Jenneke Leentjens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis

(2013) Brittany D. Needham et al.   NATURE REVIEWS MICROBIOLOGY

Targeting Toll-Like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases

(2013) Athina Savva et al.   Frontiers in Immunology

Sepsis studies need new direction

(2012) Jonathan Cohen et al.   LANCET INFECTIOUS DISEASES

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD-2

(2012) P. Rallabhandi et al.   mBio

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

(2011) Amisha Barochia et al.   Expert Opinion on Drug Metabolism & Toxicology

Deactivation of the lipopolysaccharide antagonist eritoran (E5564) by high-density lipoprotein-associated apolipoproteins

(2011) Jacklyn G Fleischer et al.   Innate Immunity

From agonist to antagonist: Structure and dynamics of innate immune glycoprotein MD-2 upon recognition of variably acylated bacterial endotoxins

(2011) Mari L. DeMarco et al.   MOLECULAR IMMUNOLOGY

Myeloid differentiation 2 as a therapeutic target of inflammatory disorders

(2011) Sun Hong Park et al.   PHARMACOLOGY & THERAPEUTICS

Robust routes for the synthesis of N-acylated-l-homoserine lactone (AHL) quorum sensing molecules with high levels of enantiomeric purity

(2011) James T. Hodgkinson et al.   TETRAHEDRON LETTERS

Development of LPS antagonistic therapeutics: synthesis and evaluation of glucopyranoside-spacer-amino acid motifs

(2011) Sophon Kaeothip et al.   RSC Advances

Improved Ligand-Protein Binding Affinity Predictions Using Multiple Binding Modes

(2010) Eva Stjernschantz et al.   BIOPHYSICAL JOURNAL

Dansyl C-Glucoside as a Novel Agent Against Endotoxic Shock

(2010) Barbara La Ferla et al.   ChemMedChem

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

The catalytic effect of water on the keto–enol tautomerism. Pyruvate and acetylacetone: a computational challenge

(2010) Giuliano Alagona et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

(2009) T. Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of Monomeric and Dimeric Secreted MD-2

(2008) Athmane Teghanemt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES