☆ 4.7 Editorial Material

Sepsis studies need new direction

LANCET INFECTIOUS DISEASES (2012)

期刊

LANCET INFECTIOUS DISEASES

卷 12, 期 7, 页码 503-505

出版社

ELSEVIER SCIENCE INC

DOI: 10.1016/S1473-3099(12)70136-6

关键词

-

类别

Infectious Diseases

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Anesthesiology

What's new on septic encephalopathy? Ten things you need to know

Lorenzo Ferlini, Nicolas Gaspard

Summary: Sepsis associated encephalopathy (SAE) is a common complication of sepsis and is linked to higher short-term mortality and long-term cognitive impairment. EEG can effectively detect and quantify encephalopathy in SAE patients and identify prognostic features. Neuroinflammation and altered cerebral blood flow regulation play crucial roles in the development of SAE, and recent studies have shown promising biomarkers and therapeutic targets.

MINERVA ANESTESIOLOGICA (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Genetic Variants of Matrix Metalloproteinase and Sepsis: The Need Speed Study

Nicola Fiotti, Filippo Mearelli, Filippo Giorgio Di Girolamo, Luigi Mario Castello, Alessio Nunnari, Salvatore Di Somma, Enrico Lupia, Efrem Colonetti, Maria Lorenza Muiesan, Giuseppe Montrucchio, Carlo Giansante, Gian Carlo Avanzi, Gianni Biolo

Summary: The genetic polymorphisms of matrix metalloproteinases (MMPs) and their tissue inhibitor (TIMP1) may be associated with susceptibility and etiology of sepsis. Certain genetic variants were found to be associated with increased risk of sepsis, specific pathogen infections, and clinical manifestations.

BIOMOLECULES (2022)

添加到收藏夹

Article Medicine, General & Internal

The Need of Enterococcal Coverage in Severe Intra-Abdominal Infection: Evidence from Animal Study

Min Ji Lee, Tae Nyoung Chung, Ye Jin Park, Han A. Reum Lee, Jung Ho Lee, Chang June Yune, Jinkun Bae, Sehwan Mun, Jeong Su Park, Kyuseok Kim

Summary: In a severe polymicrobial intra-abdominal infection (IAI) model, imipenem/cilastatin (IMP) improved survival and bacterial clearance compared to ceftriaxone with metronidazole (CTX + M), reducing plasma lactate, cytokine, and ROS levels while lowering ALT and creatinine levels. However, in a mild-to-moderate IAI model, there was no difference in survival between the groups. Immune suppression of peripheral blood mononuclear cells (PBMCs) was observed in the IAI model, particularly in the severe IAI model, where IMP showed better outcomes than CTX + M.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Correction Pediatrics

Neonatal sepsis: need for consensus definition, collaboration and core outcomes (vol 88, pg 2, 2020)

Eleanor J. Molloy, James L. Wynn, Joseph Bliss, Joyce M. Koenig, Fleur M. Keij, Matt McGovern, Helmut Kuester, Mark A. Turner, Eric Giannoni, Jan Mazela, Marina Degtyareva, Tobias Strunk, Sinno H. P. Simons, Jan Janota, Franz B. Plotz, Ages van den Hoogen, Willem de Boode, Luregn J. Schlapbach, Irwin K. M. Reiss

Summary: The paper has been amended and the revised version can be accessed through a link at the top of the paper.

PEDIATRIC RESEARCH (2021)

添加到收藏夹

Article Chemistry, Applied

Active compounds: A new direction for rice value addition

Zhaoqiang Jin, Shaobing Peng, Lixiao Nie

Summary: This paper focuses on the types and effects of active compounds in rice and summarizes the impact of storage and processing technology on rice active compounds. It concludes that rice contains numerous active compounds beneficial to humans. However, the research on the mechanism of action of rice active compounds on the human body is not deep enough, and the ability to deeply process rice is insufficient, greatly limiting the development of the rice active compound industry. To maximize the added value of rice, it is necessary to establish a dedicated preservation and processing technology system based on the physicochemical properties of the required active compounds. Additionally, attention should be paid to the development and application of composite technologies during the development of the rice active compound industry.

FOOD CHEMISTRY-X (2023)

添加到收藏夹

Article Neurosciences

Sepsis-Associated Encephalopathy: from Pathophysiology to Progress in Experimental Studies

Anderson Velasque Catarina, Gisele Branchini, Lais Bettoni, Jarbas Rodrigues De Oliveira, Fernanda Bordignon Nunes

Summary: Sepsis, a major cause of morbidity and mortality in ICUs worldwide, can lead to severe brain injuries. Sepsis-associated encephalopathy is primarily caused by inflammatory and oxidative processes, with damage to the blood-brain barrier playing a significant role. Further studies and experimental advancements are crucial for understanding the complex pathophysiology of SAE and developing effective treatments and therapies.

MOLECULAR NEUROBIOLOGY (2021)

添加到收藏夹

Review Oncology

A New Antitumor Direction: Tumor-Specific Endothelial Cells

Jing Liang, Shouqi Wang, Guowei Zhang, Baoyu He, Qingli Bie, Bin Zhang

Summary: Studying the differences, heterogeneity, and interaction of tumor-specific endothelial cells (TECs) with the tumor microenvironment is crucial for developing specific anti-tumor angiogenesis therapies.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Fibrosis-4 Predicts the Need for Mechanical Ventilation in a National Multiethnic Cohort of Corona Virus Disease 2019

Richard K. Sterling, Dongho Shin, Yongyun Shin, Evan French, Michael P. Stevens, Jasmohan S. Bajaj, Marjolein DeWit, Arun J. Sanyal

Summary: This study found an association between FIB-4 and the need for MV in patients with COVID-19, with the optimal FIB-4 cutoff identified as 3.04. Increasing FIB-4 was found to be predictive of the need for MV in patients of different races.

HEPATOLOGY COMMUNICATIONS (2021)

添加到收藏夹

Review Endocrinology & Metabolism

The Hypothalamus-pituitary-adrenocortical Response to Critical Illness: A Concept in Need of Revision

Lies Langouche, Arno Teblick, Jan Gunst, Greet Van den Berghe

Summary: Based on recent insights, the classical concept of an activated hypothalamus-pituitary-adrenocortical axis in response to critical illness is in need of revision. Peripheral adaptations play a more significant role in maintaining increased systemic cortisol availability and action in response to critical illness than centrally activated cortisol production and secretion. These adaptations include suppressed cortisol metabolism, alterations in expression of certain proteins, and negative feedback inhibition at the pituitary level. Prolonged critical illness may lead to central adrenal insufficiency.

ENDOCRINE REVIEWS (2023)

添加到收藏夹

Review Medical Laboratory Technology

Perinatal presepsin assessment: a new sepsis diagnostic tool?

Valentina Botondi, Ebe D'Adamo, Mario Plebani, Oriana Trubiani, Marika Perrotta, Laura Di Ricco, Cynzia Spagnuolo, Sara De Sanctis, Elisabetta Barbante, Maria Chiara Strozzi, Antonio Maconi, Francesca Gazzolo, Marta Betti, Annalisa Roveta, Gabriella Levantini, Diego Gazzolo

Summary: Perinatal sepsis is a medical emergency with debated possibilities of early diagnosis. The new biomarker Presepsin (P-SEP) shows promise in early detection of sepsis.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

添加到收藏夹

Article Environmental Studies

Towards a care perspective on waste: A new direction in discard studies

Justin Chun-Him Lau

Summary: This article examines the development and theoretical orientation of waste scholarship in discard studies. It argues that current theoretical framings of waste tend to overlook the management of discarded objects and instead focus on the potential value generation or transformation of waste. Drawing inspiration from feminist science and technology studies, the article suggests that incorporating the analytical lens of care can further waste studies and inspire a politics of inclusion and the temporality of slowness.

ENVIRONMENT AND PLANNING C-POLITICS AND SPACE (2022)

添加到收藏夹

Article Agronomy

A new direction for phytosanitary risk management

Charles Yoe, Robert Griffin, Stephanie Bloem

Summary: The history of phytosanitary risk management initially focused on trade restrictive measures at ports-of-entry, but evolved towards trade liberalization with the introduction of the SPS Agreement and IPPC system approaches. The future of international trade lies in an integrated-holistic approach, merging current risk management silos and enhancing collaboration between stakeholders for increased trade efficiency and reduced costs.

CROP PROTECTION (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeted Mitochondrial Epigenetics: A New Direction in Alzheimer's Disease Treatment

Ying Song, Xin-Yi Zhu, Xiao-Min Zhang, He Xiong

Summary: This review discusses the close relationship between mitochondrial epigenetic alterations and Alzheimer's disease (AD). It highlights the disruption of mitochondrial DNA methylation and demethylation as a key factor in damaging mitochondrial function and hindering mitochondrial biogenesis. Additionally, it explores the role of mitochondrial noncoding RNA modifications and post-translational modifications in neurodegenerative diseases and their connection to AD. The review also provides a comprehensive summary of therapeutic approaches targeting mitochondrial epigenetics, including folic acid supplementation, mitochondrial-targeting antioxidants, and targeted ubiquitin-specific proteases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Chemistry, Analytical

A New Direction in Microfluidics: Printed Porous Materials

Hanno Evard, Hans Priks, Indrek Saar, Heili Aavola, Tarmo Tamm, Ivo Leito

Summary: The feasibility of a new direction in microfluidics was studied by demonstrating a set of new methods to fabricate microfluidic systems in this work. Different porous materials and printing methods were used to create the necessary patterns, and all three approaches were found to be suitable for microfluidics applications.

MICROMACHINES (2021)

添加到收藏夹

Article Medicine, General & Internal

APPRAISE-AI Tool for Quantitative Evaluation of AI Studies for Clinical Decision Support

Jethro C. C. Kwong, Adree Khondker, Katherine Lajkosz, Matthew B. A. Mcdermott, Xavier Borrat Frigola, Melissa D. Mccradden, Muhammad Mamdani, Girish S. Kulkarni, Alistair E. W. Johnson

Summary: In this quality improvement study, the APPRAISE-AI tool demonstrated strong interrater and intrarater reliability and correlated well with several study quality measures. This tool may provide a quantitative approach for investigators, reviewers, editors, and funding organizations to compare the research quality across AI studies for clinical decision support.

JAMA NETWORK OPEN (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway

Annette Ives, Didier Le Roy, Charlotte Theroude, Juergen Bernhagen, Thierry Roger, Thierry Calandra

Summary: The cytokine MIF plays a chemokine-like role in promoting the migration of dendritic cells (DCs) by activating the Src/PI3K signaling pathway and myosin II complexes. MIF contributes to the recruitment of DCs to draining lymph nodes through autocrine and paracrine activities acting via CD74. These findings indicate that MIF is crucial for DC motility and trafficking.

FASEB JOURNAL (2021)

添加到收藏夹

Review Infectious Diseases

Impact of the timeliness of antibiotic therapy on the outcome of patients with sepsis and septic shock

Sandra A. Asner, Florian Desgranges, Irene T. Schrijver, Thierry Calandra

Summary: The study reviewed the impact of the timeliness of antibiotic therapy on the outcome of patients with sepsis or septic shock. It found that early administration of antibiotic therapy was associated with patient outcome, but there were significant differences in antibiotic therapy time thresholds across studies and no robust time thresholds emerged.

JOURNAL OF INFECTION (2021)

添加到收藏夹

Article Infectious Diseases

High-dimensional immune phenotyping of blood cells by mass cytometry in patients infected with hepatitis C virus

Jacobus Herderschee, Tytti Heinonen, Craig Fenwick, Irene T. Schrijver, Khalid Ohmiti, Darius Moradpour, Matthias Cavassini, Giuseppe Pantaleo, Thierry Roger, Thierry Calandra

Summary: Chronic hepatitis C virus (HCV) and HCV/HIV infections have profound and durable effects on immune homeostasis, which persist even after treatment with direct-acting antivirals (DAA).

CLINICAL MICROBIOLOGY AND INFECTION (2022)

添加到收藏夹

Letter Infectious Diseases

Low neutralizing antibody titers after asymptomatic or non-severe SARS-CoV-2 infection over a 6-month assessment period

C. Lazor-Blanchet, P. Zygoura, U. Dafni, F. Lamoth, Z. Tsourti, M. A. Lobritz, J. Regina, B. Grandbastien, C. Fenwick, G. Pantaleo, T. Calandra, S. Meylan

JOURNAL OF INFECTION (2022)

添加到收藏夹

Article Critical Care Medicine

High levels of monocytic myeloid-derived suppressor cells are associated with favorable outcome in patients with pneumonia and sepsis with multi-organ failure

Irene T. Schrijver, Eleni Karakike, Charlotte Theroude, Petra Baumgartner, Alexandre Harari, Evangelos J. Giamarellos-Bourboulis, Thierry Calandra, Thierry Roger

Summary: This is the first study to associate high levels of M-MDSCs with improved survival in sepsis patients.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2022)

添加到收藏夹

Correction Oncology

Infectious complications of targeted drugs and biotherapies in acute leukemia. Clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the International Immunocompromised Host Society (ICHS) and the European Leukemia Net (ELN) (Apr, 10.1038/s41375-022-01556-7, 2022)

Georg Maschmeyer, Lars Bullinger, Carolina Garcia-Vidal, Raoul Herbrecht, Johan Maertens, Pierantonio Menna, Livio Pagano, Anne Thiebaut-Bertrand, Thierry Calandra

LEUKEMIA (2022)

添加到收藏夹

Review Oncology

Infectious complications of targeted drugs and biotherapies in acute leukemia. Clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the International Immunocompromised Host Society (ICHS) and the European Leukemia Net (ELN)

Georg Maschmeyer, Lars Bullinger, Carolina Garcia-Vidal, Raoul Herbrecht, Johan Maertens, Pierantonio Menna, Livio Pagano, Anne Thiebaut-Bertrand, Thierry Calandra

Summary: The 9th web-based European Conference on Infections in Leukemia (ECIL-9) reviewed the risk of infections and febrile neutropenia associated with newer immunotherapeutic agents and molecular targeted drugs for the treatment of AML and ALL. Evidence-based recommendations were developed and discussed for prevention and management of infectious complications, as well as drug-drug interactions.

LEUKEMIA (2022)

添加到收藏夹

Editorial Material Immunology

COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions

Irene T. Schrijver, Charlotte Theroude, Nikolaos Antonakos, Jean Regina, Didier Le Roy, Pierre-Alexandre Bart, Jean-Daniel Chiche, Matthieu Perreau, Giuseppe Pantaleo, Thierry Calandra, Thierry Roger

EUROPEAN JOURNAL OF IMMUNOLOGY (2022)

添加到收藏夹

Letter Infectious Diseases

Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, non-neutropenic, adult patients: An update including COVID-19 data

Matteo Bassetti, Valentina Zuccaro, Erika Asperges, Luigia Scudeller, Daniele Roberto Giacobbe

JOURNAL OF INFECTION (2022)

添加到收藏夹

Review Dermatology

Performance of existing clinical scores and laboratory tests for the diagnosis of invasive candidiasis in critically ill, nonneutropenic, adult patients: A systematic review with qualitative evidence synthesis

Daniele Roberto Giacobbe, Erika Asperges, Andrea Cortegiani, Cecilia Grecchi, Chiara Rebuffi, Valentina Zuccaro, Luigia Scudeller, Matteo Bassetti

Summary: This systematic review summarizes the diagnostic performance of clinical scores and laboratory tests for invasive candidiasis (IC) in critically ill, nonneutropenic adult patients in the Intensive Care Unit (ICU). Clinical scores consistently showed a high negative predictive value (NPV) and a low positive predictive value (PPV), while fungal antigen-based biomarkers retained a high NPV similar to clinical scores with a higher PPV but with heterogeneity across studies.

MYCOSES (2022)

添加到收藏夹

Article Immunology

Κey Role of Early Source Control in Candidemic Patients With Sepsis or Septic Shock

Matthaios Papadimitriou-Olivgeris, Julien Battistolo, Julien Poissy, Alix Coste, Pierre-Yves Bochud, Thierry Calandra, Laurence Senn, Frederic Lamoth

Summary: This study analyzed the predictors of mortality in patients with candidemia and found that early source control, particularly vascular catheter removal, was a key determinant of outcome in patients with sepsis or septic shock.

OPEN FORUM INFECTIOUS DISEASES (2022)

添加到收藏夹

Article Infectious Diseases

National Early Warning Score (NEWS) Outperforms Quick Sepsis-Related Organ Failure (qSOFA) Score for Early Detection of Sepsis in the Emergency Department

Dimitri Durr, Tapio Niemi, Jeremie Despraz, Selin Tusgul, Fabrice Dami, Rachid Akrour, Pierre-Nicolas Carron, Marie-Annick Le Pogam, Thierry Calandra, Sylvain Meylan

Summary: In emergency department patients with suspected sepsis, NEWS score had higher sensitivity while qSOFA score had higher specificity and positive predictive values.

ANTIBIOTICS-BASEL (2022)

添加到收藏夹

Article Medicine, General & Internal

ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol

Antigone Kotsaki, Peter Pickkers, Michael Bauer, Thierry Calandra, Mihaela Lupse, W. Joost Wiersinga, Sylvain Meylan, Frank Bloos, Tom van der Poll, Marleen A. Slim, Niels van Mourik, Marcella C. A. Muller, Lonneke van Vught, Alexander P. J. Vlaar, Aline de Nooijer, Lieke Bakkerus, Sebastian Weis, Nikolaos Antonakos, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis

Summary: This study aims to investigate the efficacy of precision immunotherapy on sepsis patients, focusing on the phenotypes of MALS and immunoparalysis. The study utilizes a randomized placebo-controlled double-blind design and stratifies patients using biomarkers. The results will be published in peer-reviewed journals.

BMJ OPEN (2022)

添加到收藏夹

Article Respiratory System

Pulmonary aspergillosis: diagnosis and treatment

Frederic Lamoth, Thierry Calandra

Summary: Aspergillus species are the most common cause of fungal infections of the lungs, including invasive pulmonary aspergillosis and chronic pulmonary aspergillosis. Invasive pulmonary aspergillosis primarily affects immunocompromised individuals, while chronic pulmonary aspergillosis primarily affects patients with pre-existing lung lesions. The diagnosis and management of pulmonary aspergillosis are both complex.

EUROPEAN RESPIRATORY REVIEW (2022)

添加到收藏夹

Review Microbiology

What Is New in Pulmonary Mucormycosis?

Francois Danion, Anne Coste, Coralie Le Hyaric, Clea Melenotte, Frederic Lamoth, Thierry Calandra, Dea Garcia-Hermoso, Vishukumar Aimanianda, Fanny Lanternier, Olivier Lortholary

Summary: Mucormycosis is a rare and life-threatening fungal infection caused by molds of the order Mucorales. It mainly affects the lungs, following the rhino-orbito-cerebral (ROC) areas and the skin. Risk factors for pulmonary mucormycosis (PM) include hematological malignancies and solid organ transplantation, while ROC infections are commonly associated with diabetes mellitus. The diagnosis of PM relies on CT scans, cultures, PCR tests, and histology, and treatment involves liposomal amphotericin B as the first-line therapy.

JOURNAL OF FUNGI (2023)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.