Epipolythiodiketopiperazine Alkaloids: Total Syntheses and Biological Activities

Structure, Bioactivity and Synthesis of Natural Products with Hexahydropyrrolo[2,3-b]indole

(2011) Pau Ruiz-Sanchis et al.   CHEMISTRY-A EUROPEAN JOURNAL

Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation

(2010) Yuou Teng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12′-Dideoxychetracin A

(2010) Justin Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Chaetocin and its Analogues: Their Histone Methyltransferase G9a Inhibitory Activity

(2010) Eriko Iwasa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereocontrolled and Versatile Total Synthesis of Bispyrrolidinoindoline Diketopiperazine Alkaloids: Structural Revision of the Fungal Isolate (+)-Asperdimin

(2009) Carlos Pérez-Balado et al.   CHEMISTRY-A EUROPEAN JOURNAL

Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1α (HIF-1α) and p300 by a Zinc Ejection Mechanism

(2009) Kristina M. Cook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Inhibition of Hypoxia-Inducible Transcription Factor Complex with Designed Dimeric Epidithiodiketopiperazine

(2009) Katherine M. Block et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-11,11'-Dideoxyverticillin A

(2009) J. Kim et al.   SCIENCE

Concise Total Synthesis of (+)-WIN 64821 and (−)-Ditryptophenaline

(2008) Mohammad Movassaghi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Anticancer Agent Chaetocin Is a Competitive Substrate and Inhibitor of Thioredoxin Reductase

(2008) Jennifer D. Tibodeau et al.   ANTIOXIDANTS & REDOX SIGNALING

Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells

(2008) Hideo Watanabe et al.   Cancer Cell International

Expedient Total Syntheses of WIN 64745 and WIN 64821

(2008) Carlos Pérez-Balado et al.   ORGANIC LETTERS

Downregulation of Histone H3 Lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells

(2008) Yutaka Kondo et al.   PLoS One