Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
出版年份 2016 全文链接
标题
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
作者
关键词
Methylome, Lysine methylation, Histone methyltransferase, Histone demethylase, Clinical trial, Methyltransferase inhibitors, Demethylase inhibitors, Epigenetics, Histone modifications
出版物
Clinical Epigenetics
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2016-05-22
DOI
10.1186/s13148-016-0223-4
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation
- (2016) Eric Metzger et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform
- (2016) Tobias Wagner et al. NUCLEIC ACIDS RESEARCH
- Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation
- (2016) Eric Metzger et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Advances in the development of histone lysine demethylase inhibitors
- (2015) Tamara Maes et al. CURRENT OPINION IN PHARMACOLOGY
- The promise and peril of chemical probes
- (2015) Cheryl H Arrowsmith et al. Nature Chemical Biology
- SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
- (2015) Kimberly H Kim et al. NATURE MEDICINE
- Targeting histone lysine methylation in cancer
- (2015) John McGrath et al. PHARMACOLOGY & THERAPEUTICS
- Epigenetic regulation by histone demethylases in hypoxia
- (2015) Rebecca L Hancock et al. Epigenomics
- The histone code reader SPIN1 controls RET signaling in liposarcoma
- (2015) Henriette Franz et al. Oncotarget
- KDM5C Is Overexpressed in Prostate Cancer and Is a Prognostic Marker for Prostate-Specific Antigen-Relapse Following Radical Prostatectomy
- (2014) Johannes Stein et al. AMERICAN JOURNAL OF PATHOLOGY
- Development and classes of epigenetic drugs for cancer
- (2014) Dashyant Dhanak et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor
- (2014) Aravind Basavapathruni et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- SnapShot: Histone Modifications
- (2014) He Huang et al. CELL
- Histone variants: key players of chromatin
- (2014) Burcu Biterge et al. CELL AND TISSUE RESEARCH
- EZH2 Inhibitor Efficacy in Non-Hodgkin’s Lymphoma Does Not Require Suppression of H3K27 Monomethylation
- (2014) William D. Bradley et al. CHEMISTRY & BIOLOGY
- Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation
- (2014) Tobias Wagner et al. ChemMedChem
- Cytostatic and Apoptotic Effects of DNMT and HDAC Inhibitors in Endometrial Cancer Cells
- (2014) Shaohua Xu et al. CURRENT PHARMACEUTICAL DESIGN
- 212 Novel anti-tumor activity of targeted LSD1 inhibition by GSK2879552
- (2014) H. Mohammad et al. EUROPEAN JOURNAL OF CANCER
- Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells
- (2014) W Fiskus et al. LEUKEMIA
- microRNA-124 inhibits proliferation and induces apoptosis by directly repressing EZH2 in gastric cancer
- (2014) Liming Xie et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
- (2014) S. K. Knutson et al. MOLECULAR CANCER THERAPEUTICS
- Targeting bromodomains: epigenetic readers of lysine acetylation
- (2014) Panagis Filippakopoulos et al. NATURE REVIEWS DRUG DISCOVERY
- Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation
- (2014) Cheng Dong et al. IUCrJ
- Bromo-deaza-SAH: A potent and selective DOT1L inhibitor
- (2013) Wenyu Yu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
- (2013) S. R. Daigle et al. BLOOD
- Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells
- (2013) Shauna N. Vasilatos et al. CARCINOGENESIS
- Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes
- (2013) Geeta J. Narlikar et al. CELL
- Identification of EZH2 and EZH1 Small Molecule Inhibitors with Selective Impact on Diffuse Large B Cell Lymphoma Cell Growth
- (2013) Shivani Garapaty-Rao et al. CHEMISTRY & BIOLOGY
- DNA methylation and methylcytosine oxidation in cell fate decisions
- (2013) Kian Peng Koh et al. CURRENT OPINION IN CELL BIOLOGY
- A Medicinal Chemistry Perspective for Targeting Histone H3 Lysine-79 Methyltransferase DOT1L
- (2013) Justin L. Anglin et al. JOURNAL OF MEDICINAL CHEMISTRY
- NF-YA Underlies EZH2 Upregulation and Is Essential for Proliferation of Human Epithelial Ovarian Cancer Cells
- (2013) Azat Garipov et al. MOLECULAR CANCER RESEARCH
- Chromatin proteins and modifications as drug targets
- (2013) Kristian Helin et al. NATURE
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
- (2013) Cigall Kadoch et al. NATURE GENETICS
- Regulation of nucleosome dynamics by histone modifications
- (2013) Gabriel E Zentner et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- H1 histones: current perspectives and challenges
- (2013) S. W. Harshman et al. NUCLEIC ACIDS RESEARCH
- Genomic Deregulation of the E2F/Rb Pathway Leads to Activation of the Oncogene EZH2 in Small Cell Lung Cancer
- (2013) Bradley P. Coe et al. PLoS One
- Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations
- (2013) Hong Wu et al. PLoS One
- Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
- (2013) S. K. Knutson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases
- (2013) Zhanxin Wang et al. QUARTERLY REVIEWS OF BIOPHYSICS
- (Poly)Combing the Pediatric Cancer Genome for Answers
- (2013) M. A. Morgan et al. SCIENCE
- SET for life: biochemical activities and biological functions of SET domain-containing proteins
- (2013) Hans-Martin Herz et al. TRENDS IN BIOCHEMICAL SCIENCES
- Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L
- (2013) Lisheng Deng et al. MedChemComm
- Dot1-Dependent Histone H3K79 Methylation Promotes Activation of the Mek1 Meiotic Checkpoint Effector Kinase by Regulating the Hop1 Adaptor
- (2013) David Ontoso et al. PLoS Genetics
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
- (2012) William J. Harris et al. CANCER CELL
- The BRAFV600E causes widespread alterations in gene methylation in the genome of melanoma cells
- (2012) Peng Hou et al. CELL CYCLE
- Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L
- (2012) Aravind Basavapathruni et al. Chemical Biology & Drug Design
- Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly
- (2012) Jun-ichirou Ohzeki et al. EMBO JOURNAL
- Loss of PBRM1 expression is associated with renal cell carcinoma progression
- (2012) Rafal Pawłowski et al. INTERNATIONAL JOURNAL OF CANCER
- Disordered epigenetic regulation in MLL-related leukemia
- (2012) Yue Zhang et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Down-Regulation of the miR-25 and miR-30d Contributes to the Development of Anaplastic Thyroid Carcinoma Targeting the Polycomb Protein EZH2
- (2012) Francesco Esposito et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Synthesis and Structure–Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L
- (2012) Justin L. Anglin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l
- (2012) L Chen et al. LEUKEMIA
- MicroRNA-98 and microRNA-214 post-transcriptionally regulate enhancer of zeste homolog 2 and inhibit migration and invasion in human esophageal squamous cell carcinoma
- (2012) Sheng-Dong Huang et al. Molecular Cancer
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
- (2012) Tino Schenk et al. NATURE MEDICINE
- Epigenetic protein families: a new frontier for drug discovery
- (2012) Cheryl H. Arrowsmith et al. NATURE REVIEWS DRUG DISCOVERY
- Histone methylation: a dynamic mark in health, disease and inheritance
- (2012) Eric L. Greer et al. NATURE REVIEWS GENETICS
- Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer
- (2012) A. H. Shain et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
- (2012) W. Qi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2
- (2012) Sharad K. Verma et al. ACS Medicinal Chemistry Letters
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2012) Wenyu Yu et al. Nature Communications
- Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors
- (2011) Hanae Benelkebir et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
- (2011) S. Y. Jo et al. BLOOD
- DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
- (2011) A. T. Nguyen et al. BLOOD
- Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells
- (2011) Yi Huang et al. BREAST CANCER RESEARCH AND TREATMENT
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
- (2011) Masashi Takawa et al. CANCER SCIENCE
- Essential role of DOT1L in maintaining normal adult hematopoiesis
- (2011) Anh T Nguyen et al. CELL RESEARCH
- Regulation of chromatin by histone modifications
- (2011) Andrew J Bannister et al. CELL RESEARCH
- ATP-dependent chromatin remodeling: genetics, genomics and mechanisms
- (2011) Diana C Hargreaves et al. CELL RESEARCH
- DNA hypermethylation as a chemotherapy target
- (2011) Juan Ren et al. CELLULAR SIGNALLING
- Chemogenetic Analysis of Human Protein Methyltransferases
- (2011) Victoria M. Richon et al. Chemical Biology & Drug Design
- The diverse functions of Dot1 and H3K79 methylation
- (2011) A. T. Nguyen et al. GENES & DEVELOPMENT
- Methylation-mediated regulation of E2F1 in DNA damage-induced cell death
- (2011) Qi Xie et al. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies
- (2011) Yuan Yao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Histone Chaperones: Modulators of Chromatin Marks
- (2011) Nikita Avvakumov et al. MOLECULAR CELL
- The Polycomb complex PRC2 and its mark in life
- (2011) Raphaël Margueron et al. NATURE
- The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
- (2011) Craig J. Ceol et al. NATURE
- ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome
- (2011) Shigeki Iwase et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- MEK–ERK pathway regulates EZH2 overexpression in association with aggressive breast cancer subtypes
- (2011) S Fujii et al. ONCOGENE
- Early mammalian erythropoiesis requires the Dot1L methyltransferase
- (2010) Y. Feng et al. BLOOD
- Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma
- (2010) Nina Wagener et al. BMC CANCER
- Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development
- (2010) T. Bianco-Miotto et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes
- (2010) M.-J. Chang et al. CANCER RESEARCH
- The Language of Histone Crosstalk
- (2010) Jung-Shin Lee et al. CELL
- 178 Preclinical characterization of 4SC-202, a novel isotype specific HDAC inhibitor
- (2010) S.W. Henning et al. EJC SUPPLEMENTS
- SET7/9 mediated methylation of non-histone proteins in mammalian cells
- (2010) Sriharsa Pradhan et al. Epigenetics
- Epigenetic regulation of cancer growth by histone demethylases
- (2010) Soyoung Lim et al. INTERNATIONAL JOURNAL OF CANCER
- Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2
- (2010) Claudia Binda et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation
- (2010) Champak Chatterjee et al. Nature Chemical Biology
- Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
- (2010) Gorica Nikoloski et al. NATURE GENETICS
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
- (2010) C. J. Sneeringer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting epigenetic modifiers: Inhibitors of histone methyltransferases
- (2010) Elisabeth-Maria Bissinger et al. MedChemComm
- Chromatin Higher-order Structure and Dynamics
- (2010) C. L. Woodcock et al. Cold Spring Harbor Perspectives in Biology
- Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study
- (2009) B. V. Balgobind et al. BLOOD
- Long noncoding RNAs: functional surprises from the RNA world
- (2009) J. E. Wilusz et al. GENES & DEVELOPMENT
- The Dot1 Histone Methyltransferase and the Rad9 Checkpoint Adaptor Contribute to Cohesin-Dependent Double-Strand Break Repair by Sister Chromatid Recombination in Saccharomyces cerevisiae
- (2009) F. Conde et al. GENETICS
- The molecular biology of mixed lineage leukemia
- (2009) R. K. Slany HAEMATOLOGICA
- In VivoResidue-specific Histone Methylation Dynamics
- (2009) Barry M. Zee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Novel Mammalian Flavin-dependent Histone Demethylase
- (2009) Aristotele Karytinos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Current Prescription Patterns and Safety Profile of Irreversible Monoamine Oxidase Inhibitors
- (2009) Kenneth I. Shulman et al. JOURNAL OF CLINICAL PSYCHIATRY
- Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models
- (2009) T. M. Pitts et al. MOLECULAR CANCER THERAPEUTICS
- DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
- (2009) T. B. Miranda et al. MOLECULAR CANCER THERAPEUTICS
- Protein methyltransferases as a target class for drug discovery
- (2009) Robert A. Copeland et al. NATURE REVIEWS DRUG DISCOVERY
- Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma
- (2009) M. Berdasco et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia
- (2009) Dorothee Mueller et al. PLOS BIOLOGY
- H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias
- (2008) Andrei V. Krivtsov et al. CANCER CELL
- Loss of Histone H4K20 Trimethylation Occurs in Preneoplasia and Influences Prognosis of Non-Small Cell Lung Cancer
- (2008) A. Van Den Broeck et al. CLINICAL CANCER RESEARCH
- The emerging field of dynamic lysine methylation of non-histone proteins
- (2008) Jing Huang et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
- (2008) Pedro P. Medina et al. HUMAN MUTATION
- Cancer treatment of the future: Inhibitors of histone methyltransferases
- (2008) Astrid Spannhoff et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Roles of the EZH2 histone methyltransferase in cancer epigenetics
- (2008) Jeffrey A. Simon et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation
- (2008) Robert K. McGinty et al. NATURE
- The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
- (2008) Jing Wang et al. NATURE GENETICS
- Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
- (2008) S. Varambally et al. SCIENCE
- The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure
- (2008) Brendan Jones et al. PLoS Genetics
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More