The involvement of microglia in Alzheimer's disease: a new dog in the fight

Plaque-dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer's disease mouse model

(2018) Monika Plescher et al.   GLIA

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

(2018) James C. Cronk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

(2018) Harald Lund et al.   NATURE IMMUNOLOGY

Microglia-targeted candidates push the Alzheimer drug envelope

(2018) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Modelling microglial function with induced pluripotent stem cells: an update

(2018) Jennifer M. Pocock et al.   NATURE REVIEWS NEUROSCIENCE

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

(2018) C.Y. Daniel Lee et al.   NEURON

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

(2018) Stephen D. Skaper et al.   Frontiers in Cellular Neuroscience

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Pfizer abandons research into Alzheimer’s and Parkinson’s diseases

(2018) Nigel Hawkes   BMJ-British Medical Journal

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

(2018) Brad A. Friedman et al.   Cell Reports

Pfizer abandons research into Alzheimer’s and Parkinson’s diseases

(2018) Nigel Hawkes   BMJ-British Medical Journal

Gene Therapy for Neuropathic Pain through siRNA-IRF5 Gene Delivery with Homing Peptides to Microglia

(2018) Tomoya Terashima et al.   Molecular Therapy-Nucleic Acids

Microglia heterogeneity along a spatio-temporal axis: More questions than answers

(2018) Aymeric Silvin et al.   GLIA

Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils

(2018) Angela Marie Floden et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

(2018) Pablo Garcia-Reitboeck et al.   Cell Reports

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

(2017) Petra Füger et al.   NATURE NEUROSCIENCE

Microglial Interferon Signaling and White Matter

(2017) Ashley McDonough et al.   NEUROCHEMICAL RESEARCH

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

(2017) Dimitry Ofengeim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

(2017) Aleksandra Deczkowska et al.   Nature Communications

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

GM-CSF Upregulated in Rheumatoid Arthritis Reverses Cognitive Impairment and Amyloidosis in Alzheimer Mice

(2017) Tim D. Boyd et al.   JOURNAL OF ALZHEIMERS DISEASE

Immunosenescence of microglia and macrophages: impact on the ageing central nervous system

(2016) Khalil S. Rawji et al.   BRAIN

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Type-1 interferons contribute to the neuroinflammatory response and disease progression of the MPTP mouse model of Parkinson's disease

(2016) Bevan S. Main et al.   GLIA

Targeting microglia for the treatment of Alzheimer's Disease

(2016) Paul D. Wes et al.   GLIA

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor

(2016) Thomas Möller et al.   GLIA

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Low-dielectric-constant polyimide aerogel composite films with low water uptake

(2016) Jinyoung Kim et al.   POLYMER JOURNAL

Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function

(2016) Maria I. Fonseca et al.   PLoS One

GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP

(2015) Vijay K Ramanan et al.   BRAIN

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

PLAID: a Syndrome of Complex Patterns of Disease and Unique Phenotypes

(2015) Joshua D. Milner   JOURNAL OF CLINICAL IMMUNOLOGY

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation

(2015) Jonathan D. Cherry et al.   Journal of Neuroinflammation

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

What does it take to produce a breakthrough drug?

(2015) Dirk Calcoen et al.   NATURE REVIEWS DRUG DISCOVERY

What happens to microglial TREM2 in Alzheimer’s disease: Immunoregulatory turned into immunopathogenic?

(2015) L.-F. Lue et al.   NEUROSCIENCE

A combined cumulative threshold spectra and digital reconstruction analysis reveal structural alterations of microglia within the prefrontal cortex following low-dose LPS administration

(2015) R. Kongsui et al.   NEUROSCIENCE

CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid

(2015) V. Porrini et al.   NEUROSCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

(2015) Adam D Bachstetter et al.   Acta Neuropathologica Communications

Dynamic structural remodelling of microglia in health and disease: A review of the models, the signals and the mechanisms

(2014) F. Rohan Walker et al.   BRAIN BEHAVIOR AND IMMUNITY

CR1 in Alzheimer's Disease

(2014) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Innate Immunity and Neuroinflammation

(2013) Abhishek Shastri et al.   MEDIATORS OF INFLAMMATION

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease

(2013) Juliet M. Taylor et al.   NEUROBIOLOGY OF AGING

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

CD33-related siglecs as potential modulators of inflammatory responses

(2012) Paul R. Crocker et al.   Annals of the New York Academy of Sciences

Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

(2012) Flavia Antonucci et al.   EMBO JOURNAL

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’

(2012) Guy C. Brown et al.   TRENDS IN BIOCHEMICAL SCIENCES

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice

(2011) T Kiyota et al.   GENE THERAPY

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia

(2011) Urte Neniskyte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Ectosomes as modulators of inflammation and immunity

(2010) S. Sadallah et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice

(2010) Tomomi Kiyota et al.   FASEB JOURNAL

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

(2010) eMalick G. Njie et al.   NEUROBIOLOGY OF AGING

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factor  Signaling during Peripheral Organ Inflammation

(2009) C. D'Mello et al.   JOURNAL OF NEUROSCIENCE

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

(2009) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

(2008) Sanjay W. Pimplikar   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY