Review
Pharmacology & Pharmacy
Maria N. Navarro, Manuel M. Gomez de las Heras, Maria Mittelbrunn
Summary: Immune metabolism is closely related to cellular functions such as energy metabolism and inflammation. The manipulation of NAD(+) availability through pharmacological compounds can have immune-modulatory properties in inflammation, offering opportunities for therapeutic intervention in inflammatory disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Virology
Eman Teer, Nyasha C. Mukonowenzou, M. Faadiel Essop
Summary: This article explores the relationship between immune metabolism and HIV pathogenesis, revealing that metabolic reprogramming plays a crucial role in HIV-1 pathogenesis. The shift from quiescent immune cells to activation leads to metabolic perturbations that drive immune cell dysfunction and altered phenotype.
Article
Cell Biology
Yajing Fu, Zining Zhang, Zhijun Yang, Yongjun Jiang, Xiaoxu Han, Junjie Xu, Zhenxing Chu, Haibo Ding, Sijia He, Hong Shang
Summary: Research reveals an accumulation of CD27(-) CD38(+) B cell subset during early HIV infection, which may contribute to disease progression. Individuals with higher proportions of these B cells tend to progress rapidly to chronic infection stage.
Review
Immunology
Valentina Audrito, Vincenzo Gianluca Messana, Lorenzo Brandimarte, Silvia Deaglio
Summary: NADome refers to the complex network of enzymes that regulate the synthesis or degradation of NAD, both intracellularly and extracellularly, as well as the receptors involved. Recent studies have shown that NAD has biological activity outside of cells, potentially linked to immunomodulation and non-enzymatic activities. Extracellular NAD can trigger inflammatory responses, similar to ATP.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Fabio Morandi, Alberto Leonardo Horenstein, Fabio Malavasi
Summary: NAD(+) is a crucial molecule in metabolic processes, with CD38 playing a key role in immunosuppression in various types of tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Maura Manion, Afroditi Boulougoura, Nuha Naqvi, Silvia Lucena Lage, Elizabeth Richards, Christopher Grivas, Elizabeth Laidlaw, Safia Kuriakose, Ana M. Ortega-Villa, Saber Tadros, Gregg Roby, Adam Rupert, France Galindo, Megan Anderson, Alice Pau, George Deepe, Virginia Sheikh, Irini Sereti
Summary: Limited data exists on the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with HIV in the combination antiretroviral era. Immunological analysis was performed on 10 cases of histoplasmosis, 4 of which developed histoplasmosis IRIS. Histoplasmosis IRIS patients exhibited a significant polyfunctional cytokine response to histoplasma antigen.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Mayer, Marc Altvater, Judith Schenz, Rawa Arif, Matthias Karck, Florian Leuschner, Markus A. Weigand, Florian Uhle, Christoph Lichtenstern
Summary: Cardiopulmonary bypass can cause systemic inflammation, leading to a shift in monocyte metabolism from oxidative phosphorylation to aerobic glycolysis, which is associated with energy-demanding and proinflammatory processes. Interestingly, altered metabolism in monocytes can be observed in patients undergoing cardiac surgery even before any surgical procedure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rodney K. Rousseau, Leah Szadkowski, Colin M. Kovacs, Michael F. Saikali, Rabea Nadeem, Fat Malazogu, Sanja Huibner, Carolyn L. Cummins, Rupert Kaul, Sharon L. Walmsley
Summary: The study revealed that during long-term treated HIV infection, immunologic non-responders (INRs) show elevated CD8 activation and CD4 gut homing. Gut-focused interventions may be needed in the context of INRs, and CD8 activation could serve as a surrogate endpoint for clinical interventions.
Review
Biochemistry & Molecular Biology
Melinda S. Suchard, Dana M. Savulescu
Summary: During infection, macrophages undergo divergent pathways of metabolism and switch between oxidative phosphorylation and aerobic glycolysis, with potential therapeutic implications for infectious diseases like sepsis and COVID-19. Manipulation of nicotinamide pathways could correct deleterious immune responses.
Article
Fisheries
Lik-Ming Lau, Misato Kuga, Motohiko Sano, Goshi Kato
Summary: In this study, a murine cell line expressing ginbuna crucian carp (ginbuna) CD4-2 was established to develop an anti-CD4-2 monoclonal antibody. The developed antibody (D5) showed good reactivity to CD4-2-expressing cells and lymphocytes in ginbuna. Gene expression analysis and staining of sorted D5+ cells confirmed the lymphocyte identity of the CD4-2-expressing cells. Flow cytometry analysis revealed that ginbuna CD4+ lymphocyte population consists of two major subpopulations (CD4-1 SP and CD4-2 SP) and a minor subset (CD4 DP).
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Immunology
Quentin Le Hingrat, Irini Sereti, Alan L. Landay, Ivona Pandrea, Cristian Apetrei
Summary: CD4(+) T-cell depletion is a key feature of AIDS in both HIV and SIV infections, occurring early and being most significant at mucosal sites. The clinical outcome is associated with mucosal CD4(+) T-cell recovery during chronic infection, while immune activation and inflammation play critical roles in CD4(+) T-cell depletion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Javier Martinez-Sanz, Jorge Diaz-alvarez, Marta Rosas, Raquel Ron, Jose Antonio Iribarren, Enrique Bernal, Felix Gutierrez, Andres Ruiz Sancho, Noemi Cabello, Julian Olalla, Santiago Moreno, Sergio Serrano-Villar
Summary: The study suggests that a low CD4/CD8 ratio during HIV treatment is associated with immunosenescence. Data analysis shows that patients with a CD4/CD8 ratio less than 0.3 in the second year of ART have an increased risk of developing SNAEs in the next five years.
Article
Immunology
Tiffany R. Butterfield, David B. Hanna, Robert C. Kaplan, Xiaonan Xue, Jorge R. Kizer, Helen G. Durkin, Seble G. Kassaye, Marek Nowicki, Phyllis C. Tien, Elizabeth T. Topper, Michelle A. Floris-Moore, Kehmia Titanji, Margaret A. Fischl, Sonya Heath, Clovis S. Palmer, Alan L. Landay, Joshua J. Anzinger
Summary: This study investigated the glucose metabolism of CD4(+) T cells in HIV-positive women with and without diabetes mellitus. The results showed that HIV-positive women with diabetes mellitus had elevated CD4(+) T cell glucose metabolism, and treatment of diabetes mellitus may partially correct CD4(+) T cell metabolic dysfunction.
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Review
Immunology
Yannick Foerster, Lukas Sollfrank, Laura Rechtien, Thomas Harrer, Carola Berking, Michael Sticherling
Summary: This article describes three patients with bullous pemphigoid and concomitant HIV-1 infection. The patients received modern combined antiretroviral therapy and additional treatment based on the severity of their condition. All patients experienced significant improvement in their skin lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Gustavo Olvera-Garcia, Tania Aguilar-Garcia, Fany Gutierrez-Jasso, Ivan Imaz-Rosshandler, Claudia Rangel-Escareno, Lorena Orozco, Irma Aguilar-Delfin, Joel A. Vazquez-Perez, Joaquin Zuniga, Santiago Perez-Patrigeon, Enrique Espinosa
Article
Biotechnology & Applied Microbiology
Daniela Wuersch, Christopher E. Ormsby, Damaris P. Romero-Rodriguez, Gustavo Olvera-Garcia, Joaquin Zuniga, Wei Jiang, Santiago Perez-Patrigeon, Enrique Espinosa
Article
Immunology
Zhenwu Luo, Zhen Li, Lisa Martin, Zhuang Wan, Eric G. Meissner, Enrique Espinosa, Hao Wu, Xiaocong Yu, Pingfu Fu, Maria Anna Julia Westerink, J. Michael Kilby, Jennifer Wu, Lei Huang, Sonya L. Heath, Zihai Li, Wei Jiang
JOURNAL OF INFECTIOUS DISEASES
(2017)
Article
Immunology
Gustavo Olvera-Garcia, Enrique Espinosa, Scott F. Sieg, Michael M. Lederman
Article
Virology
Wei Jiang, Souheil-Antoine Younes, Nicholas T. Funderburg, Joseph C. Mudd, Enrique Espinosa, Miles P. Davenport, Denise C. Babineau, Scott F. Sieg, Michael M. Lederman
JOURNAL OF VIROLOGY
(2014)
Article
Multidisciplinary Sciences
Amayrani Abrego-Peredo, Hector Romero-Ramirez, Enrique Espinosa, Gabriela Lopez-Herrera, Fabio Garcia-Garcia, Monica Flores-Munoz, Claudia Sandoval-Montes, Juan Carlos Rodriguez-Alba
Article
Biology
Lucero A. Ramon-Luing, Ranferi Ocana-Guzman, Norma A. Tellez-Navarrete, Mario Preciado-Garcia, Damaris P. Romero-Rodriguez, Enrique Espinosa, Gustavo Reyes-Teran, Leslie Chavez-Galan
Summary: IRIS is an exacerbated immune response that can occur to HIV+ patients after initiating ART treatment. This study found that high levels of soluble TIM-3 and TNF-alpha could serve as biomarkers for IRIS.
Article
Biochemistry & Molecular Biology
Jocelyn C. Perez-Lara, Enrique Espinosa, Leopoldo Santos-Argumedo, Hector Romero-Ramirez, Gabriela Lopez-Herrera, Fabio Garcia-Garcia, Claudia Sandoval-Montes, Vianney Ortiz-Navarrete, Monica Flores-Munoz, Juan C. Rodriguez-Alba
Summary: CD38 is a transmembrane glycoprotein expressed by T-cells and may play a role in regulating immune activation cells in SLE patients. Studies have found correlations between CD38 and regulatory T-cells as well as immunosuppressive molecules, suggesting that CD38 deficiency could enhance autoimmunity development. Additionally, CD38 appears to be crucial in maintaining activated and proliferative Treg cells, potentially preventing SLE development through Treg cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyu Fu, Da Cheng, Zhenwu Luo, Sonya L. Heath, Ruth Adekunle, John E. McKinnon, Lisa Martin, Zizhang Sheng, Enrique Espinosa, Wei Jiang
Summary: Up to 20% of individuals with HIV fail to experience complete immune restoration after antiretroviral therapy (ART). A study found that anti-CD4 IgG autoantibodies deplete CD4 + T cells through antibody-dependent cytotoxicity in these individuals. The study also discovered that increased levels of lipopolysaccharide (LPS) in the blood and enhanced B cell expression of TLR2, TLR4, and MyD88 mRNA were associated with elevated plasma anti-CD4 IgG levels in PWH.
CELL AND BIOSCIENCE
(2023)