Mitochondrial Dysfunction in Type 2 Diabetes Mellitus: An Organ-Based Analysis

Repairing Mitochondrial Dysfunction in Disease

(2018) Vincenzo Sorrentino et al.   Annual Review of Pharmacology and Toxicology

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

(2018) Emily Tubbs et al.   DIABETES

Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals

(2018) Juraj Koska et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Base-Resolution Mapping Reveals Distinct m 1 A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts

(2017) Xiaoyu Li et al.   MOLECULAR CELL

Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress

(2017) Olli Matilainen et al.   TRENDS IN CELL BIOLOGY

The electrochemical transmission in I-Band segments of the mitochondrial reticulum

(2016) Keval D. Patel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

(2016) Qilong Wang et al.   DIABETES

Integrative analysis ofArabidopsis thalianatranscriptomics reveals intuitive splicing mechanism for circular RNA

(2016) Xiaoyong Sun et al.   FEBS LETTERS

Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity

(2016) Christof Angermueller et al.   NATURE METHODS

Endogenous microRNA sponges: evidence and controversy

(2016) Daniel W. Thomson et al.   NATURE REVIEWS GENETICS

CpG methylation patterns of human mitochondrial DNA

(2016) Baojing Liu et al.   Scientific Reports

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Increased Oxidative Stress and Mitochondrial Dysfunction in Zucker Diabetic Rat Liver and Brain

(2015) Haider Raza et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic HeartCLINICAL PERSPECTIVE

(2015) Rajaganapathi Jagannathan et al.   Circulation-Cardiovascular Genetics

The mitochondrial lncRNA ASncmtRNA-2 is induced in aging and replicative senescence in Endothelial Cells

(2015) Valentina Bianchessi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing

(2015) Michael B Clark et al.   NATURE METHODS

Mitochondrial epigenetics: an overlooked layer of regulation?

(2015) Monique G.P. van der Wijst et al.   TRENDS IN GENETICS

Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic HeartCLINICAL PERSPECTIVE

(2015) Rajaganapathi Jagannathan et al.   Circulation-Cardiovascular Genetics

Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling

(2014) Saisudha Koka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Stimulation of oxidative phosphorylation by calcium in cardiac mitochondria is not influenced by cAMP and PKA activity

(2014) Raul Covian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

(2014) David Montaigne et al.   CIRCULATION

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

(2014) R. X. Santos et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects

(2014) Mrittika Chattopadhyay et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Sequencing depth and coverage: key considerations in genomic analyses

(2014) David Sims et al.   NATURE REVIEWS GENETICS

Age-Related Mitochondrial DNA Depletion and the Impact on Pancreatic Beta Cell Function

(2014) Donna L. Nile et al.   PLoS One

Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals

(2013) Howard C. Masuoka et al.   Annals of the New York Academy of Sciences

Effect of Calcium on the Oxidative Phosphorylation Cascade in Skeletal Muscle Mitochondria

(2013) Brian Glancy et al.   BIOCHEMISTRY

Charting a dynamic DNA methylation landscape of the human genome

(2013) Michael J. Ziller et al.   NATURE

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Adverse Alterations in Mitochondrial Function Contribute to Type 2 Diabetes Mellitus–Related Endothelial Dysfunction in Humans

(2012) Tinoy J. Kizhakekuttu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

(2012) Subir K. Roy Chowdhury et al.   BRAIN

Nuclear miRNA Regulates the Mitochondrial Genome in the Heart

(2012) Samarjit Das et al.   CIRCULATION RESEARCH

GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice

(2012) C. G. Tocchetti et al.   DIABETES

Mitochondrial DNA Coding and Control Region Variants as Genetic Risk Factors for Type 2 Diabetes

(2012) C.-W. Liou et al.   DIABETES

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

(2012) Michael Volkmar et al.   EMBO JOURNAL

Physical Activity Is the Key Determinant of Skeletal Muscle Mitochondrial Function in Type 2 Diabetes

(2012) F. H. J. van Tienen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

Linking mitochondrial bioenergetics to insulin resistance via redox biology

(2012) Kelsey H. Fisher-Wellman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Altered Mitochondrial Dynamics Contributes to Endothelial Dysfunction in Diabetes Mellitus

(2011) Sherene M. Shenouda et al.   CIRCULATION

p53 Promotes Cardiac Dysfunction in Diabetic Mellitus Caused by Excessive Mitochondrial Respiration-Mediated Reactive Oxygen Species Generation and Lipid Accumulation

(2011) Hideo Nakamura et al.   Circulation-Heart Failure

Skeletal Muscle Mitochondrial Capacity and Insulin Resistance in Type 2 Diabetes

(2011) Sudip Bajpeyi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial bioenergetics is not impaired in nonobese subjects with type 2 diabetes mellitus

(2011) Mrittika Chattopadhyay et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction

(2010) A. Bravard et al.   DIABETES

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

(2010) R. Scott Rector et al.   JOURNAL OF HEPATOLOGY

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice

(2009) Takashi Yokota et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

(2009) Ethan J. Anderson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians

(2008) K. S. Park et al.   DIABETOLOGIA

An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)

(2008) V. K. Rakyan et al.   GENOME RESEARCH

Saturated Fatty Acids Inhibit Hepatic Insulin Action by Modulating Insulin Receptor Expression and Post-receptor Signalling

(2008) M. W. Ruddock et al.   JOURNAL OF BIOCHEMISTRY

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Short-Term Exercise Improves β-Cell Function and Insulin Resistance in Older People with Impaired Glucose Tolerance

(2007) Cathie J. Bloem et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM