Oncolytic Immunotherapy: Dying the Right Way is a Key to Eliciting Potent Antitumor Immunity

Reovirus Activates Human Dendritic Cells to Promote Innate Antitumor Immunity

(2014) Fiona Errington et al.   JOURNAL OF IMMUNOLOGY

Complementary Induction of Immunogenic Cell Death by Oncolytic Parvovirus H-1PV and Gemcitabine in Pancreatic Cancer

(2014) A. L. Angelova et al.   JOURNAL OF VIROLOGY

The Strength of the T Cell Response Against a Surrogate Tumor Antigen Induced by Oncolytic VSV Therapy Does Not Correlate With Tumor Control

(2014) Valérie Janelle et al.   MOLECULAR THERAPY

Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy

(2014) D. Zamarin et al.   Science Translational Medicine

Reovirus modulates autophagy during oncolysis of multiple myeloma

(2013) Chandini M. Thirukkumaran et al.   Autophagy

Hemagglutinin protein of measles virus induces apoptosis of HeLa cells via both extrinsic and intrinsic pathways

(2013) Changhua Yi et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans

(2013) C. J. Breitbach et al.   CANCER RESEARCH

Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments

(2013) H Inoue et al.   CELL DEATH AND DIFFERENTIATION

Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF-Coding Oncolytic Adenovirus

(2013) A. Kanerva et al.   CLINICAL CANCER RESEARCH

Targeting autophagy to enhance oncolytic virus-based cancer therapy

(2013) Songshu Meng et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages

(2013) Qiang Wang et al.   INTERNATIONAL IMMUNOLOGY

Influenza A Virus Proteins NS1 and Hemagglutinin Along with M2 Are Involved in Stimulation of Autophagy in Infected Cells

(2013) O. P. Zhirnov et al.   JOURNAL OF VIROLOGY

Oncolytic viruses as therapeutic cancer vaccines

(2013) David L Bartlett et al.   Molecular Cancer

Vaccinia Virus Induces Programmed Necrosis in Ovarian Cancer Cells

(2013) Lynsey M Whilding et al.   MOLECULAR THERAPY

Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients

(2013) Ilkka Liikanen et al.   MOLECULAR THERAPY

Oncolytic Virotherapy and Immunogenic Cancer Cell Death: Sharpening the Sword for Improved Cancer Treatment Strategies

(2013) Samuel T Workenhe et al.   MOLECULAR THERAPY

Immunogenic HSV-mediated Oncolysis Shapes the Antitumor Immune Response and Contributes to Therapeutic Efficacy

(2013) Samuel T Workenhe et al.   MOLECULAR THERAPY

T-cell Engager-armed Oncolytic Vaccinia Virus Significantly Enhances Antitumor Therapy

(2013) Feng Yu et al.   MOLECULAR THERAPY

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

(2013) Jeong Heo et al.   NATURE MEDICINE

Oncolytic virus therapy for cancer: the first wave of translational clinical trials

(2013) Manish R. Patel et al.   Translational Research

Combination of autophagy inducer rapamycin and oncolytic adenovirus improves antitumor effect in cancer cells

(2013) Pei-Hsin Cheng et al.   Virology Journal

Reovirus Activates a Caspase-Independent Cell Death Pathway

(2013) A. K. Berger et al.   mBio

Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity

(2013) Karla Tapia et al.   PLoS Pathogens

Combining Oncolytic HSV-1 with Immunogenic Cell Death-Inducing Drug Mitoxantrone Breaks Cancer Immune Tolerance and Improves Therapeutic Efficacy

(2013) S. T. Workenhe et al.   Cancer Immunology Research

Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication

(2012) Chunchun Meng et al.   ARCHIVES OF VIROLOGY

Avian reovirus triggers autophagy in primary chicken fibroblast cells and Vero cells to promote virus production

(2012) Songshu Meng et al.   ARCHIVES OF VIROLOGY

Activation of a glioma-specific immune response by oncolytic parvovirus Minute Virus of Mice infection

(2012) S P Grekova et al.   CANCER GENE THERAPY

Oncolytic Virus and Anti-4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer

(2012) L. B. John et al.   CANCER RESEARCH

Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

(2012) I. Diaconu et al.   CANCER RESEARCH

Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma

(2012) S. Miyamoto et al.   CANCER RESEARCH

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

The p17 Nonstructural Protein of Avian Reovirus Triggers Autophagy Enhancing Virus Replication via Activation of Phosphatase and Tensin Deleted on Chromosome 10 (PTEN) and AMP-activated Protein Kinase (AMPK), as well as dsRNA-dependent Protein Kinase (PKR)/eIF2α Signaling Pathways

(2012) Pei I Chi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNase L Triggers Autophagy in Response to Viral Infections

(2012) A. Chakrabarti et al.   JOURNAL OF VIROLOGY

Failure of Translation of Human Adenovirus mRNA in Murine Cancer Cells Can be Partially Overcome by L4-100K Expression In Vitro and In Vivo

(2012) Anna-Mary Young et al.   MOLECULAR THERAPY

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

ATP Release from Dying Autophagic Cells and Their Phagocytosis Are Crucial for Inflammasome Activation in Macrophages

(2012) Gizem Ayna et al.   PLoS One

Immune cells participate in the oncosuppressive activity of parvovirus H-1PV and are activated as a result of their abortive infection with this agent

(2011) Svitlana P. Grekova et al.   CANCER BIOLOGY & THERAPY

Tumor-Derived Autophagosome Vaccine: Mechanism of Cross-Presentation and Therapeutic Efficacy

(2011) Y. Li et al.   CLINICAL CANCER RESEARCH

Measles virus causes immunogenic cell death in human melanoma

(2011) O G Donnelly et al.   GENE THERAPY

Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity

(2011) Volker Schirrmacher   INTERNATIONAL JOURNAL OF ONCOLOGY

P2Y6 Receptor Signaling Pathway Mediates Inflammatory Responses Induced by Monosodium Urate Crystals

(2011) H. Uratsuji et al.   JOURNAL OF IMMUNOLOGY

Functional Macroautophagy Induction by Influenza A Virus without a Contribution to Major Histocompatibility Complex Class II-Restricted Presentation

(2011) J. D. Comber et al.   JOURNAL OF VIROLOGY

Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1

(2011) P Liu et al.   LEUKEMIA

Chemokine Expression From Oncolytic Vaccinia Virus Enhances Vaccine Therapies of Cancer

(2011) Jun Li et al.   MOLECULAR THERAPY

Oncolytic Sindbis Virus Targets Tumors Defective in the Interferon Response and Induces Significant Bystander Antitumor Immunity In Vivo

(2011) Pong-Yu Huang et al.   MOLECULAR THERAPY

Stepwise Release of Biologically Active HMGB1 during HSV-2 Infection

(2011) Chloé Borde et al.   PLoS One

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Adenoviruses induce autophagy to promote virus replication and oncolysis

(2011) Humberto Rodriguez-Rocha et al.   VIROLOGY

Pathogen recognition by the cell surface receptor CD46 induces autophagy

(2010) Grégory Meiffren et al.   Autophagy

Type III IFN Interleukin-28 Mediates the Antitumor Efficacy of Oncolytic Virus VSV in Immune-Competent Mouse Models of Cancer

(2010) Phonphimon Wongthida et al.   CANCER RESEARCH

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Virus Inhibition of RIP3-Dependent Necrosis

(2010) Jason W. Upton et al.   Cell Host & Microbe

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

OPTIM trial: a Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma

(2010) Howard L Kaufman et al.   Future Oncology

Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1

(2010) B Huang et al.   GENE THERAPY

Influenza A Infection Enhances Cross-Priming of CD8+ T Cells to Cell-Associated Antigens in a TLR7- and Type I IFN-Dependent Fashion

(2010) J. Wei et al.   JOURNAL OF IMMUNOLOGY

Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors

(2010) Ivan Zanoni et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Adaptive Antiviral Immunity Is a Determinant of the Therapeutic Success of Oncolytic Virotherapy

(2010) Paul T Sobol et al.   MOLECULAR THERAPY

The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status

(2010) M Kim et al.   ONCOGENE

An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells

(2010) J P Alameda et al.   ONCOGENE

Host Lymphodepletion Enhances the Therapeutic Activity of an Oncolytic Vaccinia Virus Expressing 4-1BB Ligand

(2009) H. S. Kim et al.   CANCER RESEARCH

Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells

(2009) M Uhl et al.   CELL DEATH AND DIFFERENTIATION

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

Immune-Mediated Antitumor Activity of Reovirus Is Required for Therapy and Is Independent of Direct Viral Oncolysis and Replication

(2009) R. J. Prestwich et al.   CLINICAL CANCER RESEARCH

Engineering oncolytic viruses to exploit tumor specific defects in innate immune signaling pathways

(2009) Shruthi Naik et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The HSV-2 mutant ΔPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins

(2009) A G Colunga et al.   GENE THERAPY

Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection

(2009) Luc English et al.   NATURE IMMUNOLOGY

Oncolytic virotherapy: Molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses

(2008) Z. Sheng Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Measles Virus Induces Oncolysis of Mesothelioma Cells and Allows Dendritic Cells to Cross-Prime Tumor-Specific CD8 Response

(2008) A. Gauvrit et al.   CANCER RESEARCH

Efficient Cross-presentation Depends on Autophagy in Tumor Cells

(2008) Y. Li et al.   CANCER RESEARCH

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die

(2008) J Thorburn et al.   CELL DEATH AND DIFFERENTIATION

Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity

(2008) R. J. Prestwich et al.   CLINICAL CANCER RESEARCH

Immunogenic cancer cell death: a key-lock paradigm

(2008) Antoine Tesniere et al.   CURRENT OPINION IN IMMUNOLOGY

Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma

(2008) F Errington et al.   GENE THERAPY

Inflammatory signals in dendritic cell activation and the induction of adaptive immunity

(2008) Olivier Joffre et al.   IMMUNOLOGICAL REVIEWS

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(2008) John Klune et al.   MOLECULAR MEDICINE

The Targeted Oncolytic Poxvirus JX-594 Demonstrates Antitumoral, Antivascular, and Anti-HBV Activities in Patients With Hepatocellular Carcinoma

(2008) Ta-Chiang Liu et al.   MOLECULAR THERAPY

Delta-24-RGD in Combination With RAD001 Induces Enhanced Anti-glioma Effect via Autophagic Cell Death

(2008) Marta M Alonso et al.   MOLECULAR THERAPY