Article
Biochemistry & Molecular Biology
Shijie Wen, Hiroshi Arakawa, Ikumi Tamai
Summary: This study revealed that MSU crystals can activate CD38, leading to a decrease in intracellular NAD(+) levels, thereby promoting inflammatory responses. Inhibition of CD38 can effectively suppress inflammatory responses triggered by MSU crystals, indicating that CD38 may be a potential therapeutic target for gout.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Raissa Timmerman, Ella A. Zuiderwijk-Sick, Jeffrey J. Bajramovic
Summary: TLR-induced signaling triggers inflammatory responses, and the P2Y6 receptor enhances pro-inflammatory cytokine levels, especially in microglia. Through transcriptome analysis, P2Y6 signaling amplifies pro-inflammatory responses in microglia by regulating the expression of target genes through modulation of transcription factors. Additionally, inhibition of P2Y6 signaling strongly induces heat shock protein expression. These findings shed new light on the specific pro-inflammatory role of P2Y6 signaling in neuroinflammation and may provide novel approaches to control brain inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chun-su Zhong, Bo Zeng, Jia-hao Qiu, Li-hui Xu, Mei-yan Zhong, Yuan-ting Huang, Rong Xu, Si-ying Liu, Qing-bing Zha, Bo Hu, Dong-yun Ou-Yang, Xian-hui He
Summary: Monosodium urate (MSU) crystals induce NLRP3-independent necrosis in gout, which can be inhibited by combined inhibitors targeting multiple signaling pathways.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Multidisciplinary Sciences
Zhipeng Meng, Fu-Long Li, Cao Fang, Benjamin Yeoman, Yunjiang Qiu, Ying Wang, Xiaomin Cai, Kimberly C. Lin, Di Yang, Min Luo, Vivian Fu, Xiaoxiao Ma, Yarui Diao, Filippo G. Giancotti, Bing Ren, Adam J. Engler, Kun-Liang Guan
Summary: This study reveals that class 3 Semaphorins (SEMA3s) activate the Hippo pathway to regulate tissue growth, angiogenesis, and tumorigenesis, highlighting the critical role of Hippo signaling in SEMA3 physiological function.
Article
Immunology
Anil K. Singh, Mahamudul Haque, Kayla O'Sullivan, Mukesh Chourasia, Madhu M. Ouseph, Salahuddin Ahmed
Summary: The study uncovers a novel post-translational mechanism of TAK1 activation by MSU crystals, suggesting the therapeutic potential of targeting TAK1 in regulating MSU-induced inflammation. MSU-induced proinflammatory cytokine production was completely inhibited by a TAK1 inhibitor in an in vivo mouse model, demonstrating the effectiveness of targeting this pathway in treating gout-related inflammation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Ertao Jia, Haiqiong Zhu, Hongling Geng, Li Zhong, Xia Qiu, Jingjing Xie, Yuya Xiao, Yubao Jiang, Min Xiao, Yanying Zhang, Jiaxin Wei, Dabin Tang, Jianyong Zhang
Summary: This study found that neutrophil-derived exosomes stimulated by monosodium urate (MSU) can inhibit the viability of osteoblasts and affect the expression levels of related genes, indicating that neutrophil-derived exosomes play a certain role in gouty bone erosion.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yessica Zamudio-Cuevas, Valentin Martinez-Lopez, Ivan Alejandro Lujan-Juarez, Nathalie Montano-Armendariz, Karina Martinez-Flores, Javier Fernandez-Torres, Miquel Gimeno, Roberto Sanchez-Sanchez
Summary: Gout is a chronic and degenerative disease caused by the crystalline deposit of monosodium urate, and poly-gallic acid has been found to be effective in reducing MSU-induced inflammation and oxidative stress.
Article
Cell Biology
Yessica Zamudio-Cuevas, Valentin Martinez-Lopez, Ivan Alejandro Lujan-Juarez, Nathalie Montano-Armendariz, Karina Martinez-Flores, Javier Fernandez-Torres, Miquel Gimeno, Roberto Sanchez-Sanchez
Summary: This study evaluated the effect of poly-gallic acid (PGAL) in an in vitro model of oxidation and synovial inflammation induced by monosodium urate (MSU) crystals. The results showed that PGAL reduced cell death and vesicle generation, decreased oxidative stress, and inhibited the inflammatory response. PGAL exhibited a cytoprotective effect against MSU-induced damage in synoviocytes.
Article
Genetics & Heredity
Tanja Linnerz, Yih Jian Sung, Leah Rolland, Jonathan W. Astin, Nicola Dalbeth, Christopher J. Hall
Summary: The article introduces the pathogenesis of gout and the study of a zebrafish uox null mutant, which has elevated urate levels and shows different response patterns, contributing to the research on the formation mechanism of tophus in gout.
Article
Immunology
Qi-Bin Yang, Ling-Qin Li, Quan-Bo Zhang, Yong-Long He, Qing-Sheng Mi, Jing-Guo Zhou
Summary: MiR-223 plays a crucial role in regulating inflammatory response in mouse models of gout, and its deficiency exacerbates inflammation. Lower levels of miR-223 in gout patients suggest that upregulation of miR-223 could be a potential therapeutic strategy for alleviating gouty inflammation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Jacob M. Dundee, Mar Puigdellivol, Richard Butler, Thomas O. J. Cockram, Guy C. Brown
Summary: Aging leads to loss of brain synapses and memory, possibly due to microglial phagocytosis of synapses. Activation of P2Y(6) receptor (P2Y(6)R) by UDP released from stressed neurons induces microglial phagocytosis. Inactivation of P2Y(6)R decreases microglial phagocytosis of synapses and prevents age-induced synaptic loss and memory impairment.
Article
Immunology
Dongni Huang, Yuxin Ran, Zheng Liu, Jie He, Nanlin Yin, Hongbo Qi
Summary: Preterm labor is a multifactorial syndrome that involves the abnormal expression of IL-27 and its receptors. This study demonstrated that the IL-27/IFN-γ/ERK axis mediates the inflammatory effect in preterm labor, and WSX-1 knockdown can delay birth. The findings suggest a potential therapeutic target in inhibiting the pro-inflammatory effect in preterm labor.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiang Ouyang, Na-Zhi Li, Min-Xia Guo, Man-Man Zhang, Jie Cheng, Li-Tao Yi, Ji-Xiao Zhu
Summary: The active flavonoids from Lagotis brachystachya effectively attenuated gouty arthritis induced by MSU crystal through inhibiting the TLR4/MyD88/NF-kappa B pathway and decreasing NLRP3 expression in vivo and in vitro, suggesting potential candidates for the treatment of gouty arthritis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peili Li, Yasutaka Kurata, Fikri Taufiq, Masanari Kuwabara, Haruaki Ninomiya, Katsumi Higaki, Motokazu Tsuneto, Yasuaki Shirayoshi, Miguel A. Lanaspa, Ichiro Hisatome
Summary: The role of the K+ channel Kv1.5 in monosodium urate crystal-induced activation of the NLRP3 inflammasome and electrical remodeling was investigated. The study found that Kv1.5 regulates MSU-induced activation of NLRP3 inflammasome in macrophages and that macrophages mediate MSU-related activation of NLRP3 inflammasome and electrical remodeling in HL-1 cells. Kv1.5 may have therapeutic value for diseases related to gout-induced activation of the NLRP3 inflammasome, including AF.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Bendong Yang, Meiling Xin, Shufei Liang, Yuhong Huang, Jingda Li, Chao Wang, Chao Liu, Xinhua Song, Jinyue Sun, Wenlong Sun
Summary: Naringenin reduces hyperuricemia and renal inflammation by promoting uric acid excretion and attenuating the release of inflammatory cytokines.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Masahiro Kamata, Yayoi Tada
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Dermatology
Kaoru Namiki, Masahiro Kamata, Teruo Shimizu, Chika Chijiwa, Hideaki Uchida, Shogo Okinaga, Midori Harafuji, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Hideaki Uchida, Masahiro Kamata, Mayumi Nagata, Saki Fukaya
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2020)
Article
Dermatology
Mari Kudo, Nobuko Ishiura, Miwa Tamura-Nakano, Teruo Shimizu, Masahiro Kamata, Eijiro Akasaka, Hajime Nakano, Yoshiaki Okuma, Yayoi Tada, Hitoshi Okochi, Takeshi Tamaki
JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Hideaki Uchida, Masahiro Kamata, Aika Kato, Itsumi Mizukawa, Ayu Watanabe, Ai Agematsu, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Letter
Dermatology
A. Agematsu, M. Kamata, H. Uchida, M. Nagata, S. Fukaya, K. Hayashi, A. Fukuyasu, T. Tanaka, T. Ishikawa, T. Ohnishi, Y. Tada, A. Kubo
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Letter
Dermatology
Shogo Okinaga, Masahiro Kamata, Teruo Shimizu, Makoto Ito, Hideaki Uchida, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
JOURNAL OF DERMATOLOGICAL SCIENCE
(2020)
Article
Dermatology
Aika Kato, Masahiro Kamata, Makoto Ito, Hideaki Uchida, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
JOURNAL OF DERMATOLOGY
(2020)
Letter
Pathology
Yuki Sano, Yoshinao Kikuchi, Shigeki Morita, Teruaki Oka, Koji Saito, Nanami Takeda, Kento Terashima, Hikaru Toyota, Hideaki Uchida, Shiori Watabe, Satoe Numakura, Shoki Miyoshi, Hiroyuki Nagase, Masahiro Kamata, Yayoi Tada, Hiroshi Uozaki
PATHOLOGY INTERNATIONAL
(2021)
Article
Dermatology
Kei Mukai, Masahiro Kamata, Mirei Miyazaki, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada, Takamitsu Tanaka
Summary: This case report highlights a patient with BRAF-mutated melanoma who developed adverse events including elevated D-dimer levels and pyrexia after receiving CombiDT and CombiEB treatments, which were prevented by concomitant edoxaban. This allowed the patient to continue receiving CombiEB therapy.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Atsuko Fukuyasu, Masahiro Kamata, Carren Sy Hau, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada, Naoko Kanda
Summary: The severity of herpes zoster is significantly correlated with the duration of postherpetic neuralgia, with serum IL-10 levels potentially serving as a practical predictor of neuralgia duration.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Iori Okura, Masahiro Kamata, Yoshihide Asano, Aya Mitsui, Teruo Shimizu, Shinichi Sato, Yayoi Tada
Summary: This study demonstrated that fingolimod effectively alleviated IMQ-induced psoriasiform dermatitis, suggesting its potential as a therapeutic agent for psoriasis.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Letter
Dermatology
Hideaki Uchida, Masahiro Kamata, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
JOURNAL OF DERMATOLOGY
(2021)
Article
Allergy
Hideaki Uchida, Masahiro Kamata, Shota Egawa, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
Summary: In this study, tacrolimus ointment was investigated for its effectiveness on facial lesions refractory to topical corticosteroid in AD patients receiving dupilumab, showing improvement in some patients after switching treatment methods.
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2022)
Letter
Allergy
Hideaki Uchida, Masahiro Kamata, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Kenjiro Mitsuhashi, Yayoi Tada
Summary: This case report presents a 44-year-old male patient with atopic dermatitis who developed malignant lymphoma (diffuse large B-cell lymphoma) during treatment with dupilumab.
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2021)