Article
Chemistry, Multidisciplinary
Jia Tan, Binbin Ding, Pan Zheng, Hao Chen, Ping'an Ma, Jun Lin
Summary: A new type of nanoadjuvant SiAl was synthesized in this study, which can significantly enhance immune response in therapeutic cancer vaccines and has potential for breast cancer treatment.
Article
Chemistry, Multidisciplinary
Yannan Yang, Zhengying Gu, Jie Tang, Min Zhang, Yang Yang, Hao Song, Chengzhong Yu
Summary: The study challenges the traditional view of MnO2 nanoparticles as merely assisting in cancer immunotherapy, revealing their intrinsic immunomodulatory property in inducing immunogenic cell death. This unique property is exploited for a new cancer starvation-immunotherapy approach, showing promising efficacy in suppressing local and distant tumors.
Article
Chemistry, Multidisciplinary
Xiang Xiong, Jingya Zhao, Rui Su, Chunping Liu, Xing Guo, Shaobing Zhou
Summary: The study introduces a novel strategy for enhanced tumor immunotherapy by combining different carriers to achieve targeted delivery to tumors and activation of immune response, resulting in improved efficacy in tumor therapy.
Review
Oncology
Razan Alzeibak, Tatiana A. Mishchenko, Natalia Y. Shilyagina, Irina V. Balalaeva, Maria V. Vedunova, Dmitri V. Krysko
Summary: The past decade has seen significant breakthroughs in cancer immunotherapy, with immunogenic cell death (ICD) emerging as a promising approach to eliminate tumor cells. Photodynamic therapy (PDT) can induce ICD, but its efficiency is reduced in hypoxic tumor environments. Future research may focus on strategies like oxygen-boosted PDT and nanotechnology to address this limitation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Seohyun Kim, Seong A. Kim, Gi-Hoon Nam, Yeonsun Hong, Gi Beom Kim, Yoonjeong Choi, Seokyoung Lee, Yuri Cho, Minsu Kwon, Cherlhyun Jeong, Sehoon Kim, In-San Kim
Summary: A targeted immunotherapeutic strategy involving local photodynamic therapy, a rho-kinase inhibitor, and PD-1/PD-L1 immune checkpoint blockade was proposed for uveal melanoma. This treatment approach demonstrated efficacy in promoting immunogenic clearance of primary tumors, preventing metastasis, and improving survival outcomes for patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Chemistry, Multidisciplinary
Zhilin Li, Xiaoqin Lai, Shiqin Fu, Long Ren, Hao Cai, Hu Zhang, Zhongwei Gu, Xuelei Ma, Kui Luo
Summary: This article reviews the use of nanostructure-based drug delivery systems (NDDSs) to enhance the effectiveness of tumor immunotherapy. By inducing immunogenic cell death (ICD) and releasing danger-associated molecular patterns (DAMPs) and tumor-associated antigens, in combination with chemotherapy, photodynamic therapy, photothermal therapy, and radiotherapy, the tumor immunosuppressive microenvironment can be improved, resulting in increased sensitivity to immunotherapy and reduced side effects.
Editorial Material
Oncology
Prathyusha Konda, Liubov M. Lifshits, John A. Roque, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Shashi Gujar
Summary: A new class of ruthenium-based photosensitizers have been discovered to induce potent cytotoxicity and immunogenic cell death in melanoma cells when activated by NIR light, potentially establishing protective antitumor immunity.
Article
Engineering, Biomedical
Jia Wan, Xianghong Zhang, Zhihong Li, Fuhao Mo, Dongsheng Tang, Haihua Xiao, Jingcheng Wang, Guanghua Rong, Tang Liu
Summary: ROS-responsive nanoparticles with mitochondrial targeting performance were designed to induce immunogenic cell death and trigger antitumor immune responses. By enhancing ROS damage and disrupting mitochondrial redox homeostasis, the nanoparticles promote cancer cell apoptosis and antitumor immune response, thus achieving cancer immunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xingheng Wang, Qian Li, Zhenyang Zhao, Lanlan Yu, Sichun Wang, Hong Pu, Mohsen Adeli, Li Qiu, Peng Gu, Ling Li, Chong Cheng
Summary: This study demonstrates the synthesis of a dual-functional artificial peroxidase with ferriporphyrin networks (FePorNW-DAP) that can serve as a tumor microenvironment (TME)-adaptive and ultrasound (US)-controllable reactive oxygen species (ROS)-generator for amplifying tumor immunotherapies. The FePorNW-DAP shows efficient dual-functional ROS production capabilities to combat tumor cells and amplify tumor immunotherapies. This research provides critical evidence for the induction of a strong antitumor immune response and immune memory by the proposed dual-functional artificial peroxidases, and offers essential guidance for creating high-performance and biocompatible strategies to regulate the immunosuppression TME and enhance the antitumor immune responses of breast cancer.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Sajal Sen, Krystle Karoscik, Esther Maier, Jonathan F. Arambula
Summary: The immune system plays a vital role in maintaining homeostasis and preventing the growth of malignant cells. Immune evasion by cancer cells is a major challenge, but efforts have been made to activate the immune response through immunogenic cell death (ICD) and metal-based compounds. The development of novel ICD inducers and understanding the biological pathways associated with ICD are important for enhancing anticancer immune responses. This review provides a concise summary of these topics and discusses the early clinical evidence and future directions of ICD.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Oncology
Carmen Aguilar-Gurrieri, Ana Barajas, Carla Rovirosa, Raquel Ortiz, Victor Urrea, Nuria de la Iglesia, Bonaventura Clotet, Julia Blanco, Jorge Carrillo
Summary: Neoantigens are tumor-specific antigens that can elicit a specific immune response. They have potential for the development of personalized cancer vaccines. The presentation of neoantigens to T cells is influenced by vaccine delivery strategies, including the use of specific linkers. The efficiency of neoantigen processing and presentation by MHC-I molecules can be improved with alanine-based linkers.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Materials Science, Biomaterials
Ya Wen, Yiqiong Liu, Fangfang Guo, Yi Han, Qiansai Qiu, Yan Li, Haiqing Dong, Tianbin Ren, Yongyong Li
Summary: The study proposes an in vitro method for inducing ICD to overcome the impact of the immunosuppressive microenvironment on anticancer immunity. By generating a hot whole tumor cell vaccine and subcutaneously vaccinating it in normal tissue, the study effectively promotes T-cell responses and protects mice from tumor initiation.
BIOMATERIALS SCIENCE
(2021)
Review
Genetics & Heredity
Evangelos Koustas, Eleni-Myrto Trifylli, Panagiotis Sarantis, Nikolaos Papadopoulos, Konstantinos Papanikolopoulos, Georgios Aloizos, Christos Damaskos, Nikolaos Garmpis, Anna Garmpi, Dimitris Matthaios, Michalis. V. V. Karamouzis
Summary: Autophagy is a crucial process for cell degradation and recycling, which affects cellular functions and is associated with tumorigenesis, tumor-stroma interactions, and resistance to cancer therapy. It influences the tumor microenvironment and plays a key role in immune cell functions, neo-antigen presentation, and cross-presentation. Autophagy is currently an important target in immunotherapy.
Article
Chemistry, Multidisciplinary
Jie Zhang, Biao Fan, Guoliang Cao, Wenping Huang, Fuhao Jia, Guangjun Nie, Hai Wang
Summary: This study developed a personalized DC-mimicking nanovaccine for stimulating TAAs-specific T cell populations. By inducing BMDCs maturation and delivering TAAs through nanostructures, the nanoDCs efficiently generated potent antigen-specific T cell responses, leading to inhibition of tumor growth and metastases formation.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Fengqi Zhou, Jing Gao, Yang Tang, Zhifeng Zou, Shi Jiao, Zhaocai Zhou, Huixiong Xu, Zhi Ping Xu, Haijun Yu, Zhiai Xu
Summary: This research addresses the issue of immune evasion in T-cell-based cancer immunotherapy by developing a multifunctional prodrug nanovesicle. By enhancing tumor antigen presentation and the infiltration of T lymphocytes, the prodrug nanovesicles demonstrate efficacy in overcoming immune resistance and potentiate tumor immunotherapy.
ADVANCED MATERIALS
(2021)
Article
Cell Biology
Dae-Hee Lee, Daeho Kim, Sung Tae Kim, Soyeon Jeong, Jung Lim Kim, Sang Mi Shim, Ah Jung Heo, Xinxin Song, Zong Sheng Guo, David L. Bartlett, Sang Cheul Oh, Junho Lee, Yoshiro Saito, Bo Yeon Kim, Yong Tae Kwon, Yong J. Lee
Article
Biotechnology & Applied Microbiology
Stacy J. Kowalsky, Zuqiang Liu, Mathilde Feist, Sara E. Berkey, Congrong Ma, Roshni Ravindranathan, Enyong Dai, Edward J. Roy, Zong Sheng Guo, David L. Bartlett
Editorial Material
Oncology
Zong Sheng Guo
Review
Oncology
Zong Sheng Guo, Binfeng Lu, Zongbi Guo, Esther Giehl, Mathilde Feist, Enyong Dai, Weilin Liu, Walter J. Storkus, Yukai He, Zuqiang Liu, David L. Bartlett
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Oncology
Bingtao Tang, Zong Sheng Guo, David L. Bartlett, David Z. Yan, Claire P. Schane, Diana L. Thomas, Jia Liu, Grant McFadden, Joanna L. Shisler, Edward J. Roy
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Yan Ge, Haiyan Wang, Jinghua Ren, Weilin Liu, Lingjuan Chen, Hongqi Chen, Junjie Ye, Enyong Dai, Congrong Ma, Songguang Ju, Zong Sheng Guo, Zuqiang Liu, David L. Bartlett
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Fan Sun, Zong Sheng Guo, Alyssa D. Gregory, Steven D. Shapiro, Gutian Xiao, Zhaoxia Qu
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Biotechnology & Applied Microbiology
Mathilde Feist, Zhi Zhu, Enyong Dai, Congrong Ma, Zuqiang Liu, Esther Giehl, Roshni Ravindranathan, Stacy J. Kowalsky, Natasa Obermajer, Udai S. Kammula, Andrew J. H. Lee, Michael T. Lotze, Zong Sheng Guo, David L. Bartlett
Summary: The use of oncolytic virus (OV) can stimulate tumor-specific TIL, which show significant therapeutic effects in experiments after expansion, providing a potential option for adoptive cell therapy (ACT) for solid tumors.
CANCER GENE THERAPY
(2021)
Article
Oncology
Weilin Liu, Enyong Dai, Zuqiang Liu, Congrong Ma, Zong Sheng Guo, David L. Bartlett
MOLECULAR THERAPY-ONCOLYTICS
(2020)
Review
Biochemistry & Molecular Biology
Zong Sheng Guo, Michael T. Lotze, Zhi Zhu, Walter J. Storkus, Xiao-Tong Song
Editorial Material
Oncology
Zong-Sheng Guo
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Editorial Material
Biochemistry & Molecular Biology
Zong-Sheng Guo
Review
Biochemistry & Molecular Biology
Enyong Dai, Zhi Zhu, Shudipto Wahed, Zhaoxia Qu, Walter J. Storkus, Zong Sheng Guo
Summary: Epigenetic mechanisms play important roles in cancer initiation and immune cell function, with the potential to impact tumor microenvironment and therapeutic efficacy by modulating immune cell populations and promoting transcriptional and metabolic reprogramming. By regulating immune-associated genes and immune checkpoint molecules, epigenetic modulating agents can enhance tumor immunogenicity and facilitate anti-tumor immune responses.
Article
Biochemistry & Molecular Biology
Weilin Liu, Hongqi Chen, Zhi Zhu, Zuqiang Liu, Congrong Ma, Yong J. Lee, David L. Bartlett, Zong-Sheng Guo
Summary: The study found that the combination of the ferroptosis activator Erastin with the oncolytic vaccinia virus could effectively inhibit tumor growth, prolong host survival, and enhance antitumoral immunity in hepatocellular carcinoma and colon cancer models.
Meeting Abstract
Oncology
Bingtao Tang, Zong Sheng Guo, David L. Bartlett, David Yan, Claire P. Schane, Jia Liu, Grant McFadden, Joanna L. Shisler, Edward J. Roy