Article
Microbiology
Shiwen Peng, Louise Ferrall, Stephanie Gaillard, Chenguang Wang, Wei-Yu Chi, Chuan-Hsiang Huang, Richard B. S. Roden, T-C Wu, Yung-Nien Chang, Chien-Fu Hung
Summary: Immunotherapy for cervical cancer targeting high-risk human papillomavirus types 16 and 18 shows promising results in preclinical studies, with pBI-11 DNA vaccine inducing strong immune responses and therapeutic effects in mouse models. Combination with TA-HPV boost and PD-1 antibody blockade improves tumor control and survival. Clinical translation of this strategy may provide a new approach for HPV16/18-associated tumors.
Article
Virology
Leon C. W. Lin, Sarah N. Croft, Nathan P. Croft, Yik Chun Wong, Stewart A. Smith, Swee-Seong Tang, Anthony W. Purcell, David C. Tscharke
Summary: The study investigated the CD8(+) T cell priming pathways for Vaccinia virus (VACV) by engineering the virus to express inhibitors of antigen presentation. While the inhibitors had diverse impacts on CD8(+) T cell responses, unexpectedly, the direct priming of CD8(+) T cells by poxviruses was robust enough to withstand potent viral inhibitors of antigen presentation. This demonstrates the flexibility and robustness of immune processes in activating immune responses required to fight infection.
JOURNAL OF VIROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jaehyung Park, Hannah Frizzell, Hangyu Zhang, Shijie Cao, Sean M. Hughes, Florian Hladik, David M. Koelle, Kim A. Woodrow
Summary: The study found that chitosan facilitates the transmigration of DCs across the vaginal epithelium in the mouse female reproductive tract. Additionally, ex vivo programming of DCs was shown to enhance the migration of intravaginally administered DCs to draining lymph nodes and stimulate the proliferation of T cells, showing potential to improve the efficacy of DC-based vaccines in the female genital mucosa.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Hematology
Suzy A. Eldershaw, Hayden Pearce, Charlotte F. Inman, Karen P. Piper, Ben Abbotts, Christine Stephens, Samantha Nicol, Wayne Croft, Richard Powell, Jusnara Begum, Graham Taylor, Jane Nunnick, Donna Walsh, Mirjana Sirovica, Shamyla Saddique, Sandeep Nagra, Paul Ferguson, Paul Moss, Ram Malladi
Summary: Immune responses involving HA-1 prime-boost vaccination can induce strong and specific T cell responses in donors or patients, leading to enhanced graft-versus-leukaemia effects. This approach shows promising potential and efficacy in experimental settings.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Rebecca L. Riding, Jillian M. Richmond, Keitaro Fukuda, John E. Harris
Summary: The study found that type I IFN plays an important role in the progression of vitiligo, and blocking type I IFNs may help improve the efficacy of melanoma immunotherapy, as shown by two different mouse models.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Immunology
Ting Huang, Kelei Zhao, Xuhao Song, Tao Song, Xinrong Wang, Xiuyue Zhang, Bisong Yue, Yiwen Chu
Summary: This study developed a heterologous prime-boost vaccination scheme utilizing a DNA vaccine and a subunit vaccine to enhance immune responses against T. pyogenes in mice. The results showed that this vaccination strategy reduced bacterial burdens and boosted humoral and cellular immune responses, effectively protecting the mice from T. pyogenes infection.
Article
Oncology
Jian L. Campian, Subhajit Ghosh, Vaishali Kapoor, Ran Yan, Sukrutha Thotala, Arijita Jash, Tong Hu, Anita Mahadevan, Kasem Rifai, Logan Page, Byung Ha Lee, Sara Ferrando-Martinez, Alexandra A. Wolfarth, Se Hwan Yang, Dennis Hallahan, Milan G. Chheda, Dinesh Thotala
Summary: In this study, NT-17 was found to prevent systemic lymphopenia in GBM patients receiving radiotherapy and temozolomide, while improving survival. Furthermore, NT-17 increased cytotoxic CD8 T lymphocytes in lymphoid organs and tumor.
CLINICAL CANCER RESEARCH
(2022)
Article
Virology
Puja Bagri, Ramtin Ghasemi, Joshua J. C. McGrath, Danya Thayaparan, Emma Yu, Andrew G. Brooks, Martin R. Staempfli, Charu Kaushic
Summary: This study reveals a new role for E2 in enhancing CD4(+) memory T cells postintranasal immunization with HSV-2. Under the influence of E2 treatment, there is an enhanced establishment of antiviral memory T cell responses in the upper respiratory tract and female reproductive tract, with greater T(h)17 memory cells preceding enhanced T(h)1 memory responses. The findings suggest potential strategies for generating optimal immunity during vaccination.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Hewei Zhang, Jingqiang Ren, Jiachen Lid, Chongkai Zhai, Fuchao Mao, Shaozhe Yang, Qingwei Zhang, Zhongyu Liu, Xiuhong Fu
Summary: This study investigated the immunogenicity and protective efficacy of different vaccination regimens for pigs against PRRSV infection. The findings suggest that a heterologous prime-boost vaccine regimen can improve immune responses and provide resistance to PRRSV infection in pigs.
MICROBIAL PATHOGENESIS
(2023)
Article
Infectious Diseases
Min-Ju Kim, Ki-Back Chu, Su-Hwa Lee, Hae-Ji Kang, Keon-Woong Yoon, Md Atique Ahmed, Fu-Shi Quan
Summary: Recombinant vaccinia viruses (rVV) expressing either AMA1 or MIC were compared for their efficacies as vaccine candidates in mice. Both vaccines elicited parasite-specific antibody responses and high levels of T cell and germinal center B cell responses. However, MIC vaccine induced higher levels of cellular immune response and significantly reduced pro-inflammatory cytokine productions compared to AMA1 vaccine. Prolonged survival was observed in mice immunized with MIC vaccine. These findings suggest that MIC could be a more promising vaccine candidate antigen.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Dermatology
LiangHong Chen, Yan Wu, Yan Sun, Shuai Qiao, BiHuan Xiao, JingYu Wang, Qian An, XingHua Gao
Summary: A combined therapy of local rhIFN alpha 1b injection plus acupuncture was evaluated for the treatment of verruca vulgaris. The study found that the cure rates in the combined therapy group were 81.85%, while in the control groups they were 85.93% and 100% respectively. The local injection of interferon showed efficacy and safety in treating verruca vulgaris.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Oncology
Ruey-Shyang Soong, Liwen Song, Janson Trieu, Jayne Knoff, Liangmei He, Ya-Chea Tsai, Warner Huh, Yung-Nien Chang, Wen-Fang Cheng, Richard B. S. Roden, T. -C. Wu, Cornelia L. Trimble, Chien-Fu Hung
CLINICAL CANCER RESEARCH
(2014)
Article
Multidisciplinary Sciences
Ruey-Shyang Soong, Liwen Song, Janson Trieu, Sung Yong Lee, Liangmei He, Ya-Chea Tsai, T. -C. Wu, Chien-Fu Hung
Article
Immunology
Liwen Song, Ming-Chieh Yang, Jayne Knoff, Zu-Yue Sun, T. -C Wu, Chien-Fu Hung
Article
Biochemistry & Molecular Biology
Shiwen Peng, Liwen Song, Jayne Knoff, Joshua W. Wang, Yung-Nien Chang, Drew Hannaman, T-C Wu, Ronald D. Alvarez, Richard B. S. Roden, Chien-Fu Hung
CELL AND BIOSCIENCE
(2014)