标题
The promise and perils of HDAC inhibitors in neurodegeneration
作者
关键词
-
出版物
Annals of Clinical and Translational Neurology
Volume 2, Issue 1, Pages 79-101
出版商
Wiley
发表日期
2014-12-05
DOI
10.1002/acn3.147
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Epigenetic therapy for Friedreich ataxia
- (2014) Elisabetta Soragni et al. ANNALS OF NEUROLOGY
- Epigenetic promoter silencing in Friedreich ataxia is dependent on repeat length
- (2014) Yogesh K. Chutake et al. ANNALS OF NEUROLOGY
- Polyglutamine-expanded ataxin-3 impairs long-term depression in Purkinje neurons of SCA3 transgenic mouse by inhibiting HAT and impairing histone acetylation
- (2014) An-Hsun Chou et al. BRAIN RESEARCH
- The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1
- (2014) Anand Venkatraman et al. HUMAN MOLECULAR GENETICS
- Loss of SIRT4 decreases GLT-1-dependent glutamate uptake and increases sensitivity to kainic acid
- (2014) Jennifer Shih et al. JOURNAL OF NEUROCHEMISTRY
- HDAC1 and HDAC2 Control the Specification of Neural Crest Cells into Peripheral Glia
- (2014) C. Jacob et al. JOURNAL OF NEUROSCIENCE
- Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study
- (2014) Vincenzo Libri et al. LANCET
- Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia
- (2014) Morgane Perdomini et al. NATURE MEDICINE
- SIRT1 in Neurodevelopment and Brain Senescence
- (2014) A. Zara Herskovits et al. NEURON
- SIRT6 Is Required for Normal Retinal Function
- (2014) Dafne M. Silberman et al. PLoS One
- HDAC3 controls gap 2/mitosis progression in adult neural stem/progenitor cells by regulating CDK1 levels
- (2014) Yindi Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition
- (2014) Maj-Linda Selenica et al. Alzheimers Research & Therapy
- Spinal muscular atrophy: Development and implementation of potential treatments
- (2013) W. David Arnold et al. ANNALS OF NEUROLOGY
- Lysine deacetylases and mitochondrial dynamics in neurodegeneration
- (2013) Pedro Guedes-Dias et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Diagnostic laboratory testing for Charcot Marie Tooth disease (CMT): the spectrum of gene defects in Norwegian patients with CMT and its implications for future genetic test strategies
- (2013) Rune Østern et al. BMC Medical Genetics
- Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration
- (2013) Yongcheol Cho et al. CELL
- SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
- (2013) Hung-Chun Chang et al. CELL
- Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
- (2013) Tsutomu Sasaki et al. DIABETOLOGIA
- Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
- (2013) Jafar Mohseni et al. GENETICS AND MOLECULAR BIOLOGY
- Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
- (2013) Casey Cook et al. HUMAN MOLECULAR GENETICS
- MeCP2: a novel Huntingtin interactor
- (2013) K. N. McFarland et al. HUMAN MOLECULAR GENETICS
- Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS
- (2013) Ines Taes et al. HUMAN MOLECULAR GENETICS
- Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3
- (2013) P. K. Chan et al. HUMAN MOLECULAR GENETICS
- Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues
- (2013) Min Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HDAC3 Is a Negative Regulator of Cocaine-Context-Associated Memory Formation
- (2013) G. A. Rogge et al. JOURNAL OF NEUROSCIENCE
- Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action
- (2013) D. Ferguson et al. JOURNAL OF NEUROSCIENCE
- Loss of Histone Deacetylase 2 Improves Working Memory and Accelerates Extinction Learning
- (2013) M. J. Morris et al. JOURNAL OF NEUROSCIENCE
- SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
- (2013) Sumiti Saharan et al. JOURNAL OF NEUROSCIENCE RESEARCH
- SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase
- (2013) Gaëlle Laurent et al. MOLECULAR CELL
- Sirt1 Promotes Axonogenesis by Deacetylation of Akt and Inactivation of GSK3
- (2013) Xiao-hong Li et al. MOLECULAR NEUROBIOLOGY
- SMA valiant trial: A prospective, double-blind, placebo-controlled trial of valproic acid in ambulatory adults with spinal muscular atrophy
- (2013) John T. Kissel et al. MUSCLE & NERVE
- Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
- (2013) Victoria A. Rafalski et al. NATURE CELL BIOLOGY
- The changing scene of amyotrophic lateral sclerosis
- (2013) Wim Robberecht et al. NATURE REVIEWS NEUROSCIENCE
- Sorting out functions of sirtuins in cancer
- (2013) M Roth et al. ONCOGENE
- Niemann–Pick's and Gaucher's diseases
- (2013) Gerald Stern PARKINSONISM & RELATED DISORDERS
- Cytoplasmic Location of α1A Voltage-Gated Calcium Channel C-Terminal Fragment (Cav2.1-CTF) Aggregate Is Sufficient to Cause Cell Death
- (2013) Makoto Takahashi et al. PLoS One
- Sodium Valproate Alleviates Neurodegeneration in SCA3/MJD via Suppressing Apoptosis and Rescuing the Hypoacetylation Levels of Histone H3 and H4
- (2013) Jiping Yi et al. PLoS One
- HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila
- (2013) Y. Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
- (2013) Marina M. Bellet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation
- (2013) Natsumi Ageta-Ishihara et al. Nature Communications
- Sequestration of DROSHA and DGCR8 by Expanded CGG RNA Repeats Alters MicroRNA Processing in Fragile X-Associated Tremor/Ataxia Syndrome
- (2013) Chantal Sellier et al. Cell Reports
- HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration
- (2013) Michal Mielcarek et al. PLOS BIOLOGY
- HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory
- (2012) Richard Sando et al. CELL
- Understanding the genetic and molecular pathogenesis of Friedreich's ataxia through animal and cellular models
- (2012) A. Martelli et al. Disease Models & Mechanisms
- Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease
- (2012) Nambirajan Govindarajan et al. EMBO Molecular Medicine
- Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin–proteasomal and autophagy systems
- (2012) Haiqun Jia et al. HUMAN MOLECULAR GENETICS
- Charcot-Marie-Tooth disease: Emerging mechanisms and therapies
- (2012) Constantin d’Ydewalle et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death
- (2012) Farah H. Bardai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective Inhibitors
- (2012) Maria Fridén-Saxin et al. JOURNAL OF MEDICINAL CHEMISTRY
- An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation
- (2012) M.-S. Kim et al. JOURNAL OF NEUROSCIENCE
- HDAC1 Regulates Fear Extinction in Mice
- (2012) S. Bahari-Javan et al. JOURNAL OF NEUROSCIENCE
- HDAC6 Regulates Glucocorticoid Receptor Signaling in Serotonin Pathways with Critical Impact on Stress Resilience
- (2012) J. Espallergues et al. JOURNAL OF NEUROSCIENCE
- The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis
- (2012) John E. Dominy et al. MOLECULAR CELL
- HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle
- (2012) Matthew A. Deardorff et al. NATURE
- LANP mediates neuritic pathology in Spinocerebellar ataxia type 1
- (2012) Marija Cvetanovic et al. NEUROBIOLOGY OF DISEASE
- Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease
- (2012) Haiqun Jia et al. NEUROBIOLOGY OF DISEASE
- Loss of Deacetylation Activity of Hdac6 Affects Emotional Behavior in Mice
- (2012) Masahide Fukada et al. PLoS One
- Genetic Knock-Down of Hdac3 Does Not Modify Disease-Related Phenotypes in a Mouse Model of Huntington's Disease
- (2012) Lara Moumné et al. PLoS One
- SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo
- (2012) Anna Bobrowska et al. PLoS One
- Role of the CCAAT-Binding Protein NFY in SCA17 Pathogenesis
- (2012) Li-Ching Lee et al. PLoS One
- HDAC6 Inhibitor Blocks Amyloid Beta-Induced Impairment of Mitochondrial Transport in Hippocampal Neurons
- (2012) Chaeyoung Kim et al. PLoS One
- SIRT1 Regulates Dendritic Development in Hippocampal Neurons
- (2012) Juan F. Codocedo et al. PLoS One
- Drosophila Pur-α binds to trinucleotide-repeat containing cellular RNAs and translocates to the early oocyte
- (2012) Verena Aumiller et al. RNA Biology
- The neurobiology of sirtuins and their role in neurodegeneration
- (2012) Gizem Donmez TRENDS IN PHARMACOLOGICAL SCIENCES
- The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models
- (2012) Vanita Chopra et al. Cell Reports
- ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice
- (2012) Ewa Damrath et al. PLoS Genetics
- A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase
- (2011) David M. Taylor et al. ACS Chemical Biology
- Evaluation of muscle strength and motor abilities in children with type II and III spinal muscle atrophy treated with valproic acid
- (2011) Illora A Darbar et al. BMC Neurology
- Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis
- (2011) Young-Eun Yoo et al. EXPERIMENTAL NEUROLOGY
- FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3
- (2011) Julieta Araujo et al. HUMAN MOLECULAR GENETICS
- HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation
- (2011) S. C. McQuown et al. JOURNAL OF NEUROSCIENCE
- Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3
- (2011) F. H. Bardai et al. JOURNAL OF NEUROSCIENCE
- Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
- (2011) Han-Xiang Deng et al. NATURE
- Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1
- (2011) Marija Cvetanovic et al. NATURE MEDICINE
- HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease
- (2011) Constantin d'Ydewalle et al. NATURE MEDICINE
- Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model
- (2011) Chiranjeevi Sandi et al. NEUROBIOLOGY OF DISEASE
- Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease
- (2011) Chi-Tso Chiu et al. NEUROPSYCHOPHARMACOLOGY
- Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia
- (2011) E. Kim et al. NUCLEIC ACIDS RESEARCH
- Hdac6 Knock-Out Increases Tubulin Acetylation but Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease
- (2011) Anna Bobrowska et al. PLoS One
- Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function
- (2011) Dongmei Wu et al. PLoS One
- SMA CARNI-VAL TRIAL PART II: A Prospective, Single-Armed Trial of L-Carnitine and Valproic Acid in Ambulatory Children with Spinal Muscular Atrophy
- (2011) John T. Kissel et al. PLoS One
- SAHA Decreases HDAC 2 and 4 Levels In Vivo and Improves Molecular Phenotypes in the R6/2 Mouse Model of Huntington's Disease
- (2011) Michal Mielcarek et al. PLoS One
- Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts
- (2011) N. H. Pipalia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling
- (2011) B. Beirowski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protective effects and mechanisms of sirtuins in the nervous system
- (2011) Feng Zhang et al. PROGRESS IN NEUROBIOLOGY
- Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry
- (2010) Erika N. Ebbel et al. ANALYTICAL BIOCHEMISTRY
- Maladie de Niemann-Pick type C : aspects historiques et actuels, diagnostic biochimique et génétique
- (2010) Marie T. Vanier ARCHIVES DE PEDIATRIE
- SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity
- (2010) Giorgio Ramadori et al. Cell Metabolism
- Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients
- (2010) Chantal Sellier et al. EMBO JOURNAL
- HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy
- (2010) Joo-Yong Lee et al. EMBO JOURNAL
- Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation
- (2010) Tanel Punga et al. EMBO Molecular Medicine
- Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells
- (2010) Toshiya Sugino et al. FEBS LETTERS
- SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy
- (2010) Markus Riessland et al. HUMAN MOLECULAR GENETICS
- The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome
- (2010) D. Kumari et al. HUMAN MOLECULAR GENETICS
- Histone Deacetylase 9 (HDAC9) Regulates the Functions of the ATDC (TRIM29) Protein
- (2010) Zhigang Yuan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Repeat Expansion Affects Both Transcription Initiation and Elongation in Friedreich Ataxia Cells
- (2010) Daman Kumari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310
- (2010) K. M. Rothgiesser et al. JOURNAL OF CELL SCIENCE
- SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
- (2010) S. Michan et al. JOURNAL OF NEUROSCIENCE
- SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus
- (2010) A. Satoh et al. JOURNAL OF NEUROSCIENCE
- Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A
- (2010) Kyle V. Butler et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation
- (2010) Jurre Hageman et al. MOLECULAR CELL
- A novel pathway regulates memory and plasticity via SIRT1 and miR-134
- (2010) Jun Gao et al. NATURE
- Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
- (2010) Andrew C. Elden et al. NATURE
- Mutations of optineurin in amyotrophic lateral sclerosis
- (2010) Hirofumi Maruyama et al. NATURE
- HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3
- (2010) An-Hsun Chou et al. NEUROBIOLOGY OF DISEASE
- Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease
- (2010) Tyisha Hathorn et al. NEUROBIOLOGY OF DISEASE
- Two New Pimelic Diphenylamide HDAC Inhibitors Induce Sustained Frataxin Upregulation in Cells from Friedreich's Ataxia Patients and in a Mouse Model
- (2010) Myriam Rai et al. PLoS One
- HDAC6 Regulates Mitochondrial Transport in Hippocampal Neurons
- (2010) Sigeng Chen et al. PLoS One
- Impaired Function of HDAC6 Slows Down Axonal Growth and Interferes with Axon Initial Segment Development
- (2010) Mónica Tapia et al. PLoS One
- SMA CARNI-VAL Trial Part I: Double-Blind, Randomized, Placebo-Controlled Trial of L-Carnitine and Valproic Acid in Spinal Muscular Atrophy
- (2010) Kathryn J. Swoboda et al. PLoS One
- Deficits in axonal transport precede ALS symptoms in vivo
- (2010) L. G. Bilsland et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
- (2010) Ruth Luthi-Carter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
- (2010) B. Schwer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
- (2010) Abderrahmane Kaidi et al. SCIENCE
- Histone Deacetylases Suppress CGG Repeat–Induced Neurodegeneration Via Transcriptional Silencing in Models of Fragile X Tremor Ataxia Syndrome
- (2010) Peter K. Todd et al. PLoS Genetics
- A Distinct DNA-Methylation Boundary in the 5′- Upstream Sequence of the FMR1 Promoter Binds Nuclear Proteins and Is Lost in Fragile X Syndrome
- (2009) Anja Naumann et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis
- (2009) Sanne Piepers et al. ANNALS OF NEUROLOGY
- Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection
- (2009) Kenichi Kakefuda et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
- (2009) Takashi Nakagawa et al. CELL
- Chemical Probes Identify a Role for Histone Deacetylase 3 in Friedreich's Ataxia Gene Silencing
- (2009) Chunping Xu et al. CHEMISTRY & BIOLOGY
- A phosphorylation-acetylation switch regulates STAT1 signaling
- (2009) O. H. Kramer et al. GENES & DEVELOPMENT
- Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
- (2009) D. E. Cohen et al. GENES & DEVELOPMENT
- Neuronal Differentiation Is Regulated by Leucine-rich Acidic Nuclear Protein (LANP), a Member of the Inhibitor of Histone Acetyltransferase Complex
- (2009) Rupinder K. Kular et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Histone Deacetylase 10 Relieves Repression on the Melanogenic Program by Maintaining the Deacetylation Status of Repressors
- (2009) I-Lu Lai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NAD+-dependent Deacetylase SIRT3 Regulates Mitochondrial Protein Synthesis by Deacetylation of the Ribosomal Protein MRPL10
- (2009) Yongjie Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HDAC6 Modulates Hsp90 Chaperone Activity and Regulates Activation of Aryl Hydrocarbon Receptor Signaling
- (2009) Vikram D. Kekatpure et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Function and biogenesis of iron–sulphur proteins
- (2009) Roland Lill NATURE
- HDAC2 negatively regulates memory formation and synaptic plasticity
- (2009) Ji-Song Guan et al. NATURE
- HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction
- (2009) Feng Ye et al. NATURE NEUROSCIENCE
- A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human α-synuclein A30P+A53T transgenic mice
- (2009) Kazuhiko Ono et al. PARKINSONISM & RELATED DISORDERS
- Modest reactivation of the mutant FMR1 gene by valproic acid is accompanied by histone modifications but not DNA demethylation
- (2009) Elisabetta Tabolacci et al. Pharmacogenetics and Genomics
- Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease
- (2009) Dénes Zádori et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Genetic Knock-Down of HDAC7 Does Not Ameliorate Disease Pathogenesis in the R6/2 Mouse Model of Huntington's Disease
- (2009) Caroline L. Benn et al. PLoS One
- Phase II Open Label Study of Valproic Acid in Spinal Muscular Atrophy
- (2009) Kathryn J. Swoboda et al. PLoS One
- Epigenetic Silencing in Friedreich Ataxia Is Associated with Depletion of CTCF (CCCTC-Binding Factor) and Antisense Transcription
- (2009) Irene De Biase et al. PLoS One
- Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development
- (2009) R. L. Montgomery et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas
- (2009) B. Chen et al. SCIENCE
- Instability and chromatin structure of expanded trinucleotide repeats
- (2009) Vincent Dion et al. TRENDS IN GENETICS
- Phase 2 study of sodium phenylbutyrate in ALS
- (2008) Merit E. Cudkowicz et al. Amyotrophic Lateral Sclerosis
- Charcot-Marie-Tooth Disease: A Clinico-genetic Confrontation
- (2008) N. Barisic et al. ANNALS OF HUMAN GENETICS
- SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
- (2008) Ying Li et al. Cell Metabolism
- Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice
- (2008) Olesya Vakhrusheva et al. CIRCULATION RESEARCH
- Tubulin modifications and their cellular functions
- (2008) Jennetta W Hammond et al. CURRENT OPINION IN CELL BIOLOGY
- HDAC4 inhibits cell-cycle progression and protects neurons from cell death
- (2008) Nazanin Majdzadeh et al. Developmental Neurobiology
- Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates
- (2008) Lei Wang et al. EMBO REPORTS
- Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease
- (2008) Judit Pallos et al. HUMAN MOLECULAR GENETICS
- Autoacetylation Regulates P/CAF Nuclear Localization
- (2008) Noemí Blanco-García et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Niemann-Pick Type C1 I1061T Mutant Encodes a Functional Protein That Is Selected for Endoplasmic Reticulum-associated Degradation Due to Protein Misfolding
- (2008) Mark E. Gelsthorpe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HDAC6 Is Required for Epidermal Growth Factor-induced β-Catenin Nuclear Localization
- (2008) Yu Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HDAC4 and PCAF Bind to Cardiac Sarcomeres and Play a Role in Regulating Myofilament Contractile Activity
- (2008) Mahesh P. Gupta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5
- (2008) Christine Schlicker et al. JOURNAL OF MOLECULAR BIOLOGY
- Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability
- (2008) G. Ramadori et al. JOURNAL OF NEUROSCIENCE
- SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70
- (2008) N. R. Sundaresan et al. MOLECULAR AND CELLULAR BIOLOGY
- Sirt1 contributes critically to the redox-dependent fate of neural progenitors
- (2008) Timour Prozorovski et al. NATURE CELL BIOLOGY
- The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance
- (2008) Alejandro Villagra et al. NATURE IMMUNOLOGY
- Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
- (2008) Aleksey G. Kazantsev et al. NATURE REVIEWS DRUG DISCOVERY
- The many roles of histone deacetylases in development and physiology: implications for disease and therapy
- (2008) Michael Haberland et al. NATURE REVIEWS GENETICS
- HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model
- (2008) Myriam Rai et al. PLoS One
- Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity
- (2008) Jason A. Pfister et al. PLoS One
- Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
- (2008) S. Hisahara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
- (2008) R. E. Infante et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
- (2008) E. A. Thomas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
- (2008) B.-H. Ahn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
- (2008) Rea Biacsi et al. PLoS Genetics
- Developmental expression of histone deacetylase 11 in the murine brain
- (2007) Hedi Liu et al. JOURNAL OF NEUROSCIENCE RESEARCH
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