☆ 4.6 Article

Exploiting invariant NKT cells to promote T-cell responses to cancer vaccines

ONCOIMMUNOLOGY (2013)

期刊

ONCOIMMUNOLOGY

卷 2, 期 4, 页码 -

出版社

LANDES BIOSCIENCE

DOI: 10.4161/onci.23789

关键词

NKT cell; cancer vaccine; dendritic cell; glioblastoma multiforme; glioma; -galactosylceramide

类别

Oncology Immunology

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Reagent

摘要

Invariant natural killer T (iNKT) cells have the capacity to amplify adaptive immune responses by licensing antigen-presenting cells. A simple vaccine consisting of whole tumor cells pulsed with an iNKT-cell agonist efficiently delivers antigens plus adjuvants to endogenous dendritic cells and has potential for clinical applications.

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