Cancer cell intrinsic TIM-3 induces glioblastoma progression

P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression

(2021) Eilam Yeini et al.   Nature Communications

Immune checkpoint signaling and cancer immunotherapy

(2020) Xing He et al.   CELL RESEARCH

Tim-3 Expression and MGMT Methylation Status Association With Survival in Glioblastoma

(2020) Ji Zhang et al.   Frontiers in Pharmacology

The presence of TIM‐3 positive cells in WHO grade III and IV astrocytic gliomas correlates with isocitrate dehydrogenase mutation status

(2020) Mia D. Sørensen et al.   BRAIN PATHOLOGY

Overexpression of oncostatin M receptor regulates local immune response in glioblastoma

(2019) Qing Guo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer

(2019) In-Hye Ham et al.   Molecular Cancer

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

(2019) Fei Chen et al.   NATURE CELL BIOLOGY

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Genetic and molecular epidemiology of adult diffuse glioma

(2019) Annette M. Molinaro et al.   Nature Reviews Neurology

Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p

(2019) Pengfei Wu et al.   Nature Communications

Mapping microglia states in the human brain through the integration of high-dimensional techniques

(2019) Roman Sankowski et al.   NATURE NEUROSCIENCE

Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma

(2018) Hirokazu Sadahiro et al.   CANCER RESEARCH

Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape

(2018) Max D. Wellenstein et al.   IMMUNITY

Oncolytic virotherapy in glioblastoma patients induces a tumor macrophage phenotypic shift leading to an altered glioblastoma microenvironment

(2018) Wouter B L van den Bossche et al.   NEURO-ONCOLOGY

Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis

(2018) Hualin Zhang et al.   ONCOGENE

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

(2018) Qirui Wang et al.   Nature Communications

Second-line treatments of small-cell lung cancers

(2017) Nathalie Baize et al.   Expert Review of Anticancer Therapy

Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators

(2017) Hung N. Nguyen et al.   IMMUNITY

Tim-3 and its role in regulating anti-tumor immunity

(2017) Madhumita Das et al.   IMMUNOLOGICAL REVIEWS

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives

(2017) Lidia M. Yshii et al.   Nature Reviews Neurology

Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth

(2017) Yu Shi et al.   Nature Communications

Calreticulin Release at an Early Stage of Death Modulates the Clearance by Macrophages of Apoptotic Cells

(2017) Rim Osman et al.   Frontiers in Immunology

Molecular and clinical characterization of TIM-3 in glioma through 1,024 samples

(2017) Guanzhang Li et al.   OncoImmunology

Preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma

(2017) Abhishek D. Garg et al.   OncoImmunology

Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner

(2016) Sung-Hak Kim et al.   CANCER CELL

FOXD1–ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells

(2016) Peng Cheng et al.   CANCER RESEARCH

Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

(2016) Jennifer E. Kim et al.   CLINICAL CANCER RESEARCH

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

(2016) Frank A. Schildberg et al.   IMMUNITY

GlioVis data portal for visualization and analysis of brain tumor expression datasets

(2016) Robert L. Bowman et al.   NEURO-ONCOLOGY

Bioinformatic profiling identifies an immune-related risk signature for glioblastoma

(2016) Wen Cheng et al.   NEUROLOGY

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

(2015) Sonja Kleffel et al.   CELL

A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

(2015) Yoshikane Kikushige et al.   Cell Stem Cell

Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients With Acute Alcoholic Hepatitis

(2015) Lee J.L. Markwick et al.   GASTROENTEROLOGY

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia

(2015) Han Seok Koh et al.   Nature Communications

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature

(2011) Zhenyu Qin   ATHEROSCLEROSIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways

(2011) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

De novo Induction of Genetically Engineered Brain Tumors in Mice Using Plasmid DNA

(2009) S. M. Wiesner et al.   CANCER RESEARCH

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS

Reprogramming Retinal Pigment Epithelium to Differentiate Toward Retinal Neurons withSox2

(2009) Wenxin Ma et al.   STEM CELLS

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols