Immunoglobulin Free Light Chains and GAGs Mediate Multiple Myeloma Extracellular Vesicles Uptake and Secondary NfκB Nuclear Translocation

A critical role for the NFkB pathway in multiple myeloma

(2015)   Oncotarget

Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB

(2015) Yulia N. Demchenko et al.   Oncotarget

Co-opting biology to deliver drugs

(2014) Parisa Yousefpour et al.   BIOTECHNOLOGY AND BIOENGINEERING

NF-κB pathways in hematological malignancies

(2014) Chiara Gasparini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Diagnostic and Prognostic Potential of Extracellular Vesicles in Peripheral Blood

(2014) Anne Louise Schacht Revenfeld et al.   CLINICAL THERAPEUTICS

Exosome and microvesicle mediated phene transfer in mammalian cells

(2014) Helena C. Christianson et al.   SEMINARS IN CANCER BIOLOGY

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

(2013) Camilla A. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression

(2013) Aldo M. Roccaro et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemotherapy stimulates syndecan-1 shedding: A potentially negative effect of treatment that may promote tumor relapse

(2013) Vishnu C. Ramani et al.   MATRIX BIOLOGY

C-src Enriched Serum Microvesicles Are Generated in Malignant Plasma Cell Dyscrasia

(2013) Giuseppe Di Noto et al.   PLoS One

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of Multiple Myeloma Vesicles by Label-Free Relative Quantitation

(2013) Sean W. Harshman et al.   PROTEOMICS

Differences in Immunoglobulin Light Chain Species Found in Urinary Exosomes in Light Chain Amyloidosis (AL)

(2012) Marina Ramirez-Alvarado et al.   PLoS One

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

Effects of Transport Inhibitors on the Cellular Uptake of Carboxylated Polystyrene Nanoparticles in Different Cell Lines

(2011) Tiago dos Santos et al.   PLoS One

Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia

(2010) Anatoliy I. Masyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Immunoglobulin light chains activate nuclear factor- B in renal epithelial cells through a Src-dependent mechanism

(2010) W.-Z. Ying et al.   BLOOD

Immunoglobulin Light Chains Activate Tubular Epithelial Cells through Redox Signaling

(2010) K. Basnayake et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

5-Hydroxy-2-Methyl-1,4-Naphthoquinone, a Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization

(2010) S. K. Sandur et al.   MOLECULAR CANCER RESEARCH

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Validation of PDGFR  and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib

(2008) A. M. L. Coluccia et al.   BLOOD