Simple, versatile, and chemoselective reduction of secondary amides and lactams to amines with the Tf2O–NaBH4 or Cp2ZrHCl–NaBH4 system

Concise and Enantioselective Total Synthesis of (−)-Mehranine, (−)-Methylenebismehranine, and RelatedAspidospermaAlkaloids

(2014) Marius Mewald et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Brønsted Acid Catalyzed Redox Arylation

(2014) Bo Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoselective Intermolecular α-Arylation of Amides

(2014) Bo Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tertiary amide-based Knoevenagel-type reactions: a direct, general, and chemoselective approach to enaminones

(2014) Pei-Qiang Huang et al.   CHEMICAL COMMUNICATIONS

Efficient metal-free hydrosilylation of tertiary, secondary and primary amides to amines

(2014) Enguerrand Blondiaux et al.   CHEMICAL COMMUNICATIONS

Review of Methods for the Catalytic Hydrogenation of Carboxamides

(2014) Andrew M. Smith et al.   CHEMICAL REVIEWS

Two-step Synthesis of Multi-Substituted Amines by Using anN-Methoxy Group as a Reactivity Control Element

(2014) Makoto Yoritate et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemoselective Reductive Nucleophilic Addition to Tertiary Amides, Secondary Amides, andN-Methoxyamides

(2014) Minami Nakajima et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reduction of N-Allylamides by LiAlH4: Unexpected Attack of the Double Bond with Mechanistic Studies of Product and Byproduct Formation

(2014) Birk Thiedemann et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Chemoselective Reduction of Amides (Primary, Secondary, Tertiary) to Alcohols using SmI2/Amine/H2O under Mild Conditions

(2014) Michal Szostak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleophilic addition to N-alkoxyamides

(2014) Takaaki Sato et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic Hydrogenation of Carboxylic Acid Esters, Amides, and Nitriles with Homogeneous Catalysts

(2014) Svenja Werkmeister et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A versatile two-step method for the reductive alkylation and formal [4 + 2] annulation of secondary lactams: step economical syntheses of the ant venom alkaloids (2R,5S)-2-butyl-5-propylpyrrolidine and (+)-monomorine I

(2014) Hui-Qiong Deng et al.   Organic Chemistry Frontiers

A Practical Procedure for Reduction of Primary, Secondary and Tertiary Amides to Amines

(2013) Jonathan T. Reeves et al.   ADVANCED SYNTHESIS & CATALYSIS

A Convenient and General Reduction of Amides to Amines with Low-Valent Titanium

(2013) Tongxin Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Total Synthesis of (±)-Gephyrotoxin by Amide-Selective Reductive Nucleophilic Addition

(2013) Kenji Shirokane et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Reduction of Amides to Amines by Boronic Acid Catalyzed Hydrosilylation

(2013) Yuehui Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Versatile construction of functionalized tropane ring systems based on lactam activation: enantioselective synthesis of (+)-pervilleine B

(2013) Su-Yu Huang et al.   CHEMICAL COMMUNICATIONS

General One-Pot Reductivegem-Bis-Alkylation of Tertiary Lactams/Amides: Rapid Construction of 1-Azaspirocycles and Formal Total Synthesis of (±)-Cephalotaxine

(2013) Kai-Jiong Xiao et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Direct and General Method for the Reductive Alkylation of Tertiary Lactams/Amides: Application to the Step Economical Synthesis of Alkaloid (−)-Morusimic Acid D

(2013) Kai-Jiong Xiao et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (−)-Nakadomarin A

(2013) Simone Bonazzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Transformation of Amides into α-Amino Phosphonates via a Reductive Phosphination Process

(2013) Yuzhen Gao et al.   ORGANIC LETTERS

Cesium Carbonate-Catalyzed Reduction of Amides with Hydrosilanes

(2013) Weilong Xie et al.   ORGANOMETALLICS

Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditions

(2013) B. Ravinder et al.   TETRAHEDRON LETTERS

General Direct Transformation of Secondary Amides to Ketones via Amide Activation

(2012) Kaijiong Xiao et al.   ACTA CHIMICA SINICA

Direct Transformation of Secondary Amides into Secondary Amines: Triflic Anhydride Activated Reductive Alkylation

(2012) Kai-Jiong Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Mild Benzannulation through Directed Cycloaddition Reactions

(2012) James D. Kirkham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Hydrogenation of Amides to Amines under Mild Conditions

(2012) Mario Stein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A general and selective copper-catalyzed reduction of secondary amides

(2012) Shoubhik Das et al.   CHEMICAL COMMUNICATIONS

Rapid and Efficient Access to Secondary Arylmethylamines

(2012) Nicolas Fleury-Brégeot et al.   CHEMISTRY-A EUROPEAN JOURNAL

Variation in the Site of Lithiation of 2-(2-Methylphenyl)ethanamine Derivatives

(2012) Keith Smith et al.   JOURNAL OF ORGANIC CHEMISTRY

Iridium-Catalyzed Reduction of Secondary Amides to Secondary Amines and Imines by Diethylsilane

(2012) Chen Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective synthesis of ketones and ketimines by addition of organometallic reagents to secondary amides

(2012) William S. Bechara et al.   Nature Chemistry

Direct Chemoselective Allylation of Inert Amide Carbonyls

(2012) Yukiko Oda et al.   ORGANIC LETTERS

A Scalable Synthesis of CE-157119 HCl Salt, an SRI/5-HT2A Antagonist

(2012) Yong Tao et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Large-Scale Carbonyl Reductions in the Pharmaceutical Industry

(2012) Javier Magano et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Catalytic Reductive Transformations of Carboxylic and Carbonic Acid Derivatives Using Molecular Hydrogen

(2012) Pavel A. Dub et al.   ACS Catalysis

Versatile and Direct Transformation of Secondary Amides into Ketones by Deaminative Alkylation with Organocerium Reagents

(2012) Kai-Jiong Xiao et al.   Asian Journal of Organic Chemistry

Selective Reduction of Carboxylic Acid Derivatives by Catalytic Hydrosilylation

(2011) Daniele Addis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Zinc-Catalyzed Chemoselective Reduction of Tertiary and Secondary Amides to Amines

(2011) Shoubhik Das et al.   CHEMISTRY-A EUROPEAN JOURNAL

Electrochemical Synthesis and Chemistry of Chiral 1-Cyanotetrahydroisoquinolines. An Approach to the Asymmetric Syntheses of the Alkaloid (−)-Crispine A and Its Natural (+)-Antipode

(2011) Fadila Louafi et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (±)-Maistemonine, (±)-Stemonamide, and (±)-Isomaistemonine

(2011) Zhi-Hua Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Mild NonepimerizingN-Alkylation of Amines by Alcohols without Transition Metals

(2011) Claire Guérin et al.   ORGANIC LETTERS

Cobalt-Catalyzed Coupling of Alkyl Grignard Reagent with Benzamide and 2-Phenylpyridine Derivatives through Directed C–H Bond Activation under Air

(2011) Quan Chen et al.   ORGANIC LETTERS

Microwave-Assisted Solventless Reaction of Iridium-Catalyzed Alkylation of Amines with Alcohols in the Absence of Base

(2011) Weixing Zhang et al.   ORGANIC LETTERS

Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation

(2010) Kai-Jiong Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Versatile One-Pot Reductive Alkylation of Lactams/Amides via Amide Activation: Application to the Concise Syntheses of Bioactive Alkaloids (±)-Bgugaine, (±)-Coniine, (+)-Preussin, and (−)-Cassine

(2010) Kai-Jiong Xiao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Controlled and Chemoselective Reduction of Secondary Amides

(2010) Guillaume Pelletier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zinc-Catalyzed Reduction of Amides: Unprecedented Selectivity and Functional Group Tolerance

(2010) Shoubhik Das et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Catalytic Reductions of Amides and Nitriles to Amines

(2010) Shoubhik Das et al.   TOPICS IN CATALYSIS

Pd-catalyzed ortho-arylation of phenylacetamides, benzamides, and anilides with simple arenes using sodium persulfate

(2010) Charles S. Yeung et al.   Chemical Science

Hydrosilane Reduction of Tertiary Carboxamides by Iron Carbonyl Catalysts

(2009) Yusuke Sunada et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Convenient and General Iron-Catalyzed Reduction of Amides to Amines

(2009) Shaolin Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Amine Cross-Coupling Using Iridium-Catalyzed “Borrowing Hydrogen” Methodology

(2009) Ourida Saidi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Practical Access to Amines by Platinum-Catalyzed Reduction of Carboxamides with Hydrosilanes: Synergy of Dual Si−H Groups Leads to High Efficiency and Selectivity

(2009) Shiori Hanada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A versatile approach to cis-5-substituted 4-hydroxy-2-pyrrolidinones: asymmetric synthesis of angiogenesis inhibitor streptopyrrolidine

(2009) Shao-Hua Xiang et al.   TETRAHEDRON-ASYMMETRY

Synthesis of Indoles via Domino Reaction ofN-Aryl Amides and Ethyl Diazoacetate

(2008) Sun-Liang Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of (±)-stemonamide, (±)-isostemonamide, (±)-stemonamine, and (±)-isostemonamine using a radical cascade

(2008) Tsuyoshi Taniguchi et al.   TETRAHEDRON

One-step conversion to tertiary amines: InBr3/Et3SiH-mediated reductive deoxygenation of tertiary amides

(2008) Norio Sakai et al.   TETRAHEDRON LETTERS

Highly Chemoselective Metal-Free Reduction of Tertiary Amides

(2007) Guillaume Barbe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY