Linaclotide: A new drug for the treatment of chronic constipation and irritable bowel syndrome with constipation

Mo1849 Mechanism of Action for Linaclotide Induced Abdominal Pain Relief

(2015) Joel Castro et al.   GASTROENTEROLOGY

Randomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints

(2012) E. M. M. Quigley et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Systematic review: cardiovascular safety profile of 5-HT4 agonists developed for gastrointestinal disorders

(2012) J. Tack et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis

(2012) Rebecca M. Lovell et al.   Clinical Gastroenterology and Hepatology

Guanylate cyclase-C receptor activation: unexpected biology

(2012) Stuart M Brierley   CURRENT OPINION IN PHARMACOLOGY

Prucalopride in the treatment of chronic constipation in patients from the Asia-Pacific region: a randomized, double-blind, placebo-controlled study

(2012) M. Ke et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome

(2011) P. Clavé et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Prevalence of and Risk Factors for, Chronic Idiopathic Constipation in the Community: Systematic Review and Meta-analysis

(2011) Nicole C Suares et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Current and future therapies for chronic constipation

(2011) J. Tack   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Quality of life in children and adults with constipation

(2011) Arnold Wald et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Impact of Chronic Constipation on Health-Related Quality of Life, Work Productivity, and Healthcare Resource Use: An Analysis of the National Health and Wellness Survey

(2011) Shawn X. Sun et al.   DIGESTIVE DISEASES AND SCIENCES

Diagnosis and treatment of chronic constipation - a European perspective

(2011) J. Tack et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Two Randomized Trials of Linaclotide for Chronic Constipation

(2011) Anthony J. Lembo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clarification of trial end points presented in a recent review of linaclotide

(2011) Jeffrey M Johnston et al.   Expert Review of Gastroenterology & Hepatology

Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation

(2010) J. F. JOHANSON et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Evolution of Clinical Trials for Irritable Bowel Syndrome: Issues in End Points and Study Design

(2010) Ann Marie Trentacosti et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

(2010) Robert W. Busby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation

(2010) Jeffrey M. Johnston et al.   GASTROENTEROLOGY

Efficacy of Linaclotide for Patients With Chronic Constipation

(2010) Anthony J. Lembo et al.   GASTROENTEROLOGY

Current Medical Treatments of Dyspepsia and Irritable Bowel Syndrome

(2010) Michael Camilleri et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

(2010) Alexander P. Bryant et al.   LIFE SCIENCES

5-HT4 receptor agonists: similar but not the same

(2010) J. H. De Maeyer et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases

(2010) Lincoln R. Potter   PHARMACOLOGY & THERAPEUTICS

Efficacy and Safety of Lubiprostone in Patients with Chronic Constipation

(2009) Charles F. Barish et al.   DIGESTIVE DISEASES AND SCIENCES

Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain

(2009) h. eutamene et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies

(2008) D. A. DROSSMAN et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation - a 12-week, randomized, double-blind, placebo-controlled study

(2008) E. M. M. QUIGLEY et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation

(2008) Jeffrey M Johnston et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Treatment of Chronic Constipation: Current Pharmacologic Approaches and Future Directions

(2008) Jan Tack et al.   Clinical Gastroenterology and Hepatology

Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives

(2008) J Tack et al.   GUT

A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation

(2008) Michael Camilleri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multicenter, 4-Week, Double-Blind, Randomized, Placebo-Controlled Trial of Lubiprostone, a Locally-Acting Type-2 Chloride Channel Activator, in Patients With Chronic Constipation

(2007) John F Johanson et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY