In vivotumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity

Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation

(2014) S. Zhu et al.   BLOOD

Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance

(2014) D. Gotthardt et al.   BLOOD

A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders

(2014) T. Velusamy et al.   BLOOD

NK cells gain higher IFN-γ competence during terminal differentiation

(2014) Merlin Luetke-Eversloh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Evaluation of WO2013125543, WO2013146963 and EP2634185: the first Tyk2 inhibitors from Takeda and Sareum

(2014) Peter Norman   EXPERT OPINION ON THERAPEUTIC PATENTS

Therapeutic potential of tyrosine kinase 2 in autoimmunity

(2014) Yan Liang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Role of Type I Interferon Receptor Signaling on NK Cell Development and Functions

(2014) Jean Guan et al.   PLoS One

Design of a Peptide Inhibitor of Tyrosine Kinase 2

(2014) Melissa Works et al.   PROTEIN AND PEPTIDE LETTERS

Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance

(2014) Raimund M. Vielnascher et al.   TRANSGENIC RESEARCH

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

(2014) Dorothy K Sojka et al.   eLife

Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells

(2013) R. Trotta et al.   BLOOD

IL-18-Primed Helper NK Cells Collaborate with Dendritic Cells to Promote Recruitment of Effector CD8+ T Cells to the Tumor Microenvironment

(2013) J. L. Wong et al.   CANCER RESEARCH

Lead identification of novel and selective TYK2 inhibitors

(2013) Jun Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tyk2 is a therapeutic target for psoriasis-like skin inflammation

(2013) M. Ishizaki et al.   INTERNATIONAL IMMUNOLOGY

Liver-resident NK cells confer adaptive immunity in skin-contact inflammation

(2013) Hui Peng et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-155 Tunes Both the Threshold and Extent of NK Cell Activation via Targeting of Multiple Signaling Pathways

(2013) R. P. Sullivan et al.   JOURNAL OF IMMUNOLOGY

Two Rare Disease-Associated Tyk2 Variants Are Catalytically Impaired but Signaling Competent

(2013) Z. Li et al.   JOURNAL OF IMMUNOLOGY

TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia

(2013) Takaomi Sanda et al.   Cancer Discovery

CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance

(2013) Eva Maria Putz et al.   Cell Reports

MicroRNA regulation of natural killer cells

(2013) Ryan P. Sullivan et al.   Frontiers in Immunology

Establishing the role of tyrosine kinase 2 in cancer

(2013) Caroline Übel et al.   OncoImmunology

miR-155 regulates IFN-  production in natural killer cells

(2012) R. Trotta et al.   BLOOD

Impairment of hepatic NK cell development in IFN-γ deficient mice

(2012) Xian Wu et al.   CYTOKINE

Type I IFN receptor controls activated TYK2 in the nucleus: Implications for EAE therapy

(2012) Chulbul M. Ahmed et al.   JOURNAL OF NEUROIMMUNOLOGY

A Patient with Tyrosine Kinase 2 Deficiency without Hyper-IgE Syndrome

(2012) Sara S. Kilic et al.   JOURNAL OF PEDIATRICS

TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo

(2012) Michaela Prchal-Murphy et al.   PLoS One

Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

(2012) Tatsuaki Mizutani et al.   OncoImmunology

Jak1 Has a Dominant Role over Jak3 in Signal Transduction through γc-Containing Cytokine Receptors

(2011) Claude Haan et al.   CHEMISTRY & BIOLOGY

Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity

(2011) Birgit Strobl   Frontiers in Bioscience-Landmark

The Role of Tyk2 in Regulation of Breast Cancer Growth

(2011) Qifang Zhang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Next-generation sequencing identifies the natural killer cell microRNA transcriptome

(2010) T. A. Fehniger et al.   GENOME RESEARCH

DNAM-1/CD155 Interactions Promote Cytokine and NK Cell-Mediated Suppression of Poorly Immunogenic Melanoma Metastases

(2009) C. J. Chan et al.   JOURNAL OF IMMUNOLOGY

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

(2009) E. Caldas-Lopes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of an Indispensable Role for Tyrosine Kinase 2 in CTL-Mediated Tumor Surveillance

(2008) O. Simma et al.   CANCER RESEARCH

DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors

(2008) Susan Gilfillan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells

(2007) Hisamitsu Ide et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS