Review
Biochemistry & Molecular Biology
Jibrin Danladi, Hemmen Sabir
Summary: Neonatal encephalopathy is a global burden, with the majority of cases occurring in low- and middle-income countries. The use of therapeutic hypothermia for treating neonatal encephalopathy has led to increased neonatal mortality rates. The heat shock and cold shock protein responses are crucial for survival and can modify cellular signaling and immune cell mobilization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Peng Bai, Qiuping Zhou, Pengcheng Wei, Hua Bai, Sanny K. Chan, John W. Kappler, Philippa Marrack, Lei Yin
Summary: Cytotoxic T cells targeting cancer neoantigens carrying driver mutations can induce durable tumor regression in an HLAI-dependent manner. A combinatorial strategy has been proposed to find alternative HLA alleles that can present clinically effective neoantigens, expanding the eligible patient population for immunotherapy targeting specific mutations like KRAS G12D.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hamidreza Khodajou-Masouleh, S. Shirin Shahangian, Farnoosh Attar, Reza H. Sajedi, Behnam Rasti
Summary: This review discusses the molecular and cellular basis of stress tolerance in resistant biological systems, focusing on Artemia as a biological model. It explores how protective factors such as late embryogenesis abundant proteins, small heat shock proteins, and trehalose are related to their functions in stress tolerance. The review also highlights the metabolic depressors in Artemia encysted embryos and the unique folding behaviors and mechanisms of action of LEAPs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Ecology
Emily A. O'Connor, Helena Westerdahl
Summary: The study examines the relationship between genomic and expressed MHC diversity in songbirds, revealing that fewer MHC-I alleles are expressed than the number available, suggesting optimal MHC-I diversity might be achieved through modulating gene expression. Understanding this relationship is crucial for interpreting variation in MHC diversity in an evolutionary context.
Article
Oncology
Peng Bai, Yongzheng Li, Qiuping Zhou, Jiaqi Xia, Peng-Cheng Wei, Hexiang Deng, Min Wu, Sanny K. Chan, John W. Kappler, Yu Zhou, Eric Tran, Philippa Marrack, Lei Yin
Summary: Genetic mutations lead to mutated proteins that present peptides to T cells as cancer neoantigens. Classifying neoantigen data and discovering specific rules can improve the prioritization of immunogenic neoantigens, leading to the design of more effective cancer immunotherapies.
Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Article
Multidisciplinary Sciences
Sarah J. Simpson, Damien P. Higgins, Peter Timms, Valentina S. A. Mella, Mathew S. Crowther, Cristina M. Fernandez, Clare Mcarthur, Samuel Phillips, Mark B. Krockenberger
Summary: This study investigated the effectiveness of a synthetic peptide vaccine against chlamydiosis in a heavily affected koala population over an 18-month period. The results showed that the vaccine did not effectively manage chlamydial infection and related diseases in a population with a high prevalence of the infection.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Luca D. Bertzbach, Clive A. Tregaskes, Rebecca J. Martin, Undine-Sophie Deumer, Lan Huynh, Ahmed M. Kheimar, Andele M. Conradie, Jakob Trimpert, Jim Kaufman, Benedikt B. Kaufer
Summary: The major histocompatibility complex (MHC) is crucial for appropriate immune responses against invading pathogens in chickens. VALO specific pathogen free (SPF) chickens possess MHC haplotypes that include B9, B9:02, B15, B19, and B21 at various frequencies. The study found that B15 homozygotes had the lowest tumor incidence while B21 homozygotes had the lowest number of organs with tumors. The data have immediate implications for the use of VALO SPF chickens and eggs in the life sciences.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Anthony Guihur, Bruno Fauvet, Andrija Finka, Manfredo Quadroni, Pierre Goloubinoff
Summary: In the scorching summer dawn, land plants establish molecular defenses to prepare for extreme midday temperatures, inducing heat-shock proteins for acquired thermotolerance. Despite high protein crowding, heat priming did not accumulate HSP chaperones in chloroplasts, while HSP20s accumulated in the cytosol, suggesting their role in preventing heat-labile protein aggregation.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Ahmed Barakat, Even Birkeland, Melissa D. Jorstad, Magalie El Hajj, Msafiri Marijani, Anne Doskeland, Olav Mjaavatten, Frode S. Berven, Tehmina Mustafa
Summary: This study investigated the proteomic profile of PBMCs in pulmonary tuberculosis (PTB) patients to predict treatment response. Blood samples were collected from 8 adult PTB patients in Tanzania at baseline, 2 months of treatment, and treatment completion. Proteins extracted from PBMCs were quantified and analyzed using LC-MS/MS. The results identified differentially expressed proteins involved in cellular processes, metabolic processes, binding, and catalytic activity, suggesting that proteome analysis of PBMCs can be used as a novel technique to monitor anti-tuberculosis treatment response and gain insights into PTB.
Article
Plant Sciences
Tung-Yi Lin, Wei-Jyun Hua, Hsin Yeh, Ai-Jung Tseng
Summary: The study demonstrates that FIPs LZ-8 and GMI induce changes in the proteomic profile of tumor lesions in LLC1 cell-bearing mouse, potentially regulating heat shock proteins (HSPs)-related cell viability and inhibiting cell migration and inducing apoptosis. Inhibition of HSPs may contribute to the anti-lung cancer activity of FIPs.
Article
Biochemistry & Molecular Biology
Yuying Sun, Fang Yuan, Ling Wang, Dongfa Dai, Zhijian Zhang, Fei Liang, Nan Liu, Juan Long, Xiao Zhao, Yongzhi Xi
Summary: This study generated fine-scale maps of MHC recombination and de novo mutations in Han Chinese families, revealing recombination hotspots and Han-specific breakpoints. The MHC de novo mutation rate was found to be higher than the genome-wide de novo mutation rate, and the polymorphisms generated by mutation and recombination were located within and outside linkage disequilibrium regions of the MHC, respectively. The evolution of the MHC locus was mainly controlled by positive selection.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Immunology
Georgia F. Papadaki, Omar Ani, Tyler J. Florio, Michael C. Young, Julia N. Danon, Yi Sun, Devin Dersh, Nikolaos G. Sgourakis
Summary: Major Histocompatibility Complex class I (MHC-I) molecules present self, viral or aberrant epitopic peptides to T cell receptors (TCRs) through interactions with complementarity-determining regions and MHC-I heavy chain 'framework' residues. In this study, using structural data from peptide:MHC-I and pMHC:TCR structures, the researchers identified important residues for peptide and/or TCR binding and proposed a fixed-backbone computational design approach for engineering synthetic molecules with desired properties. Experimental results showed that chimeric molecules bridging divergent HLA alleles can bind selected peptide antigens, highlighting the potential of these synthetic HLA molecules as screening probes for peptide-centric interactions with TCRs and other therapeutic modalities.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Roland Toth, Nikolett Tokodyne Szabadi, Bence Lazar, Kitti Buda, Barbara Vegi, Judit Barna, Eszter Patakine Varkonyi, Krisztina Liptoi, Bertrand Pain, Elen Gocza
Summary: Heat stress from high environmental temperatures can negatively affect animal productivity, with studies showing a significant increase in the expression levels of HSP90 and HSF4 in heat-treated female chicken gonads.
Article
Marine & Freshwater Biology
Duan March, Daniel Brown, Rachael Gray, Ian Curthoys, Christopher Wong, Damien P. Higgins
MARINE MAMMAL SCIENCE
(2016)
Article
Zoology
Shohei Komaki, Quintin Lau, Takeshi Igawa
Article
Genetics & Heredity
Quintin Lau, Takeshi Igawa, Shohei Komaki, Yoko Satta
Article
Pathology
J. T. Mackie, A. K. Gillett, C. Palmieri, T. Feng, D. P. Higgins
JOURNAL OF COMPARATIVE PATHOLOGY
(2016)
Review
Public, Environmental & Occupational Health
L. V. Wicker, P. J. Canfield, D. P. Higgins
ZOONOSES AND PUBLIC HEALTH
(2017)
Letter
Public, Environmental & Occupational Health
J. Millan, L. V. Wicker, P. J. Canfield, D. P. Higgins
ZOONOSES AND PUBLIC HEALTH
(2017)
Article
Biochemical Research Methods
Maira N. Meggiolaro, Anna Ly, Benjamin Rysnik-Steck, Carolina Silva, Joshua Zhang, Damien P. Higgins, Gary Muscatello, Jacqueline M. Norris, Mark Krockenberger, Jan Slapeta
MOLECULAR AND CELLULAR PROBES
(2017)
Article
Ecology
Shannon R. Kjeldsen, Herman W. Raadsma, Kellie A. Leigh, Jennifer R. Tobey, David Phalen, Andrew Krockenberger, William A. Ellis, Emily Hynes, Damien P. Higgins, Kyall R. Zenger
Article
Multidisciplinary Sciences
Iona E. Maher, Damien P. Higgins
Article
Pathology
Chiara Palmieri, Lyndal Hulse, Sara Pagliarani, Rebecca Larkin, Damien P. Higgins, Kenneth Beagley, Stephen Johnston
VETERINARY PATHOLOGY
(2019)
Article
Microbiology
Cristina M. Fernandez, Laura J. Schmertmann, Damien P. Higgins, Andrea Casteriano, Laszlo Irinyi, Valentina S. A. Mella, Mathew S. Crowther, Wieland Meyer, Mark B. Krockenberger
VETERINARY MICROBIOLOGY
(2019)
Article
Parasitology
Maira N. Meggiolaro, Florian Roeber, Victoria Kobylski, Damien P. Higgins, Jan Slapeta
VETERINARY PARASITOLOGY
(2019)
Article
Multidisciplinary Sciences
Iona E. Maher, Jade Patterson, Megan Curnick, Joanne Devlin, Damien P. Higgins
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Caroline Marschner, Mark B. Krockenberger, Damien P. Higgins, Christopher Mitchell, Ben D. Moore
JOURNAL OF CHEMICAL ECOLOGY
(2019)
Article
Environmental Sciences
Caroline Marschner, Damien P. Higgins, Mark B. Krockenberger
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2017)