Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Pharmacology & Pharmacy
Roberta Giordo, Anna Maria Posadino, Arduino Aleksander Mangoni, Gianfranco Pintus
Summary: An intricate interplay between genetic and environmental factors contributes to the development of type 2 diabetes (T2D) and its complications. Metformin, a derivative of biguanide, exerts pleiotropic effects through multiple epigenetic modifications, which are reported in various organs, tissues, and cellular compartments. This review discusses the emerging evidence regarding metformin-mediated epigenetic modifications, their significance, potential applications, and future research directions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Yoshitaka Kubota, Hidekazu Nagano, Kentaro Kosaka, Hideyuki Ogata, Akitoshi Nakayama, Masataka Yokoyama, Kazutaka Murata, Shinsuke Akita, Motone Kuriyama, Nobutaka Furuyama, Masayuki Kuroda, Tomoaki Tanaka, Nobuyuki Mitsukawa
Summary: Ceiling culture-derived preadipocytes (ccdPAs) and adipose-derived stem cells (ASCs) were isolated from human subcutaneous fat tissue and showed differences in adipogenic potential due to variations in methylation and histone modification levels of adipogenesis-related genes, such as PPARc, fatty acid-binding protein 4, and leptin. Genomewide epigenetic analysis revealed distinct patterns in CpG methylation and H3K4me3 modification between ccdPAs and ASCs, suggesting epigenetic mechanisms underlying adipogenic differentiation capabilities of these cell types.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Chemistry, Medicinal
Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Yuan Zhou, Jun Ren
Summary: This article discusses the pathogenesis of alcohol-related liver disease (ARLD) and alcoholic liver disease (ALD), with a focus on the role of epigenetic factors in the development of liver disorders. Through cellular and animal model studies, the alcohol-induced epigenetic modifications (AIEM) and their relationship with liver diseases are explored, and epigenetics-based therapeutic options for managing ARLD and ALD are proposed.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Oncology
Yuhao Zhao, Mao Yang, Shijia Wang, Sk Jahir Abbas, Junzhe Zhang, Yongsheng Li, Rong Shao, Yingbin Liu
Summary: This review focuses on the mechanistic insights of DNA, histone, and RNA methylation in regulating the progression of pancreatic cancer. The roles of methylation regulators in modulating gene expression associated with cell proliferation, invasion, and apoptosis are discussed. Recent clinical trials on methylation drug targeting are also explored. Understanding the novel regulatory mechanisms of methylation modification may offer alternative opportunities to improve therapeutic efficacy in combating this devastating disease.
FRONTIERS IN ONCOLOGY
(2022)
Review
Neurosciences
Lin-Hui Ma, Jing Yan, Xin-Hao Jiao, Cheng-Hua Zhou, Yu-Qing Wu
Summary: The definite mechanism of how anesthesia affects cognition in neonates remains largely unknown, but epigenetic modifications have been identified as playing a significant role. This review discusses the involvement of epigenetic mechanisms in neonatal anesthesia-induced cognitive dysfunction and analyzes the potential of targeting epigenetics for treatment.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Qian Xiang, Yongzhao Zhao, Jialiang Lin, Shuai Jiang, Weishi Li
Summary: This study systematically discusses the different epigenetic modifications and their potential functions in the process of spinal ligament aging.
AGEING RESEARCH REVIEWS
(2022)
Review
Endocrinology & Metabolism
Yu Wang, Zhao Huang, Bowen Li, Lin Liu, Canhua Huang
Summary: This article reviews the epigenetic regulation of ovarian cancer drug resistance and highlights the important role of epigenetic modifications, including upregulation of multidrug resistance proteins, remodeling of the tumor microenvironment, and deregulated immune response, in drug resistance of ovarian cancer. A better understanding of these mechanisms may improve outcomes for ovarian cancer patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rachel J. Kehrberg, Namita Bhyravbhatla, Surinder K. Batra, Sushil Kumar
Summary: Cancer-associated fibroblasts (CAFs), a significant component of the tumor microenvironment (TME), contribute to cancer progression through the secretion of extracellular matrix (ECM), growth factors, and metabolites. It is now well recognized that CAFs are a heterogenous population with ablation experiments leading to reduced tumor growth and single-cell RNA sequencing demonstrating CAF subgroups. CAFs lack genetic mutations yet substantially differ from their normal stromal precursors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Genetics & Heredity
Subramaniam Jayanthi, Michael T. McCoy, Jean Lud Cadet
Summary: Methamphetamine-use disorder is a serious condition that can lead to long-term changes in the brain and gene expression, highlighting the importance of researching the underlying mechanisms.
Article
Immunology
Rutger J. Wierda, Marieke Goedhart, Marja C. J. A. van Eggermond, Alice F. Muggen, Xanne M. Miggelbrink, Sacha B. Geutskens, Erik van Zwet, Geert W. Haasnoot, Peter J. van den Elsen
Article
Ophthalmology
Naoimh Herlihy, Mehmet Dogrusoz, T. Huibertus van Essen, J. William Harbour, Pieter A. van der Velden, Marja C. J. A. van Eggermond, Geert W. Haasnoot, Peter J. van den Elsen, Martine J. Jager
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Article
Medicine, Research & Experimental
Rutger J. Wierda, Inge M. Rietveld, Marja C. J. A. van Eggermond, Jeroen A. M. Belien, Erik W. van Zwet, Jan H. N. Lindeman, Peter J. van den Elsen
Article
Biochemistry & Molecular Biology
Anne Benard, Connie M. Janssen, Peter J. van den Elsen, Marja C. J. A. van Eggermond, Dave S. B. Hoon, Cornelis J. H. van de Velde, Peter J. K. Kuppen
Article
Biochemistry & Molecular Biology
Corry M. R. Weemaes, Maarten J. D. van Tol, Jun Wang, Monique M. van Ostaijen-ten Dam, Marja C. J. A. van Eggermond, Peter E. Thijssen, Caner Aytekin, Nicola Brunetti-Pierri, Mirjam van der Burg, E. Graham Davies, Alina Ferster, Dieter Furthner, Giorgio Gimelli, Andy Gennery, Barbara Kloeckener-Gruissem, Stephan Meyn, Cynthia Powell, Ismail Reisli, Catharina Schuetz, Ansgar Schulz, Andrea Shugar, Peter J. van den Elsen, Silvere M. van der Maarel
EUROPEAN JOURNAL OF HUMAN GENETICS
(2013)
Article
Immunology
S. Anwar Jagessar, Nicole Heijmans, Erwin L. A. Blezer, Jan Bauer, Jeroen H. Blokhuis, Jacqueline A. M. Wubben, Jan W. Drijfhout, Peter J. van den Elsen, Jon D. Laman, Bert A. 't Hart
EUROPEAN JOURNAL OF IMMUNOLOGY
(2012)
Article
Immunology
Pritesh Lalwani, Martin J. Raftery, Lidija Kobak, Andreas Rang, Thomas Giese, Markus Matthaei, Peter J. van den Elsen, Thorsten Wolff, Detlev H. Krueger, Guenther Schoenrich
EUROPEAN JOURNAL OF IMMUNOLOGY
(2013)
Article
Neurosciences
Celine Van der Putten, Hedwich F. Kuipers, Ella A. Zuiderwijk-Sick, Linda Van Straalen, Ivanela Kondova, Peter J. Van den Elsen, Jeffrey J. Bajramovic
Article
Immunology
Dalila L. Zanette, Marja C. J. A. van Eggermond, Geert Haasnoot, Peter J. van den Eisen
Article
Cell Biology
Rutger J. Wierda, Hedwich F. Kuipers, Marja C. J. A. van Eggermond, Anne Benard, Jan C. van Leeuwen, Silvia Carluccio, Sacha B. Geutskens, J. Wouter Jukema, Victor E. Marquez, Paul H. A. Quax, Peter J. van den Elsen
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2012)
Article
Immunology
Torsten B. Meissner, Yuen-Joyce Liu, Kyoung-Hee Lee, Amy Li, Amlan Biswas, Marja C. J. A. van Eggermond, Peter J. van den Elsen, Koichi S. Kobayashi
JOURNAL OF IMMUNOLOGY
(2012)
Article
Immunology
Machteld M. Tiemessen, Miranda R. M. Baert, Lianne Kok, C. J. A. van Eggermond, Peter J. van den Elsen, Ramon Arens, Frank J. T. Staal
JOURNAL OF IMMUNOLOGY
(2014)
Article
Immunology
Jack van Horssen, Shailender Singh, Susanne van der Pol, Markus Kipp, Jamie L. Lim, Laura Peferoen, Wouter Gerritsen, Evert-Jan Kooi, Maarten E. Witte, Jeroen J. G. Geurts, Helga E. de Vries, Regina Peferoen-Baert, Peter J. van den Elsen, Paul van der Valk, Sandra Amor
JOURNAL OF NEUROINFLAMMATION
(2012)
Article
Immunology
Koichi S. Kobayashi, Peter J. van den Elsen
NATURE REVIEWS IMMUNOLOGY
(2012)
Article
Clinical Neurology
Zahra Ghadimi Korka, Shohreh Noorizadeh Dehkordi, Soheil Mansour Sohani, Marzieh Yassin
Summary: The Trunk Impairment Scale (TIS) in Persian has been found to be a relevant and reliable tool for assessing trunk abnormalities in Persian-speaking people with multiple sclerosis (PWMS).
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Letter
Clinical Neurology
Daniele Caliendo, Maria Carmela Grassia, Antonio Carotenuto, Maria Petracca, Roberta Lanzillo, Vincenzo Brescia Morra, Marcello Moccia
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Maddalena Sparaco, Elisabetta Maida, Floriana Bile, Renato Vele, Luigi Lavorgna, Giuseppina Miele, Simona Bonavita
Summary: The SDQ was translated into Italian and validated for use in pwMS to detect swallowing disturbances. The 14-item SDQ demonstrated high internal consistency, good accuracy, and reliability in pwMS, making it a readily applicable tool for investigating dysphagia in MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Leticia Rodrigues Gomes, Benito Pereira Damasceno, Brunno Machado de Campos, Alfredo Damasceno
Summary: This study found that patients with multiple sclerosis (MS) have more frequent work restrictions and impairment in money management and driving abilities compared to controls. Cognitive function, physical disability, and MS lesion burden are strongly associated with work restrictions, and social cognition can influence financial capacity. Cognitive and brain reserve can help retain some of these daily occupations.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Letter
Clinical Neurology
Kaitlin E. Riegler, John Beauvais, Lindsay O. Neto, Elizabeth S. Gromisch
Summary: This study examined the differences in resilience levels among individuals with multiple sclerosis (PwMS) who had sleep disorders, sleep problems, and no sleep disorders/problems. The results showed that PwMS with sleep disorders had significantly lower resilience, with the difference being driven by the support from family and friends. These findings highlight the connection between sleep and resilience in PwMS, emphasizing the importance of social support.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
A. Maunula, S. Atula, Sm Laakso, Pj Tienari
Summary: This study aimed to investigate the frequency and risk factors of FTY rebound in a hospital district in Southern Finland. The results showed that 10.5% of patients experienced a rebound, and 28% of patients had relapses of any severity after discontinuing FTY. Younger age at diagnosis, longer exposure to FTY, lower lymphocyte count, and higher neutrophil to lymphocyte ratio after discontinuation were identified as risk factors for a rebound.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)