The role of TMPRSS6/matriptase-2 in iron regulation and anemia

Hepatocyte growth factor activator inhibitor type 2 (HAI-2) modulates hepcidin expression by inhibiting the cell surface protease matriptase-2

(2013) Eva Maurer et al.   BIOCHEMICAL JOURNAL

Iron refractory iron deficiency anemia

(2013) L. De Falco et al.   HAEMATOLOGICA

Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer

(2013) Hanna Tuhkanen et al.   INTERNATIONAL JOURNAL OF CANCER

Striking the target in iron overload disorders

(2013) Karin E. Finberg   JOURNAL OF CLINICAL INVESTIGATION

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Treating Iron Overload

(2013) Clara Camaschella   NEW ENGLAND JOURNAL OF MEDICINE

Inflammation Regulates TMPRSS6 Expression via STAT5

(2013) Delphine Meynard et al.   PLoS One

Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population

(2012) Wei Gan et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Type II Transmembrane Serine Protease, Matriptase-2: Possible Links to Cancer?

(2012) Andrew Sanders et al.   Anti-Cancer Agents in Medicinal Chemistry

Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region

(2012) Eva Maurer et al.   BIOLOGICAL CHEMISTRY

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine  -thalassemia intermedia

(2012) P. J. Schmidt et al.   BLOOD

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of  -thalassemia

(2012) A. Nai et al.   BLOOD

Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6

(2012) Pauline Lee et al.   BLOOD CELLS MOLECULES AND DISEASES

A novel mutation in the CUB sequence of matriptase-2 (TMPRSS6) is implicated in iron-resistant iron deficiency anaemia (IRIDA)

(2012) Aurélie Jaspers et al.   BRITISH JOURNAL OF HAEMATOLOGY

Two novel mutations in the tmprss6 gene associated with iron-refractory iron-deficiency anaemia (irida) and partial expression in the heterozygous form

(2012) Rosa M. Pellegrino et al.   BRITISH JOURNAL OF HAEMATOLOGY

A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum

(2012) W. Chen et al.   HAEMATOLOGICA

TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia

(2012) Peng An et al.   HUMAN MOLECULAR GENETICS

Erythropoietin stimulation decreases hepcidin expression through hematopoietic activity on bone marrow cells in mice

(2012) Yusuke Sasaki et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Effect of the A736V TMPRSS6 polymorphism on the penetrance and clinical expression of hereditary hemochromatosis

(2012) Luca Valenti et al.   JOURNAL OF HEPATOLOGY

The influence of matriptase-2 on prostate cancer in vitro: A possible role for β-catenin

(2012) SIOBHAN L. WEBB et al.   ONCOLOGY REPORTS

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

(2011) D. Meynard et al.   BLOOD

TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals

(2011) A. Nai et al.   BLOOD

Liver hemojuvelin protein levels in mice deficient in matriptase-2 (Tmprss6)

(2011) Jan Krijt et al.   BLOOD CELLS MOLECULES AND DISEASES

A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA

(2010) Sandro Altamura et al.   BIOCHEMICAL JOURNAL

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

(2010) K. E. Finberg et al.   BLOOD

Increased susceptibility to iron deficiency of Tmprss6-haploinsufficient mice

(2010) A. Nai et al.   BLOOD

Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6

(2010) A. Lenoir et al.   BLOOD

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

(2010) A.-S. Zhang et al.   BLOOD

EPO-mediated reduction in Hamp expression in vivo corrects iron deficiency anaemia in TMPRSS6 deficiency

(2010) Hongfan Peng et al.   BRITISH JOURNAL OF HAEMATOLOGY

Type II Transmembrane Serine Protease (TTSP) deregulation in cancer

(2010) Siobhan et al.   Frontiers in Bioscience-Landmark

Identification of the Matriptase Second CUB Domain as the Secondary Site for Interaction with Hepatocyte Growth Factor Activator Inhibitor Type-1

(2010) Kuniyo Inouye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors

(2010) Samira Lakhal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Transferrin therapy ameliorates disease in β-thalassemic mice

(2010) Huihui Li et al.   NATURE MEDICINE

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

(2010) Z. K. Pinnix et al.   Science Translational Medicine

A genome-wide association analysis of serum iron concentrations

(2009) T. Tanaka et al.   BLOOD

Suppression of the hepcidin-encoding geneHamppermits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

(2009) Jaroslav Truksa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of Hemochromatosis

(2009) Elena Corradini et al.   GASTROENTEROLOGY

Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis

(2009) A. J. Ramsay et al.   HAEMATOLOGICA

Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms

(2009) Andrew J. Ramsay et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

(2009) John C Chambers et al.   NATURE GENETICS

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

(2009) Beben Benyamin et al.   NATURE GENETICS

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

(2008) A. R. Folgueras et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency

(2008) F. Guillem et al.   BLOOD

The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression

(2008) Paul J. Schmidt et al.   Cell Metabolism

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron

(2008) M. A. Melis et al.   HAEMATOLOGICA

Potent Inhibition and Global Co-localization Implicate the Transmembrane Kunitz-type Serine Protease Inhibitor Hepatocyte Growth Factor Activator Inhibitor-2 in the Regulation of Epithelial Matriptase Activity

(2008) Roman Szabo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic upregulation of matriptase‐2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation

(2008) Andrew J. Sanders et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

The type II transmembrane serine protease Matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles

(2007) Andrew et al.   Frontiers in Bioscience-Landmark