Review
Biochemistry & Molecular Biology
Tara Zeitoun, Ahmed El-Sohemy
Summary: Iron plays a dual role in health and disease, with contradictory findings from observational studies. Mendelian randomization is a cost-effective method to examine the long-term role of iron in various health outcomes. Recent Mendelian randomization studies have revealed the role of iron in cardiometabolic disorders, inflammation, neurological disorders, different cancers, and other health-related outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki
Summary: It was recognized more than 50 years ago that iron deposition in the liver plays a crucial role in liver disease. Recent studies on the regulation of ferroptosis and ferritinophagy prompted investigations on the association of iron and the liver. This review discusses iron absorption and handling by the liver, the role of liver macrophages, and the significance of iron regulators in iron homeostasis. It also analyzes the involvement of iron and ferroptosis in various liver diseases and presents experimental and clinical results on interventions to reduce iron deposition.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Klaus Rieneck, Karen Koefoed Rasmussen, Erwin M. Schoof, Frederik Banch Clausen, Henrietta Holze, Thomas Bergholt, Marianne Horby Jorgensen, Vibeke Brix Christensen, Runar Almaas, Peter Luttge Jordal, Marie Locard-Paulet, Kasper Runager, Leif Kofoed Nielsen, Balthasar Clemens Schlotmann, Joachim Lutken Weischenfeldt, Lars Juhl Jensen, Morten Hanefeld Dziegiel
Summary: The prevailing concept suggests that gestational alloimmune liver disease (GALD) is caused by maternal antibodies targeting an unknown antigen on the fetal liver. This study used three different experimental approaches to identify the liver target antigen of maternal antibodies from women with GALD-diagnosed babies, but did not find the GALD target antigen. The results also did not support the hypothesis that the GALD antigen is an alloantigen.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gerard M. Healy, Stephan A. R. Kannengiesser, Osvaldo Espin-Garcia, Richard Ward, Kevin H. M. Kuo, Kartik S. Jhaveri
Summary: Inline R-2*-LIC provides robust and comparable quantification of LIC compared to FerriScan, without the need for offline post-processing.
EUROPEAN RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hanan Kamel M. Saad, Alawiyah Awang Abd Rahman, Azly Sumanty Ab Ghani, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Hamid Ali Nagi Al-Jamal
Summary: Iron homeostasis is regulated by hepcidin, which is influenced by factors such as iron stores, hypoxia, inflammation, and erythropoiesis. Beta-thalassemia patients exhibit iron deficiency, iron overload, and ineffective erythropoiesis. Recent research has identified new diagnostic markers and therapeutic targets for beta-thalassemia.
Review
Medicine, Research & Experimental
Tomas Ganz, Elizabeta Nemeth, Stefano Rivella, Paul Goldberg, Andrew R. Dibble, Michael L. McCaleb, Shuling Guo, Brett P. Monia, Terrance D. Barrett
Summary: TMPRSS6 is a serine protease that is highly expressed in the liver. Mutations in TMPRSS6 were found to be the cause of iron-refractory iron deficiency anemia (IRIDA) in humans and mice. TMPRSS6 negatively regulates the expression of hepcidin, a systemic iron-regulatory hormone. Understanding the biology and mechanism of action of TMPRSS6 has led to the development of new therapeutic approaches for erythropoiesis and iron homeostasis-related diseases.
ADVANCES IN THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Jiedong Ma, Hongqi Zhang, Yufei Chen, Xiaojin Liu, Jiamin Tian, Wei Shen
Summary: This article summarizes the role of iron overload and ferroptosis in macrophages in the development of AS from the perspective of iron metabolism, highlighting their significant contribution to AS progression.
Review
Cell Biology
Xiaomin Wang, Ye Li, Li Han, Jie Li, Cun Liu, Changgang Sun
Summary: Iron overload is a high risk factor for many diseases, while flavonoids have been found to affect iron status and may act as potential complementary therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Simon Grootendorst, Jonathan de Wilde, Birgit van Dooijeweert, Annelies van Vuren, Wouter van Solinge, Roger Schutgens, Richard van Wijk, Marije Bartels
Summary: Rare hereditary anemias (RHA) are characterized by impaired red blood cell production or decreased survival, often leading to disturbances in iron metabolism and erythropoiesis, resulting in iron overload or exacerbation of chronic anemia. Iron overload is a significant issue in both transfusion-dependent and non-transfusion-dependent patients with RHA, suggesting common defects in erythroid development linked to intrinsic iron metabolism defects. Key regulators involved in the interaction between iron and erythropoiesis are discussed in the context of RHA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Qing Li, Zhigiang Zhao, Xia Zhou, Yuting Yan, Lusi Shi, Jiafan Chen, Baohui Fu, Jingyuan Mao
Summary: This review explains the possible correlations between HFpEF and ferroptosis and provides a reliable theoretical basis for future studies on its mechanism.
Review
Nutrition & Dietetics
Marcin Delijewski, Aleksandra Barton, Beata Maksym, Natalia Pawlas
Summary: Iron is a crucial transition metal in physiological processes, but it can also be toxic due to its involvement in free radical formation. Impaired iron metabolism leads to iron deficiency, anemia, and iron overload, with different prevalences in transplant patients. Limited knowledge exists on iron metabolism in lung graft recipients and donors, complicated further by the potential impact of drugs. This overview highlights the importance of understanding iron turnover in transplant patients and assessing drug effects on iron metabolism for perioperative treatment in transplantology.
Review
Nutrition & Dietetics
William Kardasis, Ethan R. Naquin, Richa Garg, Tejas Arun, Jyotsna S. Gopianand, Eshani Karmakar, Jaya P. Gnana-Prakasam
Summary: Iron is a crucial micronutrient for athletes, but impaired iron levels can hinder athletic performance. Prolonged exercise can affect iron absorption, utilization, and storage, increasing the risk of iron deficiency. On the other hand, iron overload may initially enhance performance but can have detrimental health consequences in the long term. Proper management of iron intake is crucial for improving athletic performance and overall well-being.
Article
Biochemistry & Molecular Biology
Yemin Zhang, Lu Li, Xinyu Yang, Changhua Wang
Summary: Iron overload is associated with insulin resistance and iron overload cardiomyopathy. The study found that iron overload has an impact on brown adipose tissue (BAT) and contributes to the onset of cardiomyopathy. RNA-Seq analysis and exosome coculture technology were used to reveal this process and provide new therapeutic strategies for the treatment of cardiomyopathy.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Peter Lymberopoulos, Sameer Prakash, Anjiya Shaikh, Anshul Bhatnagar, Anthony K. Allam, Karthik Goli, John A. Goss, Fasiha Kanwal, Abbas Rana, Kris Kowdley, Prasun Jalal, George Cholankeril
Summary: The study evaluates the waitlist and post-LT survival of patients with hereditary hemochromatosis (HH), finding that the short- and long-term survival rates of HH are comparable to other liver transplant recipients. Predictors for long-term survival include the presence of portal vein thrombosis, obesity measurements greater than Class II, and Karnofsky performance status at the time of transplantation. The leading cause of post-LT death is malignancy.
LIVER TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Toni Valkovic, Marija Stanic Damic
Summary: Iron plays an important role in the survival and reproduction of fungal pathogens, and there is evidence linking invasive fungal infections to iron or iron overload. Understanding the association between iron and iron overload with susceptibility to invasive fungal infections is crucial, especially for patients with hematological malignancies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Hematology
Matthew M. Heeney, Dongjing Guo, Luigia De Falco, Dean R. Campagna, Gordana Olbina, Paige P. -C. Kao, Klaus Schmitz-Abe, Fedik Rahimov, Patrick Gutschow, Keith Westerman, Vaughn Ostland, Tracy Jackson, Robert E. Klaassen, Kyriacos Markianos, Karin E. Finberg, Achille Iolascon, Mark Westerman, Wendy B. London, Mark D. Fleming
Editorial Material
Oncology
Tyler Stewart, Karin Finberg, Zenta Walther, Jeffrey L. Sklar, Navid Hafez, Joseph P. Eder, Karen Anderson, Frederick Wilson, Sarah B. Goldberg
Letter
Hematology
David B. Stagg, Rebecca L. Whittlesey, Xiuqi Li, Larisa Lozovatsky, Sara Gardenghi, Stefano Rivella, Karin E. Finberg
Article
Hematology
Juliana Xavier-Ferrucio, Vanessa Scanlon, Xiuqi Li, Ping-Xia Zhang, Larisa Lozovatsky, Nadia Ayala-Lopez, Toma Tebaldi, Stephanie Halene, Chang Cao, Mark D. Fleming, Karin E. Finberg, Diane S. Krause
Editorial Material
Hematology
Karin E. Finberg
Article
Anatomy & Morphology
Danielle L. V. Maracaja, Vidya Puthenpura, Salley G. Pels, Dennis P. O'Malley, Jeffrey L. Sklar, Karin E. Finberg, Mina L. Xu
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2020)
Article
Oncology
Keith T. Flaherty, Robert Gray, Alice Chen, Shuli Li, David Patton, Stanley R. Hamilton, Paul M. Williams, Edith P. Mitchell, A. John Iafrate, Jeffrey Sklar, Lyndsay N. Harris, Lisa M. McShane, Larry Rubinstein, David J. Sims, Mark Routbort, Brent Coffey, Tony Fu, James A. Zwiebel, Richard F. Little, Donna Marinucci, Robert Catalano, Rick Magnan, Warren Kibbe, Carol Weil, James Tricoli, Brian Alexander, Shaji Kumar, Gary K. Schwartz, Funda Meric-Bernstam, Chih-Jian Lih, Worta McCaskill-Stevens, Paolo Caimi, Naoko Takebe, Vivekananda Datta, Carlos L. Arteaga, Jeffrey S. Abrams, Robert Comis, Peter J. O'Dwyer, Barbara A. Conley
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Article
Endocrinology & Metabolism
Quiana McKnight, Sarah Jenkins, Xiuqi Li, Tracy Nelson, Arnaud Marlier, Lloyd G. Cantley, Karin E. Finberg, Jackie A. Fretz
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Hematology
Xiuqi Li, Larisa Lozovatsky, Abitha Sukumaran, Luis Gonzalez, Anisha Jain, Dong Liu, Nadia Ayala-Lopez, Karin E. Finberg
Article
Oncology
Keith T. Flaherty, Robert J. Gray, Alice P. Chen, Shuli Li, Lisa M. McShane, David Patton, Stanley R. Hamilton, P. Mickey Williams, A. John Iafrate, Jeffrey Sklar, Edith P. Mitchell, Lyndsay N. Harris, Naoko Takebe, David J. Sims, Brent Coffey, Tony Fu, Mark Routbort, James A. Zwiebel, Larry V. Rubinstein, Richard F. Little, Carlos L. Arteaga, Robert Comis, Jeffrey S. Abrams, Peter J. O'Dwyer, Barbara A. Conley
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Letter
Hematology
Jihad Womack, Abitha Sukumaran, Xiuqi Li, Larisa Lozovatsky, Patrick G. Gallagher, Jerome E. Seid, Karin E. Finberg
BLOOD CELLS MOLECULES AND DISEASES
(2021)
Editorial Material
Hematology
Karin E. Finberg
Review
Obstetrics & Gynecology
Lina Irshaid, Mitchell Clark, Oluwole Fadare, Karin E. Finberg, Vinita Parkash
Summary: Patients with germline TP53 mutations are at a higher risk of developing multiple early-onset malignancies. Li-Fraumeni syndrome is a rare autosomal dominant disorder associated with a variety of cancers, including breast carcinoma, adrenal cortical tumors, sarcomas, leukemias, and tumors of the brain and spinal cord. Gynecologic malignancies, particularly uterine carcinomas, are rarely reported in individuals with TP53 mutations. This article presents a case of an 18-year-old patient with endometrioid endometrial carcinoma and a germline TP53 mutation. The study discusses the biological aspects of the TP53 gene and p53 protein, with a focus on the R273H mutation. It also reviews the existing literature on endometrial carcinoma in patients with TP53 mutations.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2022)
Letter
Pathology
Hongjie Li, Xuchen Zhang, Karin E. Finberg, Zenta Walther, Dhanpat Jain, Joanna Gibson
PATHOLOGY INTERNATIONAL
(2022)
Editorial Material
Hematology
Karin E. Finberg
Summary: In this study, Das et al demonstrate that intestinal deletion of NCOA4, a mediator of ferritin degradation, attenuates systemic iron loading in a mouse model of hemochromatosis.
